(Q59525088)

English

A dispersion model of hepatic elimination: 2. Steady-state considerations-influence of hepatic blood flow, binding within blood, and hepatocellular enzyme activity

scientific article published on 01 June 1986

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3783447%20AND%20SRC:MED&resulttype=core&format=json

4 October 2019

A dispersion model of hepatic elimination: 2. Steady-state considerations--influence of hepatic blood flow, binding within blood, and hepatocellular enzyme activity (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3783447%20AND%20SRC:MED&resulttype=core&format=json

4 October 2019

Michael S. Roberts

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3783447%20AND%20SRC:MED&resulttype=core&format=json

4 October 2019

author name string

M Rowland

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3783447%20AND%20SRC:MED&resulttype=core&format=json

4 October 2019

publication date

1 June 1986

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3783447%20AND%20SRC:MED&resulttype=core&format=json

4 October 2019

number of pages

28

1 reference

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inferred from page(s)

Journal of Pharmacokinetics and Pharmacodynamics

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3783447%20AND%20SRC:MED&resulttype=core&format=json

4 October 2019

14

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3783447%20AND%20SRC:MED&resulttype=core&format=json

4 October 2019

3

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3783447%20AND%20SRC:MED&resulttype=core&format=json

4 October 2019

261-288

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3783447%20AND%20SRC:MED&resulttype=core&format=json

4 October 2019

https://scigraph.springernature.com/pub.10.1007/bf01106707

0 references

Flow dependence of first-order uptake of substances by heterogeneous perfused organs

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Models of hepatic drug clearance: discrimination between the ‘well stirred’ and ‘parallel-tube’ models

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Factors regulating drug metabolism in intact hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Curve fitting and modeling in pharmacokinetics and some practical experiences with NONLIN and a new program FUNFIT

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein binding and hepatic clearance: discrimination between models of hepatic clearance with diazepam, a drug of high intrinsic clearance, in the isolated perfused rat liver preparation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of unbound drug concentration in blood to discriminate between two models of hepatic drug elimination

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A dispersion model of hepatic elimination: 1. Formulation of the model and bolus considerations.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Albumin binding and hepatic uptake: the importance of model selection

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of hepatic blood flow on the hepatic removal rate of oxyphenbutazone in the dog

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional implications of liver cell heterogeneity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic extraction of free fatty acids in pregnant and nonpregnant female rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of sinusoidal perfusion on galactose elimination kinetics in perfused rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Circulatory transport of iodoantipyrine and water in the isolated dog heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Uptake of Taurocholic Acid into Isolated Rat-Liver Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic clearance of drugs. II. Experimental evidence for acceptance of the “well-stirred” model over the “parallel tube” model using lidocaine in the perfused rat liverin situ preparation

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the uptake of materials by the intact liver. The transport and net removal of galactose

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of albumin on bile acid uptake by isolated rat hepatocytes. Is there a common bile acid carrier?

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transport of fluorescent compounds into hepatocytes and the resultant zonal labeling of the hepatic acinus in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative morphology of the sinusoids of the hepatic acinus. Quantimet analysis of rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The action in the perfused liver of acetylcholine, sympathomimetic substances and local anaesthetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

How small is the functional variability of liver sinusoids?

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic elimination of flowing substrates: the distributed model

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Albumin does not mediate the removal of taurocholate by the rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic drug clearance model: comparison among the distributed, parallel-tube and well-stirred models

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetic interpretation of hepatic multiple-indicator dilution studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The metabolism of drugs in isolated rat hepatocytes. A comparison with in vivo drug metabolism and drug metabolism in subcellular liver fractions

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Albumin helps mediate removal of taurocholate by rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic uptake of albumin-bound substances: albumin receptor concept

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional and anatomic heterogeneity in the liver acinus: impact on transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Commentary: a physiological approach to hepatic drug clearance

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of models for determining intestinal wall permeabilities

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta 2-Adrenoceptors in rat liver microcirculation

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flow dependence of propranolol elimination in perfused rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A linear method for determining liver sinusoidal and extravascular volumes

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analyzing tracer disappearance curves to study hepatic transport kinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autoradiographic evidence for hepatic lobular concentration gradient of bile acid derivative.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of hepatic extraction ratio from in vitro measurement of intrinsic clearance

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The terminal hepatic microcirculation in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Circulatory pathways in the rat liver as revealed by P32 chromic phosphate colloid uptake in the isolated perfused liver preparation

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liver blood flow. II. Effects of drugs and hormones on liver blood flow

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The metabolism of phenytoin by isolated hepatocytes and hepatic microsomes from male rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Uptake of bile acids by isolated rat hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic transport kinetics and plasma disappearance curves: distributed modeling versus conventional approach

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Saturation kinetics in hepatic drug removal: a statistical approach to functional heterogeneity

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discrimination between the venous equilibrium and sinusoidal models of hepatic drug elimination in the isolated perfused rat liver by perturbation of propranolol protein binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Diffusion layer effects on permeation of phenylbutazone through polydimethylsiloxane

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic uptake of propranolol.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3783447

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF01106707

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3783447%20AND%20SRC:MED&resulttype=core&format=json

4 October 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3783447%20AND%20SRC:MED&resulttype=core&format=json

4 October 2019

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