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Recent advances in the generation of chemical diversity libraries
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instance of
scholarly article
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title
Recent advances in the generation of chemical diversity libraries
(English)
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main subject
drug discovery
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author name string
Manoj C. Desai
series ordinal
1
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Ronald N. Zuckermann
series ordinal
2
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Walter H. Moos
series ordinal
3
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publication date
October 1994
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published in
Drug Development Research
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volume
33
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page(s)
174-188
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issue
2
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cites work
Use of polystyrene-1% divinylbenzene and Kel-F-g-styrene for the simultaneous synthesis of peptides
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Encoded combinatorial chemistry
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Biodiversity as a source of innovation in biotechnology
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The combinatorial synthesis and chemical and biological evaluation of a 1,4-benzodiazepine library
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An unnatural biopolymer
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Resin-bound synthetic peptides: use as antigens and immunogens
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Use of affinity capillary electrophoresis to measure binding constants of ligands to proteins
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Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist
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A strategy for the solid-phase synthesis of oligosaccharides
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"Diversomers": an approach to nonpeptide, nonoligomeric chemical diversity
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Light-directed, spatially addressable parallel chemical synthesis
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Spot-synthesis: an easy technique for the positionally addressable, parallel chemical synthesis on a membrane support
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Applications of combinatorial technologies to drug discovery. 1. Background and peptide combinatorial libraries
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Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid
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Small peptides induce antibodies with a sequence and structural requirement for binding antigen comparable to antibodies raised against the native protein
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Applications of combinatorial technologies to drug discovery. 2. Combinatorial organic synthesis, library screening strategies, and future directions
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General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids
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Simplified procedure for carrying out simultaneous multiple hydrogen fluoride cleavages of protected peptide resins
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Generation and use of synthetic peptide combinatorial libraries for basic research and drug discovery
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Inhibition of HIV replication in acute and chronic infections in vitro by a Tat antagonist
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A new type of synthetic peptide library for identifying ligand-binding activity
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Multiple release of equimolar amounts of peptides from a polymeric carrier using orthogonal linkage-cleavage chemistry
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Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide
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Generation and screening of an oligonucleotide-encoded synthetic peptide library
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Complex synthetic chemical libraries indexed with molecular tags
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The generation of molecular diversity
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Discovery of biologically active peptides in random libraries: solution-phase testing after staged orthogonal release from resin beads
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Peptoids: a modular approach to drug discovery.
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A Potent Nonpeptide Antagonist of the Substance P (NK 1 ) Receptor
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Synthesis of peptide analogues using the multipin peptide synthesis method
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Efficient method for the preparation of peptoids [oligo(N-substituted glycines)] by submonomer solid-phase synthesis
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Identification of highest-affinity ligands by affinity selection from equimolar peptide mixtures generated by robotic synthesis
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Discovery of nanomolar ligands for 7-transmembrane G-protein-coupled receptors from a diverse N-(substituted)glycine peptoid library
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Identifiers
DOI
10.1002/DDR.430330214
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