(Q57372579)

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Membrane-permeable Calmodulin Inhibitors (e.g.W-7/W-13) Bind to Membranes, Changing the Electrostatic Surface Potential

scientific article published in Journal of Biological Chemistry

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scholarly article

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24 December 2019

Membrane-permeable calmodulin inhibitors (e.g. W-7/W-13) bind to membranes, changing the electrostatic surface potential: dual effect of W-13 on epidermal growth factor receptor activation (English)

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24 December 2019

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24 December 2019

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24 December 2019

Antonio Villalobo

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24 December 2019

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Parijat Sengupta

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24 December 2019

María José Ruano

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24 December 2019

Urszula Golebiewska

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24 December 2019

Irina Zaitseva

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24 December 2019

Stuart McLaughlin

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16 January 2007

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24 December 2019

Journal of Biological Chemistry

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24 December 2019

282

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24 December 2019

8474-8486

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24 December 2019

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24 December 2019

Calcium signaling

1 reference

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21 January 2018

Calcium signalling: dynamics, homeostasis and remodelling

1 reference

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21 January 2018

Calmodulin: a prototypical calcium sensor

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21 January 2018

Calmodulin in action: diversity in target recognition and activation mechanisms.

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Novel aspects of calmodulin target recognition and activation

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21 January 2018

Calmodulin's flexibility allows for promiscuity in its interactions with target proteins and peptides

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Plasma membrane phosphoinositide organization by protein electrostatics

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Receptor activation alters inner surface potential during phagocytosis

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21 January 2018

PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane

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21 January 2018

Active and inactive conformations of the epidermal growth factor receptor

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21 January 2018

Rapid vesicular translocation and insertion of TRP channels

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Epidermal Growth Factor Activates Store-operated Ca2+ Channels through an Inositol 1,4,5-Trisphosphate-independent Pathway in Human Glomerular Mesangial Cells

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21 January 2018

Single-molecule analysis of epidermal growth factor signaling that leads to ultrasensitive calcium response

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The functional consequences of mis-sense mutations affecting an intra-molecular salt bridge in arylsulphatase A.

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21 January 2018

The human epidermal growth factor receptor contains a juxtamembrane calmodulin-binding site.

1 reference

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21 January 2018

Endogenous calmodulin interacts with the epidermal growth factor receptor in living cells

1 reference

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21 January 2018

An electrostatic engine model for autoinhibition and activation of the epidermal growth factor receptor (EGFR/ErbB) family

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21 January 2018

An allosteric mechanism for activation of the kinase domain of epidermal growth factor receptor

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Protein-protein interactions in the allosteric regulation of protein kinases

1 reference

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21 January 2018

Calmodulin regulates intracellular trafficking of epidermal growth factor receptor and the MAPK signaling pathway.

1 reference

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21 January 2018

Role of calmodulin in the modulation of the MAPK signalling pathway and the transactivation of epidermal growth factor receptor mediated by PKC.

1 reference

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21 January 2018

Lipid traffic: floppy drives and a superhighway.

1 reference

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21 January 2018

The electrostatic properties of membranes

1 reference

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21 January 2018

Measuring electrostatic potentials adjacent to membranes.

1 reference

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21 January 2018

The Effector Domain of Myristoylated Alanine-rich C Kinase Substrate Binds Strongly to Phosphatidylinositol 4,5-Bisphosphate

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21 January 2018

Fluorescence correlation spectroscopy studies of Peptide and protein binding to phospholipid vesicles

1 reference

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21 January 2018

Membrane-bound basic peptides sequester multivalent (PIP2), but not monovalent (PS), acidic lipids

1 reference

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21 January 2018

Fluorescence correlation spectroscopy. II. An experimental realization

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21 January 2018

Fluorescence correlation spectroscopy: diagnostics for sparse molecules

1 reference

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21 January 2018

Measuring diffusion in cell membranes by fluorescence correlation spectroscopy

1 reference

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21 January 2018

Quick tour of fluorescence correlation spectroscopy from its inception

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21 January 2018

Epidermal growth factor receptor interaction with clathrin adaptors is mediated by the Tyr974-containing internalization motif

1 reference

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21 January 2018

Endocytosis of functional epidermal growth factor receptor-green fluorescent protein chimera

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21 January 2018

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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21 January 2018

Role of calmodulin in platelet aggregation. Structure-activity relationship of calmodulin antagonists

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21 January 2018

Cations that alter surface potentials of lipid bilayers increase the calcium requirement for exocytosis in sea urchin eggs

1 reference

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21 January 2018

A fluorescent calmodulin that reports the binding of hydrophobic inhibitory ligands

1 reference

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21 January 2018

Swelling-induced K(+) fluxes in vascular smooth muscle cells are mediated by charybdotoxin-sensitive K(+) channels.

1 reference

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21 January 2018

Interactions between the juxtamembrane domain of the EGFR and calmodulin measured by surface plasmon resonance.

1 reference

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21 January 2018

Quantification of Short Term Signaling by the Epidermal Growth Factor Receptor

1 reference

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21 January 2018

Release of a phorbol ester-induced mitogenic block by mutation at Thr-654 of the epidermal growth factor receptor

1 reference

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21 January 2018

Ca2+/calmodulin-dependent kinase II phosphorylates the epidermal growth factor receptor on multiple sites in the cytoplasmic tail and serine 744 within the kinase domain to regulate signal generation

1 reference

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21 January 2018

Solution structure of calmodulin-W-7 complex: the basis of diversity in molecular recognition

1 reference

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21 January 2018

Membrane-protein interactions in cell signaling and membrane trafficking

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21 January 2018

A designed probe for acidic phospholipids reveals the unique enriched anionic character of the cytosolic face of the mammalian plasma membrane.

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21 January 2018

Ca2+/calmodulin-dependent translocation of sphingosine kinase: role in plasma membrane relocation but not activation.

1 reference

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21 January 2018

The calmodulin-binding site of sphingosine kinase and its role in agonist-dependent translocation of sphingosine kinase 1 to the plasma membrane

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21 January 2018

The mechanism of membrane targeting of human sphingosine kinase 1.

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Calmodulin binds to the basolateral targeting signal of the polymeric immunoglobulin receptor.

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Equilibrium and kinetic effects of drugs on the shapes of human erythrocytes

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Ca(2+) mobilization induced by W-7 in MG63 human osteosarcoma cells.

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Cell signaling by receptor tyrosine kinases

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Epidermal growth factor receptor: mechanisms of activation and signalling.

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1 reference

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Juxtamembrane autoinhibition in receptor tyrosine kinases.

1 reference

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A Putative Mechanism for Downregulation of the Catalytic Activity of the EGF Receptor via Direct Contact between Its Kinase and C-Terminal Domains

1 reference

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21 January 2018

Electrostatic interactions of peptides flanking the tyrosine kinase domain in the epidermal growth factor receptor provides a model for intracellular dimerization and autophosphorylation.

1 reference

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Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane

1 reference

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21 January 2018

Identifiers

10.1074/JBC.M607211200

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24 December 2019

1 reference

Europe PubMed Central

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24 December 2019

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