(Q57369771)

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CD95/phosphorylated ezrin association underlies HIV-1 GP120/IL-2-induced susceptibility to CD95(APO-1/Fas)-mediated apoptosis of human resting CD4+T lymphocytes

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17 November 2019

CD95/phosphorylated ezrin association underlies HIV-1 GP120/IL-2-induced susceptibility to CD95(APO-1/Fas)-mediated apoptosis of human resting CD4(+)T lymphocytes (English)

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17 November 2019

phosphorylation

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17 November 2019

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17 November 2019

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17 November 2019

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Luciani F

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17 November 2019

Matarrese P

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17 November 2019

Giammarioli AM

3

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17 November 2019

Lozupone F

5

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17 November 2019

Federici C

6

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17 November 2019

Iessi E

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17 November 2019

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1 May 2004

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17 November 2019

Cell Death & Differentiation

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17 November 2019

11

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17 November 2019

5

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17 November 2019

574-582

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17 November 2019

Fas and FasL in the homeostatic regulation of immune responses

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Potential involvement of Fas and its ligand in the pathogenesis of Hashimoto's thyroiditis

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Apoptosis by death factor

1 reference

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Mechanisms of CD95 (APO-1/Fas)-mediated apoptosis

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Exploiting the apoptotic process for management of HIV: are we there yet?

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Apoptosis in AIDS.

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Apoptosis occurs predominantly in bystander cells and not in productively infected cells of HIV- and SIV-infected lymph nodes

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Cell dysfunction and depletion in AIDS: the programmed cell death hypothesis

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Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals.

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T helper type 1/T helper type 2 cytokines and T cell death: preventive effect of interleukin 12 on activation-induced and CD95 (FAS/APO-1)-mediated apoptosis of CD4+ T cells from human immunodeficiency virus-infected persons

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Chemokine-receptor activation by env determines the mechanism of death in HIV-infected and uninfected T lymphocytes.

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Activation interferes with the APO-1 pathway in mature human T cells.

1 reference

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Role of the cytoskeleton in cell-to-cell transmission of human immunodeficiency virus

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Differential susceptibility to monomeric HIV gp120-mediated apoptosis in antigen-activated CD4+ T cell populations

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Actin-dependent receptor colocalization required for human immunodeficiency virus entry into host cells.

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7 January 2021

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Human intestinal lamina propria lymphocytes are naturally permissive to HIV-1 infection.

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Primary HIV-1 infection of human CD4+ T cells passaged into SCID mice leads to selection of chronically infected cells through a massive fas-mediated autocrine suicide of uninfected cells

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The mucosal immune system: primary target for HIV infection and AIDS.

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Importance of the state of activation and/or differentiation of CD4+ T cells in AIDS pathogenesis

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Moesin interacts with the cytoplasmic region of intercellular adhesion molecule-3 and is redistributed to the uropod of T lymphocytes during cell polarization

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Leukocyte polarization in cell migration and immune interactions

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The biological relevance of polykaryons in the immune response

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Segregation of leading-edge and uropod components into specific lipid rafts during T cell polarization

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Leukocyte uropod formation and membrane/cytoskeleton linkage in immune interactions

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Ezrin oligomers are major cytoskeletal components of placental microvilli: a proposal for their involvement in cortical morphogenesis.

1 reference

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Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2

1 reference

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Regulation of cortical structure by the ezrin-radixin-moesin protein family

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Cortical actin organization: lessons from ERM (ezrin/radixin/moesin) proteins

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ERM proteins: head-to-tail regulation of actin-plasma membrane interaction

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Morphogenic effects of ezrin require a phosphorylation-induced transition from oligomers to monomers at the plasma membrane

1 reference

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7 January 2021

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Ligation of CD4 surface antigen induces rapid tyrosine phosphorylation of the cytoskeletal protein ezrin

1 reference

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7 January 2021

based on heuristic

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Ezrin is a substrate for Lck in T cells

1 reference

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Binding of HIV-1 to its receptor induces tyrosine phosphorylation of several CD4-associated proteins, including the phosphatidylinositol 3-kinase

1 reference

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Tyrosine phosphorylation induced by C4 peptide constructs from HIV Gp120.

1 reference

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Human immunodeficiency virus gp120 and derived peptides activate protein tyrosine kinase p56Ick in human CD4 T lymphocytes

1 reference

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The membrane-microfilament linker ezrin is involved in the formation of the immunological synapse and in T cell activation

1 reference

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CD95 (APO-1/Fas) linkage to the actin cytoskeleton through ezrin in human T lymphocytes: a novel regulatory mechanism of the CD95 apoptotic pathway

1 reference

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Molecular ordering of the initial signaling events of CD95.

1 reference

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CD4 regulates susceptibility to Fas ligand- and tumor necrosis factor-mediated apoptosis

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The Fas signaling pathway: more than a paradigm

1 reference

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How does HIV cause depletion of CD4 lymphocytes? A mechanism involving virus signaling through its cellular receptors

1 reference

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based on heuristic

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Biochemical mechanisms of HIV induced T cell apoptosis

1 reference

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Rapid phosphorylation and reorganization of ezrin and spectrin accompany morphological changes induced in A-431 cells by epidermal growth factor

1 reference

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Ezrin is an effector of hepatocyte growth factor-mediated migration and morphogenesis in epithelial cells

1 reference

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Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway

1 reference

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Activation of the PKB/AKT pathway by ICAM-2.

1 reference

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Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120.

1 reference

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based on heuristic

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Crosslinking CD4 by human immunodeficiency virus gp120 primes T cells for activation-induced apoptosis

1 reference

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7 January 2021

based on heuristic

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CD4 T cell depletion is linked directly to immune activation in the pathogenesis of HIV-1 and HIV-2 but only indirectly to the viral load.

1 reference

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inferred from DOI database lookup

Identifiers

10.1038/SJ.CDD.4401374

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:14739941%20AND%20SRC:MED&resulttype=core&format=json

17 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

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17 November 2019

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