(Q57457576)

English

The Nuclear Receptor PPARγ Controls Progressive Macrophage Polarization as a Ligand-Insensitive Epigenomic Ratchet of Transcriptional Memory

scientific article published on 01 October 2018

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scholarly article

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29 April 2020

The Nuclear Receptor PPARγ Controls Progressive Macrophage Polarization as a Ligand-Insensitive Epigenomic Ratchet of Transcriptional Memory (English)

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29 April 2020

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29 April 2020

Andreas Patsalos

11

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29 April 2020

Balint L. Balint

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author name string

Bence Daniel

1

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Gergely Nagy

2

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Zsolt Czimmerer

3

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David W Hammers

5

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Ixchelt Cuaranta-Monroy

6

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Szilard Poliska

7

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Petros Tzerpos

8

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29 April 2020

Zsuzsanna Kolostyak

9

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Tristan T Hays

10

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29 April 2020

René Houtman

12

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29 April 2020

Sascha Sauer

13

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29 April 2020

Jean Francois-Deleuze

14

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29 April 2020

Fraydoon Rastinejad

15

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29 April 2020

H Lee Sweeney

17

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29 April 2020

Laszlo Nagy

18

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language of work or name

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publication date

1 October 2018

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29 April 2020

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49

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4

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615-626.e6

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describes a project that uses

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11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC6197058/fullTextXML

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Novel sequence determinants in peroxisome proliferator signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/30332629

12 December 2020

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The peroxisome proliferator-activated receptor:retinoid X receptor heterodimer is activated by fatty acids and fibrate hypolipidaemic drugs

1 reference

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12 December 2020

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Polarity and specific sequence requirements of peroxisome proliferator-activated receptor (PPAR)/retinoid X receptor heterodimer binding to DNA. A functional analysis of the malic enzyme gene PPAR response element

1 reference

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12 December 2020

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Interleukin-4-dependent production of PPAR-gamma ligands in macrophages by 12/15-lipoxygenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/30332629

12 December 2020

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Degradation of the peroxisome proliferator-activated receptor gamma is linked to ligand-dependent activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30332629

12 December 2020

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Capturing chromosome conformation

1 reference

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12 December 2020

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PPARgamma and PPARdelta negatively regulate specific subsets of lipopolysaccharide and IFN-gamma target genes in macrophages

1 reference

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12 December 2020

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Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30332629

12 December 2020

based on heuristic

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Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/30332629

12 December 2020

based on heuristic

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Fat and beyond: the diverse biology of PPARgamma

1 reference

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Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/30332629

12 December 2020

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The cohesin complex and its roles in chromosome biology

1 reference

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12 December 2020

based on heuristic

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Alternative activation of macrophages: an immunologic functional perspective

1 reference

https://pubmed.ncbi.nlm.nih.gov/30332629

12 December 2020

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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

1 reference

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12 December 2020

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Latent TGF-beta-binding protein 4 modifies muscular dystrophy in mice

1 reference

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12 December 2020

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Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities

1 reference

https://pubmed.ncbi.nlm.nih.gov/30332629

12 December 2020

based on heuristic

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Origin and evolution of the ligand-binding ability of nuclear receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/30332629

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STAT6 transcription factor is a facilitator of the nuclear receptor PPARγ-regulated gene expression in macrophages and dendritic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30332629

12 December 2020

based on heuristic

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A comprehensive view of nuclear receptor cancer cistromes

1 reference

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Nuclear hormone receptors enable macrophages and dendritic cells to sense their lipid environment and shape their immune response

1 reference

https://pubmed.ncbi.nlm.nih.gov/30332629

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based on heuristic

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Epigenetic regulation of macrophage polarization and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/30332629

12 December 2020

based on heuristic

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Latent enhancers activated by stimulation in differentiated cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30332629

12 December 2020

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Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30332629

12 December 2020

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Synergistic activation of inflammatory cytokine genes by interferon-γ-induced chromatin remodeling and toll-like receptor signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/30332629

12 December 2020

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Tissue-resident macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/30332629

12 December 2020

based on heuristic

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Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

1 reference

https://pubmed.ncbi.nlm.nih.gov/30332629

12 December 2020

based on heuristic

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Ligand binding shifts highly mobile retinoid X receptor to the chromatin-bound state in a coactivator-dependent manner, as revealed by single-cell imaging

1 reference

https://pubmed.ncbi.nlm.nih.gov/30332629

12 December 2020

based on heuristic

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The M1 and M2 paradigm of macrophage activation: time for reassessment

1 reference

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12 December 2020

based on heuristic

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Nuclear Receptors, RXR, and the Big Bang

1 reference

https://pubmed.ncbi.nlm.nih.gov/30332629

12 December 2020

based on heuristic

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Anti-diabetic rosiglitazone remodels the adipocyte transcriptome by redistributing transcription to PPARγ-driven enhancers

1 reference

https://pubmed.ncbi.nlm.nih.gov/30332629

12 December 2020

based on heuristic

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The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30332629

12 December 2020

based on heuristic

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Mapping the genomic binding sites of the activated retinoid X receptor in murine bone marrow-derived macrophages using chromatin immunoprecipitation sequencing

1 reference

https://pubmed.ncbi.nlm.nih.gov/30332629

12 December 2020

based on heuristic

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Induction of the nuclear receptor PPAR-γ by the cytokine GM-CSF is critical for the differentiation of fetal monocytes into alveolar macrophages.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30332629

12 December 2020

based on heuristic

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Molecular control of activation and priming in macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/30332629

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Macrophage PPARγ, a Lipid Activated Transcription Factor Controls the Growth Factor GDF3 and Skeletal Muscle Regeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/30332629

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based on heuristic

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Targeting PPARγ in the epigenome rescues genetic metabolic defects in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30332629

12 December 2020

based on heuristic

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Opposing macrophage polarization programs show extensive epigenomic and transcriptional cross-talk

1 reference

https://pubmed.ncbi.nlm.nih.gov/30332629

12 December 2020

based on heuristic

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In situ macrophage phenotypic transition is affected by altered cellular composition prior to acute sterile muscle injury.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30332629

12 December 2020

based on heuristic

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Interferon-γ Represses M2 Gene Expression in Human Macrophages by Disassembling Enhancers Bound by the Transcription Factor MAF.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30332629

12 December 2020

based on heuristic

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Type I interferons and the cytokine TNF cooperatively reprogram the macrophage epigenome to promote inflammatory activation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30332629

12 December 2020

based on heuristic

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The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30332629

12 December 2020

based on heuristic

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The IL-4/STAT6/PPARγ signaling axis is driving the expansion of the RXR heterodimer cistrome, providing complex ligand responsiveness in macrophages.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30332629

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1 reference

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Identifiers

10.1016/J.IMMUNI.2018.09.005

1 reference

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29 April 2020

1 reference

Europe PubMed Central

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29 April 2020

1 reference

Europe PubMed Central

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