(Q57006604)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25736574%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

title

Biology-oriented synthesis of a withanolide-inspired compound collection reveals novel modulators of hedgehog signaling (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25736574%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25736574%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Carsten Strohmann

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25736574%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Kamal Kumar

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25736574%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Herbert Waldmann

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25736574%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

author name string

Jakub Švenda

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25736574%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Michael Sheremet

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25736574%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Lea Kremer

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25736574%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Lukáš Maier

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25736574%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

Slava Ziegler

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25736574%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

language of work or name

English

0 references

publication date

3 March 2015

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25736574%20AND%20SRC:MED&resulttype=core&format=json

Angewandte Chemie International Edition

2 March 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25736574%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

volume

54

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25736574%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

issue

19

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25736574%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

page(s)

5596-5602

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25736574%20AND%20SRC:MED&resulttype=core&format=json

Natural products as sources of new drugs over the last 25 years

2 March 2020

cites work

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Natural product scaffolds as leads to drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Natural products as chemical probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Natural products to drugs: natural product-derived compounds in clinical trials

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Advances in solution- and solid-phase synthesis toward the generation of natural product-like libraries

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Biology-oriented synthesis: harnessing the power of evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Biology-oriented synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Bioactivity-guided navigation of chemical space

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Synthesis of natural product inspired compound collections

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Charting, navigating, and populating natural product chemical space for drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Discovery of protein phosphatase inhibitor classes by biology-oriented synthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Bioactivity-guided mapping and navigation of chemical space.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Interactive exploration of chemical space with Scaffold Hunter

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

A Scaffold-Tree-Merging Strategy for Prospective Bioactivity Annotation of γ-Pyrones

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Biology-oriented synthesis of a natural-product inspired oxepane collection yields a small-molecule activator of the Wnt-pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Natural withanolides: an overview

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Withaferin a strongly elicits IkappaB kinase beta hyperphosphorylation concomitant with potent inhibition of its kinase activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Steroids and flavonoids from Physalis alkekengi var. franchetii and their inhibitory effects on nitric oxide production

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Neuritic regeneration and synaptic reconstruction induced by withanolide A

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Withanoside IV and its active metabolite, sominone, attenuate Abeta(25-35)-induced neurodegeneration.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Axon- or dendrite-predominant outgrowth induced by constituents from Ashwagandha.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Withanolide derivatives from the roots of Withania somnifera and their neurite outgrowth activities.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Novel withanolides target medullary thyroid cancer through inhibition of both RET phosphorylation and the mammalian target of rapamycin pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

A withanolide coagulin-L inhibits adipogenesis modulating Wnt/β-catenin pathway and cell cycle in mitotic clonal expansion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Synthesis of sominone and its derivatives based on an RCM strategy: discovery of a novel anti-Alzheimer's disease medicine candidate "denosomin".

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Highly efficient ruthenium catalysts for the formation of tetrasubstituted olefins via ring-closing metathesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Synthesis of the A,B-ring-truncated OSW saponin analogs and their antitumor activities

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Pyridine-derived triflating reagents: An improved preparation of vinyl triflates from metallo enolates

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Induction of osteogenic differentiation by hedgehog proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Pathways and consequences: Hedgehog signaling in human disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Hedgehog pathway inhibition and the race against tumor evolution

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Molecular pathways: the hedgehog signaling pathway in cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Shifting paradigms in Hedgehog signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

A novel synthetic smoothened antagonist transiently inhibits pancreatic adenocarcinoma xenografts in a mouse model

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Macrocyclic Hedgehog Pathway Inhibitors: Optimization of Cellular Activity and Mode of Action Studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Synthesis and biological evaluation of SANT-2 and analogues as inhibitors of the hedgehog signaling pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Potent small molecule Hedgehog agonists induce VEGF expression in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Teratogen-mediated inhibition of target tissue response to Shh signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FANIE.201500112

21 January 2018

Identifiers

DOI

10.1002/ANIE.201500112

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25736574%20AND%20SRC:MED&resulttype=core&format=json

2 March 2020

1 reference