(Q59281178)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23496221%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

title

CRAC inhibitors: identification and potential (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23496221%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23496221%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

Rainer Schindl

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23496221%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

Christoph Romanin

series ordinal

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23496221%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

author name string

Reinhard Fritsch

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23496221%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

language of work or name

English

0 references

publication date

1 July 2008

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23496221%20AND%20SRC:MED&resulttype=core&format=json

Expert Opinion on Drug Discovery

26 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23496221%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

volume

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23496221%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23496221%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

page(s)

787-800

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23496221%20AND%20SRC:MED&resulttype=core&format=json

Calcium signalling: dynamics, homeostasis and remodelling

26 February 2020

cites work

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Cracking the calcium entry code

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

21 January 2018

A CRAC current tango.

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Store-operated calcium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Calcium entry mediated by SOCs and TRP channels: variations and enigma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Mechanism of store-operated calcium entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Calcium signaling in non-excitable cells: Ca2+ release and influx are independent events linked to two plasma membrane Ca2+ entry channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

CRAC channels: activation, permeation, and the search for a molecular identity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Depletion of intracellular calcium stores activates a calcium current in mast cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Ca2+-independent phospholipase A2 is a novel determinant of store-operated Ca2+ entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Ion channels in the immune system as targets for immunosuppression

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Ion channels and lymphocyte activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

The multiple causes of human SCID

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Immunodeficiency is a tough nut to CRAC: the importance of calcium flux in T cell activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Severe combined immunodeficiency--molecular pathogenesis and diagnosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Gene therapy for severe combined immunodeficiencies

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Signalling to transcription: store-operated Ca2+ entry and NFAT activation in lymphocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Orai1 and STIM reconstitute store-operated calcium channel function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Amplification of CRAC current by STIM1 and CRACM1 (Orai1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Ca2+ influx pathways mediated by swelling or stores depletion in mouse thymocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Comparison of human TRPC3 channels in receptor-activated and store-operated modes. Differential sensitivity to channel blockers suggests fundamental differences in channel composition

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

SK&F 96365, a novel inhibitor of receptor-mediated calcium entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Inhibition by SK&F 96365 of Ca2+ current, IL-2 production and activation in T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Separation and characterization of currents through store-operated CRAC channels and Mg2+-inhibited cation (MIC) channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Identification of store-independent and store-operated Ca2+ conductances in Caenorhabditis elegans intestinal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Maitotoxin-elicited calcium influx in cultured cells. Effect of calcium-channel blockers

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Inhibitors of cytochrome P-450-dependent arachidonic acid metabolism.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Genetic evidence for involvement of type 1, type 2 and type 3 inositol 1,4,5-trisphosphate receptors in signal transduction through the B-cell antigen receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Requirement of the inositol trisphosphate receptor for activation of store-operated Ca2+ channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Activation of the store‐operated calcium current ICRAC can be dissociated from regulated exocytosis in rat basophilic leukaemia (RBL‐1) cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

An examination of the secretion-like coupling model for the activation of the Ca2+ release-activated Ca2+ current I(CRAC) in RBL-1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Role of the phospholipase C-inositol 1,4,5-trisphosphate pathway in calcium release-activated calcium current and capacitative calcium entry

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Assessment of the role of the inositol 1,4,5-trisphosphate receptor in the activation of transient receptor potential channels and store-operated Ca2+ entry channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Potentiation and inhibition of Ca(2+) release-activated Ca(2+) channels by 2-aminoethyldiphenyl borate (2-APB) occurs independently of IP(3) receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Calcium release from the Golgi apparatus and the endoplasmic reticulum in HeLa cells stably expressing targeted aequorin to these compartments

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

2-Aminoethoxydiphenyl borate inhibits phototransduction and blocks voltage-gated potassium channels in Limulus ventral photoreceptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Dissociation of the store-operated calcium current I(CRAC) and the Mg-nucleotide-regulated metal ion current MagNuM.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

2-aminoethoxydiphenyl borate activates and sensitizes the heat-gated ion channel TRPV3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Block of TRPC5 channels by 2-aminoethoxydiphenyl borate: a differential, extracellular and voltage-dependent effect

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

The inositol trisphosphate receptor antagonist 2-aminoethoxydiphenylborate (2-APB) blocks Ca2+ entry channels in human platelets: cautions for its use in studying Ca2+ influx.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

CaT1 and the calcium release-activated calcium channel manifest distinct pore properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Store depletion-activated CaT1 currents in rat basophilic leukemia mast cells are inhibited by 2-aminoethoxydiphenyl borate. Evidence for a regulatory component that controls activation of both CaT1 and CRAC (Ca(2+) release-activated Ca(2+) channel)

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Pharmacological modulation of monovalent cation currents through the epithelial Ca2+ channel ECaC1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

TRP channel activation by reversible covalent modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Requirement of a soluble intracellular factor for activation of transient receptor potential A1 by pungent chemicals: role of inorganic polyphosphates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

CaT1 contributes to the stores-operated calcium current in Jurkat T-lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Discrimination of intracellular calcium store subcompartments using TRPV1 (transient receptor potential channel, vanilloid subfamily member 1) release channel activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

K+ channels as targets for specific immunomodulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

A Pyrazole Derivative, YM-58483, Potently Inhibits Store-Operated Sustained Ca2+ Influx and IL-2 Production in T Lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Potent inhibition of Ca2+ release-activated Ca2+ channels and T-lymphocyte activation by the pyrazole derivative BTP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

A pyrazole derivative potently inhibits lymphocyte Ca2+ influx and cytokine production by facilitating transient receptor potential melastatin 4 channel activity.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

A functional link between store-operated and TRPC channels revealed by the 3,5-bis(trifluoromethyl)pyrazole derivative, BTP2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

YM-58483, a selective CRAC channel inhibitor, prevents antigen-induced airway eosinophilia and late phase asthmatic responses via Th2 cytokine inhibition in animal models

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Calcium-independent phospholipase A(2): structure and function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

A novel mechanism for the store-operated calcium influx pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

DNA-PK contributes to the phosphorylation of AIRE: importance in transcriptional activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Myosin light chain kinase regulates capacitative ca(2+) entry in human monocytes/macrophages

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Calcium signals mediated by STIM and Orai proteins--a new paradigm in inter-organelle communication

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

STIM1, an essential and conserved component of store-operated Ca2+ channel function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

STIM1 signalling controls store-operated calcium entry required for development and contractile function in skeletal muscle

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Gene regulation mediated by calcium signals in T lymphocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

STIM1 has a plasma membrane role in the activation of store-operated Ca(2+) channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Murine ORAI2 splice variants form functional Ca2+ release-activated Ca2+ (CRAC) channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Canonical transient receptor potential 5 channel in conjunction with Orai1 and STIM1 allows Sr2+ entry, optimal influx of Ca2+, and degranulation in a rat mast cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Two types of store-operated Ca2+ channels with different activation modes and molecular origin in LNCaP human prostate cancer epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Store-operated Ca2+ current in prostate cancer epithelial cells. Role of endogenous Ca2+ transporter type 1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

CaT1 knock-down strategies fail to affect CRAC channels in mucosal-type mast cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

CRACM1, CRACM2, and CRACM3 are store-operated Ca2+ channels with distinct functional properties.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

The long and arduous road to CRAC.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

STIM2 is a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

STIM2 protein mediates distinct store-dependent and store-independent modes of CRAC channel activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

STIM1 is a MT-plus-end-tracking protein involved in remodeling of the ER.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Coupling of STIM1 to store-operated Ca2+ entry through its constitutive and inducible movement in the endoplasmic reticulum

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Role of the microtubule cytoskeleton in the function of the store-operated Ca2+ channel activator STIM1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Stromal interaction molecule 1 (STIM1), a transmembrane protein with growth suppressor activity, contains an extracellular SAM domain modified by N-linked glycosylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

The elementary unit of store-operated Ca2+ entry: local activation of CRAC channels by STIM1 at ER-plasma membrane junctions

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Ca2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Ca2+-store-dependent and -independent reversal of Stim1 localization and function

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

New insights into the molecular mechanisms of store-operated Ca2+ signaling in T cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Energy transfer: a spectroscopic ruler

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

High-throughput screening assays for the identification of chemical probes

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

Live-cell imaging reveals sequential oligomerization and local plasma membrane targeting of stromal interaction molecule 1 after Ca2+ store depletion.

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

STIM1 carboxyl-terminus activates native SOC, I(crac) and TRPC1 channels

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F17460441.3.7.787

21 January 2018

Identifiers

DOI

10.1517/17460441.3.7.787

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23496221%20AND%20SRC:MED&resulttype=core&format=json

26 February 2020

1 reference