(Q57951324)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10668183%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

title

Structure-activity studies on nociceptin/orphanin FQ: from full agonist, to partial agonist, to pure antagonist (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10668183%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

0 references

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10668183%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

Remo Guerrini

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10668183%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

author name string

G Calo

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10668183%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

D Regoli

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10668183%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

publication date

1 November 1999

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10668183%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10668183%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

volume

54

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10668183%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

issue

11-12

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10668183%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

page(s)

810-825

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10668183%20AND%20SRC:MED&resulttype=core&format=json

Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a mu, delta or kappa opioid receptor type

3 November 2019

cites work

1 reference

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Isolation of a novel cDNA encoding a putative membrane receptor with high homology to the cloned mu, delta, and kappa opioid receptors.

7 January 2021

1 reference

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cDNA cloning of an orphan opiate receptor gene family member and its splice variant

7 January 2021

1 reference

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Cloning, expression and functional role of a nociceptin/orphanin FQ receptor in the porcine gastrointestinal tract

7 January 2021

1 reference

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ORL1, a novel member of the opioid receptor family. Cloning, functional expression and localization

7 January 2021

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Molecular cloning, tissue distribution and chromosomal localization of a novel member of the opioid receptor gene family

7 January 2021

1 reference

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Orphanin FQ: a neuropeptide that activates an opioidlike G protein-coupled receptor.

7 January 2021

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Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor

7 January 2021

1 reference

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Identification of opioid receptor-like (ORL1) peptide-stimulated [35S]GTP gamma S binding in rat brain.

7 January 2021

1 reference

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Anatomical distribution of mu, delta, and kappa opioid- and nociceptin/orphanin FQ-stimulated [35S]guanylyl-5'-O-(gamma-thio)-triphosphate binding in guinea pig brain

7 January 2021

1 reference

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Distribution of nociceptin/orphanin FQ receptor transcript in human central nervous system and immune cells.

7 January 2021

1 reference

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Functional role and sequence analysis of a lymphocyte orphan opioid receptor

7 January 2021

1 reference

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Reverse physiology: discovery of the novel neuropeptide, orphanin FQ/nociceptin

7 January 2021

1 reference

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Nociceptin/orphanin FQ and the opioid receptor-like ORL1 receptor

7 January 2021

1 reference

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Nociceptin/orphanin FQ: role in nociceptive information processing

7 January 2021

1 reference

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Nociceptin/orphanin FQ microinjected into hippocampus impairs spatial learning in rats.

7 January 2021

1 reference

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Facilitation of long-term potentiation and memory in mice lacking nociceptin receptors.

7 January 2021

1 reference

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Injections of nociceptin into nucleus accumbens shell or ventromedial hypothalamic nucleus increase food intake.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Orphanin FQ stimulates prolactin and growth hormone release in male and female rats.

7 January 2021

1 reference

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Inhibition of rat oxytocin and vasopressin supraoptic nucleus neurons by nociceptin in vitro.

7 January 2021

1 reference

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Determination of activity for nociceptin in the mouse vas deferens

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Naloxone-insensitive inhibition of acetylcholine release from parasympathetic nerves innervating guinea-pig trachea by the novel opioid, nociceptin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Inhibition of tachykinin release from peripheral endings of sensory nerves by nociceptin, a novel opioid peptide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Prejunctional modulation by nociceptin of nerve-mediated inotropic responses in guinea-pig left atrium

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Inhibition by nociceptin of neurogenic inflammation and the release of SP and CGRP from sensory nerve terminals

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Effect of nociceptin on heart rate and blood pressure in anaesthetized rats.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

The inhibitory effect of nociceptin on the micturition reflex in anaesthetized rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Structure, tissue distribution, and chromosomal localization of the prepronociceptin gene

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Primary structure and tissue distribution of the orphanin FQ precursor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Nocistatin, a peptide that blocks nociceptin action in pain transmission

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Bivalent ligands and the message-address concept in the design of selective opioid receptor antagonists

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Estimated conformation, orientation, and accumulation of dynorphin A-(1-13)-tridecapeptide on the surface of neutral lipid membranes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Structures that delineate orphanin FQ and dynorphin A pharmacological selectivities

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Different domains of the ORL1 and kappa-opioid receptors are involved in recognition of nociceptin and dynorphin A.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Molecular modelling of the ORL1 receptor and its complex with nociceptin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Orphanin FQ: receptor binding and analog structure activity relationships in rat brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Recognition and activation of the opioid receptor-like ORL 1 receptor by nociceptin, nociceptin analogs and opioids

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Comparison of the effects of [Phe1psi(CH2-NH)Gly2]nociceptin(1-13)NH2 in rat brain, rat vas deferens and CHO cells expressing recombinant human nociceptin receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Structure-activity relationship studies on the novel neuropeptide orphanin FQ.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Biochemical evidence for orphanin FQ/nociceptin receptor heterogeneity in mouse brain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Nociceptin receptor binding in mouse forebrain membranes: thermodynamic characteristics and structure activity relationships

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Relationship between binding affinity and functional activity of nociceptin/orphanin FQ.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

The mouse vas deferens: a pharmacological preparation sensitive to nociceptin

7 January 2021

1 reference

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Nociceptin receptor activation inhibits tachykinergic non adrenergic non cholinergic contraction of guinea pig isolated bronchus.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Effect of morphine on adrenergic transmission in the mouse vas deferens. Assessment of agonist and antogonist potencies of narcotic analgesics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Orphanin FQ is a functional anti-opioid peptide.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Functional antagonism of mu-, delta- and kappa-opioid antinociception by orphanin FQ.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Nociceptin receptor coupling to a potassium conductance in rat locus coeruleus neurones in vitro

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

The effect of nociceptin on Ca2+ channel current and intracellular Ca2+ in the SH-SY5Y human neuroblastoma cell line

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Nociceptin in vitro biotransformation in human blood

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Association of aminopeptidase N and endopeptidase 24.15 inhibitors potentiate behavioral effects mediated by nociceptin/orphanin FQ in mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

In vivo metabolism of nociceptin/orphanin FQ in rat hippocampus.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Biotransformation of nociceptin/orphanin FQ by enzyme activity from morphine-naive and morphine-treated cell cultures.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Characterization of nociceptin receptors in the periphery: in vitro and in vivo studies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Pharmacological characterization of the nociceptin receptor mediating hyperalgesia in the mouse tail withdrawal assay

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Cardiovascular effects of nociceptin in unanesthetized mice

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Address and message sequences for the nociceptin receptor: a structure-activity study of nociceptin-(1-13)-peptide amide.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Structure−Activity Study of the Nociceptin(1−13)-NH2N-Terminal Tetrapeptide and Discovery of a Nociceptin Receptor Antagonist

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Sensitivity of opioid receptor-like receptor ORL1 for chemical modification on nociceptin, a naturally occurring nociceptive peptide

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Specific receptor for the opioid peptide dynorphin: structure--activity relationships

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Structure and function of G protein-coupled receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Recent developments in the design of receptor specific opioid peptides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Structure-Activity Relationships of Enkephalin-Like Peptides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

N-terminal alkylated derivatives of [D-Pro10]dynorphin A-(1-11) are highly selective for kappa-opioid receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Selective antagonists at the opiate delta-receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Subtleties of structure-agonist versus antagonist relationships of opioid peptides and peptidomimetics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Selective opioid dipeptides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

New delta-opioid antagonists as pharmacological probes.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

A new selective antagonist of the nociceptin receptor.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

The cloned mu, delta and kappa receptors and their endogenous ligands: evidence for two opioid peptide recognition cores

7 January 2021

1 reference

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Differential stereochemical requirements of mu vs. delta opioid receptors for ligand binding and signal transduction: development of a class of potent and highly delta-selective peptide antagonists

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Conformationally restricted analogs of somatostatin with high mu-opiate receptor specificity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Acetalins: opioid receptor antagonists determined through the use of synthetic peptide combinatorial libraries

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Pharmacology of [Tyr1]nociceptin analogs: receptor binding and bioassay studies

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Effects of sigma ligands on the nociceptin/orphanin FQ receptor co-expressed with the G-protein-activated K+ channel in Xenopus oocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Loss of antinociception induced by naloxone benzoylhydrazone in nociceptin receptor-knockout mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Nociceptin inhibits noradrenaline release in the mouse brain cortex via presynaptic ORL1 receptors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Nociceptin inhibits non-adrenergic non-cholinergic contraction in guinea-pig airway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

The nociceptin receptor-mediated inhibition of the rat rostral ventrolateral medulla neurons in vitro.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

[Phe1phi(CH2-NH)Gly2]nociceptin-(1-13)-NH2 acts as a partial agonist at ORL1 receptor endogenously expressed in mouse N1E-115 neuroblastoma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

[Phe1psi(CH2-NH)Gly2]-nociceptin-(1-13)NH2, a proposed antagonist of the nociceptin receptor, is a potent and stable agonist in the rat spinal cord.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

[Phe1psi(CH2-NH)Gly2]nociceptin-(1-13)-NH2 acts as an agonist of the orphanin FQ/nociceptin receptor in vivo

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Evidence that [Phe1 psi(CH2-NH)Gly2]nociceptin-(1-13)-NH2, a peripheral ORL-1 receptor antagonist, acts as an agonist in the rat spinal cord

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

[Phe1psi(CH2-NH)Gly2]nociceptin-(1-13)-NH2 is an agonist of the nociceptin (ORL1) receptor.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Agonistic effect of buprenorphine in a nociceptin/OFQ receptor-triggered reporter gene assay

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Peptoids: a modular approach to drug discovery.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

The 'peptoid' approach to the design of non-peptide, small molecule agonists and antagonists of neuropeptides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Discovery of nanomolar ligands for 7-transmembrane G-protein-coupled receptors from a diverse N-(substituted)glycine peptoid library

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

The stereoselective kappa-opioid receptor antagonist Mr 2266 does not exhibit stereoselectivity as an antagonist at the orphan opioid (ORL1) receptor

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Designing peptide mimetics

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

Molecular cloning of a novel G protein-coupled receptor related to the opiate receptor family

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

inferred from DOI database lookup

7 January 2021

based on heuristic

Nociceptin/orphanin FQ metabolism: role of aminopeptidase and endopeptidase 24.15.

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

inferred from DOI database lookup

7 January 2021

based on heuristic

Chemical structures and biological activities of non-peptide selective kappa opioid ligands

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2899%2900108-1

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0014-827X(99)00108-1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10668183%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

1 reference