(Q58058093)

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An RGD to LDV Motif Conversion within the Disintegrin Kistrin Generates an Integrin Antagonist That Retains Potency but Exhibits Altered Receptor Specificity

scientific article published in Journal of Biological Chemistry

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9261147%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

An RGD to LDV motif conversion within the disintegrin kistrin generates an integrin antagonist that retains potency but exhibits altered receptor specificity. Evidence for a functional equivalence of acidic integrin-binding motifs (English)

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9261147%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

Martin J. Humphries

3

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9261147%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

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V H Tselepis

1

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9261147%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

L J Green

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9261147%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

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1 August 1997

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9261147%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

Journal of Biological Chemistry

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9261147%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

272

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5 November 2019

34

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5 November 2019

21341-21348

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9261147%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

Integrins: versatility, modulation, and signaling in cell adhesion

1 reference

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21 January 2018

Integrins: emerging paradigms of signal transduction

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Integrin transmembrane signaling and cytoskeletal control

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21 January 2018

Integrin activation: the link between ligand binding and signal transduction

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21 January 2018

Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule

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21 January 2018

Dualistic nature of adhesive protein function: fibronectin and its biologically active peptide fragments can autoinhibit fibronectin function

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Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin

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21 January 2018

Arrangement of domains, and amino acid residues required for binding of vascular cell adhesion molecule-1 to its counter-receptor VLA-4 (alpha 4 beta 1).

1 reference

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21 January 2018

Structural requirements for adhesion of soluble recombinant murine vascular cell adhesion molecule-1 to alpha 4 beta 1.

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21 January 2018

Residues within a conserved amino acid motif of domains 1 and 4 of VCAM-1 are required for binding to VLA-4

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21 January 2018

The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus

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21 January 2018

Analysis of the binding site on intercellular adhesion molecule 3 for the leukocyte integrin lymphocyte function-associated antigen 1.

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21 January 2018

Overview Biologicals and Immunologicals: Integrin antagonists as modulators of adhesion

1 reference

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21 January 2018

Engineering of artificial cell-adhesive proteins by grafting EILDVPST sequence derived from fibronectin

1 reference

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21 January 2018

Identification of novel peptide antagonists for GPIIb/IIIa from a conformationally constrained phage peptide library

1 reference

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21 January 2018

Structure, function and evolutionary relationship of proteins containing a disintegrin domain

1 reference

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21 January 2018

Structural and functional aspects of RGD-containing protein antagonists of glycoprotein IIb-IIIa

1 reference

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21 January 2018

Platelet glycoprotein IIb-IIIa protein antagonists from snake venoms: evidence for a family of platelet-aggregation inhibitors

1 reference

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21 January 2018

Batroxostatin, an Arg-Gly-Asp-containing peptide from Bothrops atrox, is a potent inhibitor of platelet aggregation and cell interaction with fibronectin

1 reference

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21 January 2018

Solution Structure of Kistrin, a Potent Platelet Aggregation Inhibitor and GP IIb-IIIa Antagonist

1 reference

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21 January 2018

Analysis of fibronectin receptor function with monoclonal antibodies: roles in cell adhesion, migration, matrix assembly, and cytoskeletal organization

1 reference

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21 January 2018

Fibronectin receptors of mononuclear phagocytes: binding characteristics and biochemical isolation.

1 reference

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21 January 2018

The Inhibitory Anti-β1 Integrin Monoclonal Antibody 13 Recognizes an Epitope That Is Attenuated by Ligand Occupancy

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21 January 2018

Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase

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21 January 2018

Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa

1 reference

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21 January 2018

The vitronectin receptor alpha v beta 3 binds fibronectin and acts in concert with alpha 5 beta 1 in promoting cellular attachment and spreading on fibronectin

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21 January 2018

Identification of an alternatively spliced site in human plasma fibronectin that mediates cell type-specific adhesion

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21 January 2018

Isolation of a highly specific ligand for the alpha 5 beta 1 integrin from a phage display library.

1 reference

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21 January 2018

Peptide ligands for integrin alpha v beta 3 selected from random phage display libraries

1 reference

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21 January 2018

Binding interactions of kistrin with platelet glycoprotein IIb-IIIa: analysis by site-directed mutagenesis.

1 reference

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21 January 2018

Preferential antagonism of the interactions of the integrin alpha IIb beta 3 with immobilized glycoprotein ligands by snake-venom RGD (Arg-Gly-Asp) proteins. Evidence supporting a functional role for the amino acid residues flanking the tripeptide R

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21 January 2018

The integrin alpha IIb beta 3 contains distinct and interacting binding sites for snake-venom RGD (Arg-Gly-Asp) proteins. Evidence that the receptor-binding characteristics of snake-venom RGD proteins are related to the amino acid environment flanki

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21 January 2018

Substitutions of proline 42 to alanine and methionine 46 to asparagine around the RGD domain of the neurotoxin dendroaspin alter its preferential antagonism to that resembling the disintegrin elegantin.

1 reference

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21 January 2018

A beta 3 integrin mutation abolishes ligand binding and alters divalent cation-dependent conformation

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21 January 2018

21 Snake venom metalloendopeptidases: Reprolysins

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21 January 2018

ADAM, a widely distributed and developmentally regulated gene family encoding membrane proteins with a disintegrin and metalloprotease domain

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21 January 2018

Metargidin, a membrane-anchored metalloprotease-disintegrin protein with an RGD integrin binding sequence

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Platelet receptor recognition site on human fibrinogen. Synthesis and structure-function relationship of peptides corresponding to the carboxy-terminal segment of the .gamma. chain

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21 January 2018

Trigramin, an RGD-containing peptide from snake venom, inhibits cell-substratum adhesion of human melanoma cells

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21 January 2018

Inhibition of integrin-ligand binding by recombinant kistrins

1 reference

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21 January 2018

Identification of the disulfide bond pattern in albolabrin, an RGD-containing peptide from the venon of trimeresurus albolabris: Significance for the express of platelet aggregation inhibitory activity

1 reference

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21 January 2018

Identifiers

10.1074/JBC.272.34.21341

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9261147%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9261147%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

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