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The design and synthesis of nucleoside triphosphate isosteres as potential inhibitors of HIV reverse transcriptase

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The design and synthesis of nucleoside triphosphate isosteres as potential inhibitors of HIV reverse transcriptase (English)

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author name string

Richard Weaver

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1

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Ian H. Gilbert

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2

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publication date

April 1997

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published in

Tetrahedron

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volume

53

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issue

15

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page(s)

5537-5562

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cites work

Initial studies on the cellular pharmacology of 2',3-dideoxycytidine, an inhibitor of HTLV-III infectivity.

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Initial studies on the cellular pharmacology of 2',3'-dideoxyinosine, an inhibitor of HIV infectivity

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(-)-2'-deoxy-3'-thiacytidine is a potent, highly selective inhibitor of human immunodeficiency virus type 1 and type 2 replication in vitro

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7 January 2021

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HIV inhibitors targeted at the reverse transcriptase

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Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance

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An expanded model of replicating human immunodeficiency virus reverse transcriptase

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Insights into DNA polymerization mechanisms from structure and function analysis of HIV-1 reverse transcriptase

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Glutamine 151 participates in the substrate dNTP binding function of HIV-1 reverse transcriptase

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Mononucleoside phosphotriester derivatives with S-acyl-2-thioethyl bioreversible phosphate-protecting groups: intracellular delivery of 3'-azido-2',3'-dideoxythymidine 5'-monophosphate

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Isosteres of nucleoside triphosphates

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Lipophilic bioisosteres of nucleoside triphosphates

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Nucleosides. IX. The Formation of 2',3'-Unsaturated Pyrimidine Nucleosides via a Novel β-Elimination Reaction1,2

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Synthesis of the Glycopeptide Partial Sequence A80-A84 of Human Fibroblast Interferon

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DOI

10.1016/S0040-4020(97)00210-X

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(Q58851585)

The design and synthesis of nucleoside triphosphate isosteres as potential inhibitors of HIV reverse transcriptase

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