(Q59244602)

English

Design, synthesis and biological evaluation of new 3-[(4-aryl)piperazin-1-yl]-1-arylpropane derivatives as potential antidepressants with a dual mode of action: serotonin reuptake inhibition and 5-HT1A receptor antagonism

scientific article published on 01 May 2000

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scholarly article

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10 November 2019

Design, synthesis and biological evaluation of new 3-[(4-aryl)piperazin-1-yl]-1-arylpropane derivatives as potential antidepressants with a dual mode of action: serotonin reuptake inhibition and 5-HT1A receptor antagonism (English)

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10 November 2019

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10 November 2019

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10 November 2019

author name string

J Martinez

2

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10 November 2019

S Pérez

3

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10 November 2019

M Irurzun

5

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10 November 2019

B Lasheras

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10 November 2019

A Monge

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10 November 2019

A M Oficialdegui

1

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10 November 2019

J A Palop

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10 November 2019

J del Río

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10 November 2019

publication date

1 May 2000

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10 November 2019

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10 November 2019

55

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10 November 2019

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10 November 2019

345-353

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10 November 2019

Serotonin reuptake antidepressant effects on sexual function in patients with anxiety disorders.

1 reference

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7 January 2021

Systemic uptake inhibition decreases serotonin release via somatodendritic autoreceptor activation

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7 January 2021

Effects of a selective 5-HT reuptake blocker, citalopram, on the sensitivity of 5-HT autoreceptors: electrophysiological studies in the rat brain

1 reference

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7 January 2021

Serotonin 5-HT1A autoreceptor blockade potentiates the ability of the 5-HT reuptake inhibitor citalopram to increase nerve terminal output of 5-HT in vivo: a microdialysis study.

1 reference

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7 January 2021

Interaction between a selective 5-HT1A receptor antagonist and an SSRI in vivo: effects on 5-HT cell firing and extracellular 5-HT

1 reference

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7 January 2021

Enhancement of fluoxetine-dependent increase of extracellular serotonin (5-HT) levels by (-)-pindolol, an antagonist at 5-HT1A receptors

1 reference

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7 January 2021

Effect of a selective 5-HT reuptake inhibitor in combination with 5-HT1A and 5-HT1B receptor antagonists on extracellular 5-HT in rat frontal cortex in vivo

1 reference

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7 January 2021

Pindolol Induces a Rapid Improvement of Depressed Patients Treated With Serotonin Reuptake Inhibitors

1 reference

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7 January 2021

Serotonergic autoreceptor blockade in the reduction of antidepressant latency: personality variables and response to paroxetine and pindolol.

1 reference

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7 January 2021

Randomised, double-blind, placebo-controlled trial of pindolol in combination with fluoxetine antidepressant treatment

1 reference

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7 January 2021

How long should pindolol be associated with paroxetine to improve the antidepressant response?

1 reference

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7 January 2021

Does the addition of pindolol accelerate or enhance the response to selective serotonin reuptake inhibitor antidepressants?

1 reference

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7 January 2021

A double-blind, randomized, placebo-controlled trial of pindolol augmentation in depressive patients resistant to serotonin reuptake inhibitors. Grup de Recerca en Trastorns Afectius.

1 reference

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7 January 2021

Third-generation antidepressants

1 reference

https://api.crossref.org/works/10.1016%2FS0014-827X%2800%2900050-1

7 January 2021

A new pharmophoric model for 5-HT reuptake-inhibitors: differentiation of amphetamine analogues

1 reference

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7 January 2021

Direct evidence for an important species difference in the mechanism of 8-OH-DPAT-induced hypothermia

1 reference

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7 January 2021

Characterization of [3H]paroxetine binding to rat cortical membranes.

1 reference

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7 January 2021

Molecular pharmacology of 5-HT1 and 5-HT2 recognition sites in rat and pig brain membranes: radioligand binding studies with [3H]5-HT, [3H]8-OH-DPAT, (-)[125I]iodocyanopindolol, [3H]mesulergine and [3H]ketanserin

1 reference

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7 January 2021

Serotonin-S2 receptor binding sites and functional correlates

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7 January 2021

[3H]-BRL 43694 (Granisetron), a specific ligand for 5-HT3 binding sites in rat brain cortical membranes

1 reference

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7 January 2021

Spiperone: a ligand of choice for neuroleptic receptors. 1. Kinetics and characteristics of in vitro binding

1 reference

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7 January 2021

N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline, an irreversible receptor inactivator, as a tool for measurement of alpha 2-adrenoceptor occupancy in vivo.

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7 January 2021

Depression: a new animal model sensitive to antidepressant treatments

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7 January 2021

5-HT3 receptor antagonists reverse helpless behaviour in rats

1 reference

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7 January 2021

Role of the serotonergic system in the forced swimming test

1 reference

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7 January 2021

Mediation of the antidepressant-like effect of 8-OH-DPAT in mice by postsynaptic 5-HT1A receptors

1 reference

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7 January 2021

Studies on the role of 5-HT1A autoreceptors and alpha 1-adrenoceptors in the inhibition of 5-HT release--I. BMY7378 and prazosin

1 reference

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7 January 2021

The role of 5-HT1A autoreceptors and alpha1-adrenoceptors in the modulation of 5-HT release--III. Clozapine and the novel putative antipsychotic S 16924.

1 reference

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7 January 2021

5-HT1A receptors in the median raphe nucleus and dorsal hippocampus may mediate anxiolytic and anxiogenic behaviours respectively.

1 reference

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7 January 2021

Identifiers

10.1016/S0014-827X(00)00050-1

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10983279%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10983279%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

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