(Q57708485)

English

Improving Potency, Selectivity, and Water Solubility of Adenosine A1 Receptor Antagonists: Xanthines Modified at Position 3 and Related Pyrimido[1,2,3-cd]purinediones

scientific article published on 01 August 2006

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16902942%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

Improving potency, selectivity, and water solubility of adenosine A1 receptor antagonists: xanthines modified at position 3 and related pyrimido[1,2,3-cd]purinediones (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16902942%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

molecular medicine

0 references

Karl-Norbert Klotz

6

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16902942%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

Christa E Müller

7

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16902942%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

author name string

Stefanie Weyler

1

1 reference

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16902942%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

Friederike Fülle

2

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16902942%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

Martina Diekmann

3

1 reference

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28 December 2019

Britta Schumacher

4

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16902942%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

Sonja Hinz

5

1 reference

Europe PubMed Central

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28 December 2019

publication date

1 August 2006

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16902942%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16902942%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

1

1 reference

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28 December 2019

8

1 reference

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28 December 2019

891-902

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16902942%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

Adenosine receptor ligands-recent developments part I. Agonists

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600066

21 January 2018

Adenosine receptor agonists: from basic medicinal chemistry to clinical development

1 reference

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A2A adenosine receptor antagonists - future drugs for Parkinson's disease?

1 reference

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7 January 2021

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A2B adenosine receptor antagonists: recent developments

1 reference

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7 January 2021

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Antinociceptive effects of novel A2B adenosine receptor antagonists.

1 reference

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7 January 2021

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Medicinal chemistry of adenosine A3 receptor ligands

1 reference

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7 January 2021

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Adenosine A1 receptor antagonists and the kidney

1 reference

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7 January 2021

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Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600066

7 January 2021

based on heuristic

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Medicinal chemistry of adenosine A1 receptor ligands

1 reference

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7 January 2021

based on heuristic

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Historical review: Negative efficacy and the constitutive activity of G-protein-coupled receptors.

1 reference

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7 January 2021

based on heuristic

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2,4,6-trisubstituted pyrimidines as a new class of selective adenosine A1 receptor antagonists.

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600066

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis and structure-activity relationships of 3,7-dimethyl-1-propargylxanthine derivatives, A2A-selective adenosine receptor antagonists

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600066

7 January 2021

based on heuristic

inferred from DOI database lookup

Der synthetische Aufbau der Harnsäure, des Xanthins, Theobromins, Theophyllins und Caffeïns aus der Cyanessigsäure

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600066

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis of paraxanthine analogs (1,7-disubstituted xanthines) and other xanthines unsubstituted at the 3-position: structure-activity relationships at adenosine receptors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600066

7 January 2021

based on heuristic

inferred from DOI database lookup

Multigram-scale syntheses, stability, and photoreactions of A2A adenosine receptor antagonists with 8-styrylxanthine structure: potential drugs for Parkinson's disease

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600066

7 January 2021

based on heuristic

inferred from DOI database lookup

Versatile, convenient synthesis of pyrimido[1,2,3-cd]purinediones

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600066

7 January 2021

based on heuristic

inferred from DOI database lookup

Water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, A(2A)-selective adenosine receptor antagonists

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600066

7 January 2021

based on heuristic

inferred from DOI database lookup

1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600066

7 January 2021

based on heuristic

inferred from DOI database lookup

Adenosine receptors: pharmacology, structure-activity relationships, and therapeutic potential

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600066

7 January 2021

based on heuristic

inferred from DOI database lookup

Motor effects induced by a blockade of adenosine A2A receptors in the caudate-putamen

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600066

7 January 2021

based on heuristic

inferred from DOI database lookup

A detailed behavioral analysis of the acute motor effects of caffeine in the rat: involvement of adenosine A1 and A2A receptors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600066

7 January 2021

based on heuristic

inferred from DOI database lookup

Effects of an adenosine A2A receptor blockade in the nucleus accumbens on locomotion, feeding, and prepulse inhibition in rats

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600066

7 January 2021

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inferred from DOI database lookup

Catalepsy induced by a blockade of dopamine D1 or D2 receptors was reversed by a concomitant blockade of adenosine A(2A) receptors in the caudate-putamen of rats

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600066

7 January 2021

based on heuristic

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Electrophysiological and behavioural evidence for an antagonistic modulatory role of adenosine A2Areceptors in dopamine D2receptor regulation in the rat dopamine-denervated striatum

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600066

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis and biological evaluation of CX-659S and its related compounds for their inhibitory effects on the delayed-type hypersensitivity reaction

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600066

7 January 2021

based on heuristic

inferred from DOI database lookup

[(3)H]8-Ethyl-4-methyl-2-phenyl-(8R)-4,5,7,8-tetrahydro-1H-imidazo[2,1-i]-purin-5-one ([(3)H]PSB-11), a novel high-affinity antagonist radioligand for human A(3) adenosine receptors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600066

7 January 2021

based on heuristic

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2-Chloro-N6-[3H]cyclopentyladenosine ([3H]CCPA)--a high affinity agonist radioligand for A1 adenosine receptors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600066

7 January 2021

based on heuristic

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Binding of [3H]MSX-2 (3-(3-hydroxypropyl)-7-methyl-8-(m-methoxystyryl)-1-propargylxanthine) to rat striatal membranes--a new, selective antagonist radioligand for A(2A) adenosine receptors

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600066

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis and pharmacology of pyrido[2,3-d]pyrimidinediones bearing polar substituents as adenosine receptor antagonists

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600066

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthesis and biological evaluation of the enantiomers of the potent and selective A1-adenosine antagonist 1,3-dipropyl-8-[2-(5,6-epoxynorbonyl)]-xanthine

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600066

7 January 2021

based on heuristic

inferred from DOI database lookup

Adenosine receptors and their modulators

1 reference

https://api.crossref.org/works/10.1002%2FCMDC.200600066

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1002/CMDC.200600066

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16902942%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16902942%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

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