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Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias

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1 January 2020

Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias (English)

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1 January 2020

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acute myeloid leukemia

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childhood acute myeloid leukemia

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Charles G. Mullighan

1

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1 January 2020

author name string

A Kennedy

2

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1 January 2020

X Zhou

3

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1 January 2020

I Radtke

4

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1 January 2020

L A Phillips

5

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S A Shurtleff

6

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1 January 2020

J R Downing

7

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publication date

28 June 2007

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1 January 2020

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1 January 2020

21

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1 January 2020

2000-2009

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9

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1 January 2020

https://scigraph.springernature.com/pub.10.1038/sj.leu.2404808

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Activating mutations of RTK/ras signal transduction pathway in pediatric acute myeloid leukemia

1 reference

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Mutations in KIT and RAS are frequent events in pediatric core-binding factor acute myeloid leukemia

1 reference

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Prognostic significance of FLT3 mutations in pediatric non-promyelocytic acute myeloid leukemia

1 reference

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Prognostic significance of partial tandem duplications of the MLL gene in adult patients 16 to 60 years old with acute myeloid leukemia and normal cytogenetics: a study of the Acute Myeloid Leukemia Study Group Ulm.

1 reference

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Prevalence, clinical profile, and prognosis of NPM mutations in AML with normal karyotype

1 reference

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21 January 2018

Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations

1 reference

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21 January 2018

Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype

1 reference

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21 January 2018

Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype

1 reference

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Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance

1 reference

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Major nucleolar proteins shuttle between nucleus and cytoplasm

1 reference

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21 January 2018

ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway

1 reference

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21 January 2018

Nucleophosmin regulates the stability and transcriptional activity of p53

1 reference

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21 January 2018

Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma.

1 reference

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21 January 2018

Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis

1 reference

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21 January 2018

Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404808

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Gene expression profiling of pediatric acute myelogenous leukemia.

1 reference

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21 January 2018

Classification of pediatric acute lymphoblastic leukemia by gene expression profiling

1 reference

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21 January 2018

MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404808

21 January 2018

Successive clinical trials for childhood acute myeloid leukemia at St Jude Children's Research Hospital, from 1980 to 2000.

1 reference

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21 January 2018

Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French-American-British Cooperative Group

1 reference

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21 January 2018

A direct approach to false discovery rates

1 reference

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21 January 2018

Statistical significance for genomewide studies

1 reference

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21 January 2018

Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples

1 reference

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The role of HOX genes in myeloid leukemogenesis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404808

21 January 2018

Hox regulation of normal and leukemic hematopoietic stem cells.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404808

21 January 2018

Hox expression in AML identifies a distinct subset of patients with intermediate cytogenetics

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404808

21 January 2018

Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404808

21 January 2018

Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404808

21 January 2018

Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404808

21 January 2018

Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404808

21 January 2018

Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemia

1 reference

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HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404808

21 January 2018

Expression pattern of HOXB6 homeobox gene in myelomonocytic differentiation and acute myeloid leukemia.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404808

21 January 2018

Mutated nucleophosmin detects clonal multilineage involvement in acute myeloid leukemia: Impact on WHO classification

1 reference

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21 January 2018

Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo

1 reference

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21 January 2018

HOXB4-induced expansion of adult hematopoietic stem cells ex vivo.

1 reference

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Nucleophosmin and cancer

1 reference

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Immunohistochemistry predicts nucleophosmin (NPM) mutations in acute myeloid leukemia

1 reference

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Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance

1 reference

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21 January 2018

CEBPalpha mutations in childhood acute myeloid leukemia

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Screening for MLL tandem duplication in 387 unselected patients with AML identify a prognostically unfavorable subset of AML

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404808

7 January 2021

based on heuristic

inferred from DOI database lookup

Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404808

7 January 2021

based on heuristic

inferred from DOI database lookup

Nucleophosmin mutations in childhood acute myelogenous leukemia with normal karyotype

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404808

7 January 2021

based on heuristic

inferred from DOI database lookup

NPM mutations in acute myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404808

7 January 2021

based on heuristic

inferred from DOI database lookup

Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404808

7 January 2021

based on heuristic

inferred from DOI database lookup

Nonparametric Estimation from Incomplete Observations

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404808

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404808

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/SJ.LEU.2404808

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17597811%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17597811%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

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