(Q57153298)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30242219%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

title

Positive cardiac inotrope omecamtiv mecarbil activates muscle despite suppressing the myosin working stroke (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30242219%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30242219%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

Michael J. Greenberg

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30242219%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

author name string

Bipasha Barua

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30242219%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

Donald A Winkelmann

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30242219%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

Yale E Goldman

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30242219%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

E Michael Ostap

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30242219%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

language of work or name

English

0 references

publication date

21 September 2018

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30242219%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

published in

Nature Communications

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30242219%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

volume

9

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30242219%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

issue

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30242219%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

page(s)

3838

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30242219%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

23 April 2020

copyright license

start time

21 September 2018

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

exact match

https://scigraph.springernature.com/pub.10.1038/s41467-018-06193-2

0 references

cites work

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Allosteric modulation of cardiac myosin dynamics by omecamtiv mecarbil.

2 November 2018

1 reference

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Omecamtiv mercabil and blebbistatin modulate cardiac contractility by perturbing the regulatory state of the myosin filament.

2 November 2018

1 reference

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Frequency-dependent effects of omecamtiv mecarbil on cell shortening of isolated canine ventricular cardiomyocytes.

2 November 2018

1 reference

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Omecamtiv Mecarbil Abolishes Length-Mediated Increase in Guinea Pig Cardiac Myofiber Ca2+ Sensitivity

2 November 2018

1 reference

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Mechanistic and structural basis for activation of cardiac myosin force production by omecamtiv mecarbil

2 November 2018

1 reference

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The molecular basis of thin filament activation: from single molecule to muscle

2 November 2018

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2 November 2018

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Omecamtiv Mecarbil Enhances the Duty Ratio of Human β-Cardiac Myosin Resulting in Increased Calcium Sensitivity and Slowed Force Development in Cardiac Muscle

2 November 2018

1 reference

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Chronic Oral Study of Myosin Activation to Increase Contractility in Heart Failure (COSMIC-HF): a phase 2, pharmacokinetic, randomised, placebo-controlled trial

2 November 2018

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Measuring the Kinetic and Mechanical Properties of Non-processive Myosins Using Optical Tweezers.

2 November 2018

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2 November 2018

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Structural basis for drug-induced allosteric changes to human β-cardiac myosin motor activity

2 November 2018

1 reference

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Harmonic force spectroscopy measures load-dependent kinetics of individual human β-cardiac myosin molecules

2 November 2018

1 reference

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The novel cardiac myosin activator omecamtiv mecarbil increases the calcium sensitivity of force production in isolated cardiomyocytes and skeletal muscle fibres of the rat

2 November 2018

1 reference

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Molecular effects of the myosin activator omecamtiv mecarbil on contractile properties of skinned myocardium lacking cardiac myosin binding protein-C

2 November 2018

1 reference

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Population pharmacokinetic-pharmacodynamic modeling of omecamtiv mecarbil, a cardiac myosin activator, in healthy volunteers and patients with stable heart failure

2 November 2018

1 reference

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Ensemble force changes that result from human cardiac myosin mutations and a small-molecule effector

2 November 2018

1 reference

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Omecamtiv Mecarbil modulates the kinetic and motile properties of porcine β-cardiac myosin

2 November 2018

1 reference

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Inherent force-dependent properties of β-cardiac myosin contribute to the force-velocity relationship of cardiac muscle.

2 November 2018

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Muscle activation described with a differential equation model for large ensembles of locally coupled molecular motors

2 November 2018

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2 November 2018

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Myosin IC generates power over a range of loads via a new tension-sensing mechanism.

2 November 2018

1 reference

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The effects of the cardiac myosin activator, omecamtiv mecarbil, on cardiac function in systolic heart failure: a double-blind, placebo-controlled, crossover, dose-ranging phase 2 trial.

2 November 2018

1 reference

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Dose-dependent augmentation of cardiac systolic function with the selective cardiac myosin activator, omecamtiv mecarbil: a first-in-man study

2 November 2018

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Cardiac myosin activation: a potential therapeutic approach for systolic heart failure

2 November 2018

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Nonlinear Elasticity and an 8-nm Working Stroke of Single Myosin Molecules in Myofilaments

2 November 2018

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Kinetic and equilibrium analysis of the myosin ATPase

2 November 2018

1 reference

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2 November 2018

1 reference

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Single-molecule measurement of the stiffness of the rigor myosin head

2 November 2018

1 reference

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Reconciling the working strokes of a single head of skeletal muscle myosin estimated from laser-trap experiments and crystal structures

2 November 2018

1 reference

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2 November 2018

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2 November 2018

1 reference

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The motor protein myosin-I produces its working stroke in two steps

2 November 2018

1 reference

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Detection of single-molecule interactions using correlated thermal diffusion

2 November 2018

1 reference

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Regulation of the interaction between actin and myosin subfragment 1: evidence for three states of the thin filament

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6155018

Single myosin molecule mechanics: piconewton forces and nanometre steps

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6155018

The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6155018

Models for the Specific Adhesion of Cells to Cells

2 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=6155018

Force and number of myosin motors during muscle shortening and the coupling with the release of the ATP hydrolysis products

2 November 2018

1 reference

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7 January 2021

Ultrafast force-clamp spectroscopy of single molecules reveals load dependence of myosin working stroke

1 reference

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7 January 2021

Electro-optic deflectors deliver advantages over acousto-optical deflectors in a high resolution, ultra-fast force-clamp optical trap

1 reference

https://api.crossref.org/works/10.1038%2FS41467-018-06193-2

7 January 2021

7 Preparation of myosin and its subfragments from rabbit skeletal muscle

1 reference

https://api.crossref.org/works/10.1038%2FS41467-018-06193-2

7 January 2021

Exact stochastic simulation of coupled chemical reactions

1 reference

https://api.crossref.org/works/10.1038%2FS41467-018-06193-2

7 January 2021

The relationship between sulfhydryl groups and the activation of myosin adenosinetriphosphatase

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/30242219

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1038/S41467-018-06193-2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30242219%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30242219%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

PubMed publication ID

30242219

1 reference