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What makes a good genetic association study?
scientific article published in The Lancet
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1 reference
stated in
Europe PubMed Central
PubMed ID
16214603
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16214603%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 January 2020
title
What makes a good genetic association study?
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
16214603
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16214603%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 January 2020
author
Mark McCarthy
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
16214603
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16214603%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 January 2020
author name string
Andrew T Hattersley
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
16214603
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16214603%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 January 2020
language of work or name
English
0 references
publication date
1 October 2005
1 reference
stated in
Europe PubMed Central
PubMed ID
16214603
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16214603%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 January 2020
published in
The Lancet
1 reference
stated in
Europe PubMed Central
PubMed ID
16214603
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16214603%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 January 2020
volume
366
1 reference
stated in
Europe PubMed Central
PubMed ID
16214603
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16214603%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 January 2020
page(s)
1315-1323
1 reference
stated in
Europe PubMed Central
PubMed ID
16214603
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16214603%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 January 2020
issue
9493
1 reference
stated in
Europe PubMed Central
PubMed ID
16214603
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16214603%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 January 2020
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Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease
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Replication validity of genetic association studies
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A comprehensive review of genetic association studies
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Problems of reporting genetic associations with complex outcomes
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Reporting, appraising, and integrating data on genotype prevalence and gene-disease associations
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Genetic association studies
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Population stratification and spurious allelic association
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Genomewide scans of complex human diseases: true linkage is hard to find
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The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
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Mutation in blood coagulation factor V associated with resistance to activated protein C.
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Meta-analysis of COL1A1 Sp1 polymorphism in relation to bone mineral density and osteoporotic fracture
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A COL1A1 Sp1 binding site polymorphism predisposes to osteoporotic fracture by affecting bone density and quality
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Strong association of the Y402H variant in complement factor H at 1q32 with susceptibility to age-related macular degeneration
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A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration
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Complement factor H variant increases the risk of age-related macular degeneration
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Complement factor H polymorphism in age-related macular degeneration
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Complement factor H polymorphism and age-related macular degeneration
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Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes
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Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
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Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups
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CTLA-4 and its role in autoimmune thyroid disease
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Human type 1 diabetes and the insulin gene: principles of mapping polygenes
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Pooled analysis and meta-analysis of glutathione S-transferase M1 and bladder cancer: a HuGE review
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An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing
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Progress in defining the molecular basis of type 2 diabetes mellitus through susceptibility-gene identification
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Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility
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New methods for finding disease-susceptibility genes: impact and potential
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Haplotype tagging for the identification of common disease genes
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Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium
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Linkage disequilibrium and the mapping of complex human traits.
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On the allelic spectrum of human disease
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7 January 2021
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The structure of haplotype blocks in the human genome
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Candidate-gene approaches for studying complex genetic traits: practical considerations
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Wanted: regulatory SNPs
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Genetic variation near the hepatocyte nuclear factor-4 alpha gene predicts susceptibility to type 2 diabetes.
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A common polymorphism in the upstream promoter region of the hepatocyte nuclear factor-4 alpha gene on chromosome 20q is associated with type 2 diabetes and appears to contribute to the evidence for linkage in an ashkenazi jewish population.
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A distant upstream promoter of the HNF-4alpha gene connects the transcription factors involved in maturity-onset diabetes of the young
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7 January 2021
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A transcription factor regulatory circuit in differentiated pancreatic cells
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In vivo characterization of regulatory polymorphisms by allele-specific quantification of RNA polymerase loading
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Mapping complex disease loci in whole-genome association studies
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Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction
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Gly972Arg variant in the insulin receptor substrate-1 gene and association with Type 2 diabetes: a meta-analysis of 27 studies
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Young-onset type 2 diabetes families are the major contributors to genetic loci in the Diabetes UK Warren 2 genome scan and identify putative novel loci on chromosomes 8q21, 21q22, and 22q11.
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Increasing the power and efficiency of disease-marker case-control association studies through use of allele-sharing information
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The power of genomic control
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Population-based family studies in genetic epidemiology
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Estimating sample sizes for binary, ordered categorical, and continuous outcomes in two group comparisons
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Assessing the probability that a positive report is false: an approach for molecular epidemiology studies
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The effects of human population structure on large genetic association studies
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Evaluation of single nucleotide polymorphism typing with invader on PCR amplicons and its automation
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Clinical epidemiological quality in molecular genetic research: the need for methodological standards
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What SNP genotyping errors are most costly for genetic association studies?
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Power and sample size calculations for case-control genetic association tests when errors are present: application to single nucleotide polymorphisms.
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Effect of the statistical significance of results on the time to completion and publication of randomized efficacy trials
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Impact of genotyping errors on type I error rate of the haplotype-sharing transmission/disequilibrium test (HS-TDT).
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Undetected genotyping errors cause apparent overtransmission of common alleles in the transmission/disequilibrium test
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The impact of genotyping error on haplotype reconstruction and frequency estimation
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Identification and analysis of error types in high-throughput genotyping
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7 January 2021
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A comparison of bayesian methods for haplotype reconstruction from population genotype data
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7 January 2021
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Bayesian haplotype inference for multiple linked single-nucleotide polymorphisms
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A New Statistical Method for Haplotype Reconstruction from Population Data
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Caution on pedigree haplotype inference with software that assumes linkage equilibrium
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"Are we there yet?": Deciding when one has demonstrated specific genetic causation in complex diseases and quantitative traits.
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7 January 2021
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Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results
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7 January 2021
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Large-scale test of hypothesised associations between the angiotensin-converting-enzyme insertion/deletion polymorphism and myocardial infarction in about 5000 cases and 6000 controls. International Studies of Infarct Survival (ISIS) Collaborators
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7 January 2021
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Nonreplication in Genetic Association Studies of Obesity and Diabetes Research
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7 January 2021
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Statistical significance for genomewide studies
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7 January 2021
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A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other
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7 January 2021
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General score tests for associations of genetic markers with disease using cases and their parents.
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7 January 2021
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Inference on haplotype effects in case-control studies using unphased genotype data
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7 January 2021
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Multiple comparisons in studies of gene x gene and gene x environment interaction
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7 January 2021
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Methods for detection of parent-of-origin effects in genetic studies of case-parents triads
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7 January 2021
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Statistical significance in psychological research
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7 January 2021
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Identifiers
DOI
10.1016/S0140-6736(05)67531-9
1 reference
stated in
Europe PubMed Central
PubMed ID
16214603
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16214603%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 January 2020
PubMed ID
16214603
1 reference
stated in
Europe PubMed Central
PubMed ID
16214603
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16214603%20AND%20SRC:MED&resulttype=core&format=json
retrieved
7 January 2020
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