(Q57184107)

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Loss of angiotensin-converting enzyme 2 enhances TGF-β/Smad-mediated renal fibrosis and NF-κB-driven renal inflammation in a mouse model of obstructive nephropathy

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scholarly article

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22330342%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Loss of angiotensin-converting enzyme 2 enhances TGF-β/Smad-mediated renal fibrosis and NF-κB-driven renal inflammation in a mouse model of obstructive nephropathy (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22330342%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

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obstructive nephropathy

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

1 reference

based on heuristic

inferred from title

3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22330342%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Josef Penninger

4

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22330342%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

5

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22330342%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

author name string

Zhen Liu

1

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22330342%20AND%20SRC:MED&resulttype=core&format=json

22 January 2020

Xiao Ru Huang

2

1 reference

Europe PubMed Central

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22 January 2020

publication date

13 February 2012

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Europe PubMed Central

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22 January 2020

Laboratory Investigation

1 reference

Europe PubMed Central

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22 January 2020

92

1 reference

Europe PubMed Central

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22 January 2020

5

1 reference

Europe PubMed Central

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22 January 2020

650-661

1 reference

Europe PubMed Central

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22 January 2020

https://scigraph.springernature.com/pub.10.1038/labinvest.2012.2

0 references

ACE2: more of Ang-(1-7) or less Ang II?

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

Angiotensin II up-regulates angiotensin I-converting enzyme (ACE), but down-regulates ACE2 via the AT1-ERK/p38 MAP kinase pathway.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

Angiotensin-converting enzyme II in the heart and the kidney

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

Angiotensin-converting enzyme 2 is a key modulator of the renin-angiotensin system in cardiovascular and renal disease

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

ACE2 inhibition worsens glomerular injury in association with increased ACE expression in streptozotocin-induced diabetic mice.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

Glomerular localization and expression of Angiotensin-converting enzyme 2 and Angiotensin-converting enzyme: implications for albuminuria in diabetes.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

Loss of angiotensin-converting enzyme-2 leads to the late development of angiotensin II-dependent glomerulosclerosis

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

Loss of angiotensin-converting enzyme-2 (Ace2) accelerates diabetic kidney injury

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

Prevention of angiotensin II-mediated renal oxidative stress, inflammation, and fibrosis by angiotensin-converting enzyme 2.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

Human recombinant ACE2 reduces the progression of diabetic nephropathy

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

Angiotensin-converting enzyme 2 is an essential regulator of heart function

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

Disruption of the Smad7 gene promotes renal fibrosis and inflammation in unilateral ureteral obstruction (UUO) in mice.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

The protective role of Smad7 in diabetic kidney disease: mechanism and therapeutic potential

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

Angiotensin II activates the Smad pathway in vascular smooth muscle cells by a transforming growth factor-beta-independent mechanism

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

Essential role of Smad3 in angiotensin II-induced vascular fibrosis

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

Angiotensin II induces connective tissue growth factor and collagen I expression via transforming growth factor-beta-dependent and -independent Smad pathways: the role of Smad3

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

Developmental expression of ACE2 in the SHR kidney: a role in hypertension?

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

Effect of ACE2 and angiotensin-(1-7) in a mouse model of early chronic kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

Renal ACE2 expression and activity is unaltered during established hypertension in adult SHRSP and TGR(mREN2)27.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

ACE and ACE2 activity in diabetic mice.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

Increased ACE 2 and decreased ACE protein in renal tubules from diabetic mice: a renoprotective combination?

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

Expression of ACE and ACE2 in individuals with diabetic kidney disease and healthy controls

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

Decreased glomerular and tubular expression of ACE2 in patients with type 2 diabetes and kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

Characterization of renal angiotensin-converting enzyme 2 in diabetic nephropathy.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

Loss of ACE2 accelerates time-dependent glomerular and tubulointerstitial damage in streptozotocin-induced diabetic mice

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

New insights and perspectives on intrarenal renin-angiotensin system: focus on intracrine/intracellular angiotensin II

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

Intratubular renin-angiotensin system in hypertension

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

Renin-angiotensin-aldosterone system and progression of renal disease

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

Novel roles of intracrine angiotensin II and signalling mechanisms in kidney cells

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

Hypoxia and inflammation

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

Smad7 as a therapeutic agent for chronic kidney diseases.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

Blockade of NFkappaB activation and renal inflammation by ultrasound-mediated gene transfer of Smad7 in rat remnant kidney.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

Signaling mechanism of TGF-beta1 in prevention of renal inflammation: role of Smad7.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

Inhibition of renal fibrosis by gene transfer of inducible Smad7 using ultrasound-microbubble system in rat UUO model

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

Ultrasound-microbubble-mediated gene transfer of inducible Smad7 blocks transforming growth factor-beta signaling and fibrosis in rat remnant kidney.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

Smad7 gene therapy ameliorates an autoimmune crescentic glomerulonephritis in mice.

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

21 January 2018

A novel, simple, reliable, and sensitive method for multiple immunoenzyme staining: use of microwave oven heating to block antibody crossreactivity and retrieve antigens

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

7 January 2021

based on heuristic

inferred from DOI database lookup

Renal ACE2 expression in human kidney disease

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

7 January 2021

based on heuristic

inferred from DOI database lookup

Increased ACE and decreased ACE2 expression in kidneys from patients with IgA nephropathy

1 reference

https://api.crossref.org/works/10.1038%2FLABINVEST.2012.2

7 January 2021

based on heuristic

inferred from DOI database lookup

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