(Q59353126)

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De Novo Design of α-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery

scientific article published on 19 September 2018

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scholarly article

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21 April 2020

De Novo Design of α-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery (English)

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21 April 2020

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1

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21 April 2020

2

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21 April 2020

3

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21 April 2020

4

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11

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21 April 2020

12

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21 April 2020

13

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21 April 2020

author name string

Ruiyuan Cao

5

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21 April 2020

Guodong Liang

6

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21 April 2020

Yue Li

7

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21 April 2020

Guangpeng Meng

8

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21 April 2020

Weicong Wang

9

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21 April 2020

Weiguo Shi

10

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21 April 2020

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publication date

19 September 2018

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21 April 2020

Journal of Medicinal Chemistry

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21 April 2020

61

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21 April 2020

19

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21 April 2020

8734-8745

1 reference

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PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30192544%20AND%20SRC:MED&resulttype=core&format=json

21 April 2020

Peptides corresponding to a predictive alpha-helical domain of human immunodeficiency virus type 1 gp41 are potent inhibitors of virus infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of influenza haemagglutinin at the pH of membrane fusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIV-1 inhibition by a peptide

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A trimeric structural domain of the HIV-1 transmembrane glycoprotein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIV-1 membrane fusion mechanism: structural studies of the interactions between biologically-active peptides from gp41.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Surface salt bridges stabilize the GCN4 leucine zipper

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Short constrained peptides that inhibit HIV-1 entry

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structural biology of type I viral membrane fusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Virus entry: molecular mechanisms and biomedical applications

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alternative views of functional protein binding epitopes obtained by combinatorial shotgun scanning mutagenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Demonstrating the C-terminal boundary of the HIV 1 fusion conformation in a dynamic ongoing fusion process and implication for fusion inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design of helical, oligomeric HIV-1 fusion inhibitor peptides with potent activity against enfuvirtide-resistant virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Viral membrane fusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rationally designed anti-HIV peptides containing multifunctional domains as molecule probes for studying the mechanisms of action of the first and second generation HIV fusion inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Electrostatically constrained alpha-helical peptide inhibits replication of HIV-1 resistant to enfuvirtide

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-HIV drugs: 25 compounds approved within 25 years after the discovery of HIV.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Viral entry inhibitors targeted to the membrane site of action.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Management of HIV and hepatitis virus coinfection

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coiled coils: attractive protein folding motifs for the fabrication of self-assembled, responsive and bioactive materials

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of peptide and small-molecule HIV-1 fusion inhibitors that target gp41.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of Ebola virus entry by a C-peptide targeted to endosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Capturing a fusion intermediate of influenza hemagglutinin with a cholesterol-conjugated peptide, a new antiviral strategy for influenza virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amphipathic properties of HIV-1 gp41 fusion inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Interactions between different generation HIV-1 fusion inhibitors and the putative mechanism underlying the synergistic anti-HIV-1 effect resulting from their combination

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Design, synthesis, and biological evaluation of highly potent small molecule-peptide conjugates as new HIV-1 fusion inhibitors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A basis set of de novo coiled-coil peptide oligomers for rational protein design and synthetic biology

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure of the Fusion Core and Inhibition of Fusion by a Heptad Repeat Peptide Derived from the S Protein of Middle East Respiratory Syndrome Coronavirus

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Artificial peptides conjugated with cholesterol and pocket-specific small molecules potently inhibit infection by laboratory-adapted and primary HIV-1 isolates and enfuvirtide-resistant HIV-1 strains

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hydrophobic mutations in buried polar residues enhance HIV-1 gp41 N-terminal heptad repeat-C-terminal heptad repeat interactions and C-peptides' anti-HIV activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conjugation of a nonspecific antiviral sapogenin with a specific HIV fusion inhibitor: a promising strategy for discovering new antiviral therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of pentacyclic triterpenoids as potential entry inhibitors of influenza viruses

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Middle East respiratory syndrome coronavirus (MERS-CoV) entry inhibitors targeting spike protein.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Single-chain protein mimetics of the N-terminal heptad-repeat region of gp41 with potential as anti-HIV-1 drugs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Broad-spectrum antiviral agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective Effect of Intranasal Regimens Containing Peptidic Middle East Respiratory Syndrome Coronavirus Fusion Inhibitor Against MERS-CoV Infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of potent and long-acting HIV-1 fusion inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Intranasal application of polyethyleneimine suppresses influenza virus infection in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Current and novel antiviral strategies for influenza infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel HIV-1 gp41 tripartite model for rational design of HIV-1 fusion inhibitors with improved antiviral activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Novel Design of Heptad Amphiphiles To Enhance Cell Selectivity, Salt Resistance, Antibiofilm Properties and Their Membrane-Disruptive Mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-influenza A Virus Activity of Dendrobine and Its Mechanism of Action.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

HIV-1 gp41-targeting fusion inhibitory peptides enhance the gp120-targeting protein-mediated inactivation of HIV-1 virions

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enfuvirtide (T20)-Based Lipopeptide Is a Potent HIV-1 Cell Fusion Inhibitor: Implications for Viral Entry and Inhibition

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potent influenza A virus entry inhibitors targeting a conserved region of hemagglutinin

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipidation increases antiviral activities of coronavirus fusion-inhibiting peptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potent peptidic fusion inhibitors of influenza virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discovery of Hydrocarbon-Stapled Short α-Helical Peptides as Promising Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Fusion Inhibitors.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Favipiravir (T-705) protects against Nipah virus infection in the hamster model.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An effective strategy for recapitulating N-terminal heptad repeat trimers in enveloped virus surface glycoproteins for therapeutic applications.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

De novo design of isopeptide bond-tethered triple-stranded coiled coils with exceptional resistance to unfolding and proteolysis: implication for developing antiviral therapeutics

1 reference

https://pubmed.ncbi.nlm.nih.gov/30192544

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/ACS.JMEDCHEM.8B00890

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30192544%20AND%20SRC:MED&resulttype=core&format=json

21 April 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30192544%20AND%20SRC:MED&resulttype=core&format=json

21 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30192544%20AND%20SRC:MED&resulttype=core&format=json

21 April 2020

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