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Squalene synthase: Structure and regulation
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scholarly article
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title
Squalene synthase: Structure and regulation
(English)
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main subject
squalene
1 reference
based on heuristic
inferred from title
author name string
Terese R. Tansey
series ordinal
1
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Ishaiahu Shechter
series ordinal
2
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publication date
2000
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published in
Progress in Molecular Biology and Translational Science
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page(s)
157-195
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cites work
Bile acid biosynthesis
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Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain
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Cholesterol modification of hedgehog signaling proteins in animal development
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7 January 2021
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Cholesterol metabolism and embryogenesis
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7 January 2021
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Physical-Chemical Basis of Lipid Deposition in Atherosclerosis
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Teratogen-mediated inhibition of target tissue response to Shh signaling.
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7 January 2021
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Regulation of the mevalonate pathway
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7 January 2021
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Biosynthesis of non-head-to-tail terpenes. Formation of 1'-1 and 1'-3 linkages
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Polyisoprenyl phosphates in intracellular signalling.
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7 January 2021
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Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alpha
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7 January 2021
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Orphan nuclear receptors: shifting endocrinology into reverse
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7 January 2021
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Discovery, biosynthesis, and mechanism of action of the zaragozic acids: potent inhibitors of squalene synthase
1 reference
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Crossref
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7 January 2021
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3-(4-chlorophenyl)-2-(4-diethylaminoethoxyphenyl)-A-pentenonitrile monohydrogen citrate and related analogs. Reversible, competitive, first half-reaction squalene synthetase inhibitors
1 reference
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Crossref
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7 January 2021
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An enzyme-bound intermediate in the conversion of farnesyl pyrophosphate to squalene
1 reference
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Studies on the mechanism of squalene biosynthesis. Presqualene pyrophosphate, stereochemistry and a mechanism for its conversion to squalene
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Stereoselective total synthesis of (+-)-presqualene alcohol
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
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7 January 2021
based on heuristic
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Synthesis and conversion of presqualene alcohol to squalene
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanism of presqualene pyrophosphate-squalene biosynthesis
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Purification to homogeneity and some properties of squalene synthetase
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Physiological implications of sterol biosynthesis in yeast
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of squalene synthetase and squalene epoxidase activities in Saccharomyces cerevisiae
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Isolation and primary structure of the ERG9 gene of Saccharomyces cerevisiae encoding squalene synthetase
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Conservation between human and fungal squalene synthetases: similarities in structure, function, and regulation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cloning, expression and characterisation of the cDNA encoding human hepatic squalene synthase, and its relationship to phytoene synthase
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Analysis and purification of phosphorylated isoprenoids by reversed-phase HPLC
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Overexpression, purification, and kinetic characterization of a carboxyl-terminal-truncated yeast squalene synthetase.
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Expression, purification, and characterization of the human squalene synthase: use of yeast and baculoviral systems
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Truncation of human squalene synthase yields active, crystallizable protein
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Function-structure studies and identification of three enzyme domains involved in the catalytic activity in rat hepatic squalene synthase
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cell compartmentalization of cholesterol biosynthesis
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Crossref
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7 January 2021
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Subcellular localization of squalene synthase in human hepatoma cell line Hep G2
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Squalene synthetase
1 reference
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Crossref
reference URL
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7 January 2021
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The mechanism of the condensation reactions of cholesterol biosynthesis. Fourth Morton lecture.
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Biosynthesis of Squalene. Evidence for a Tertiary Cyclopropylcarbinyl Cationic Intermediate in the Rearrangement of Presqualene Diphosphate to Squalene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Crystal structure of recombinant farnesyl diphosphate synthase at 2.6-A resolution
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Crystal structure of pentalenene synthase: mechanistic insights on terpenoid cyclization reactions in biology
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Structural basis for cyclic terpene biosynthesis by tobacco 5-epi-aristolochene synthase
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Chain elongation in the isoprenoid biosynthetic pathway.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Creating isoprenoid diversity
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Carotenoids 2: Genetics and molecular biology of carotenoid pigment biosynthesis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Enzymatic synthesis of phytoene.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular cloning and expression in Escherichia coli of a cyanobacterial gene coding for phytoene synthase, a carotenoid biosynthesis enzyme.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Multiple determinants direct the orientation of signal-anchor proteins: the topogenic role of the hydrophobic signal domain
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Signal sequences: more than just greasy peptides
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
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7 January 2021
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inferred from DOI database lookup
Cloning and characterization of the Arabidopsis thaliana SQS1 gene encoding squalene synthase--involvement of the C-terminal region of the enzyme in the channeling of squalene through the sterol pathway
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Structure and function of a squalene cyclase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
The structure of the membrane protein squalene-hopene cyclase at 2.0 A resolution
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cation-pi interactions in chemistry and biology: a new view of benzene, Phe, Tyr, and Trp
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
The Cationminus signpi Interaction
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular cloning and functional expression of a cDNA for mouse squalene synthase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Localization of the squalene synthase gene (FDFT1) to human chromosome 8p22-p23.1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Embryonic lethality and defective neural tube closure in mice lacking squalene synthase.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular characterization of tobacco squalene synthase and regulation in response to fungal elicitor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification and regulation of rat squalene synthetase mRNA
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Studies on the site of the feedback control of cholesterol synthesis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Proceedings of the Biochemical Society
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
beta-Hydroxy-beta-methyl-glutaryl coenzyme A reductase, cleavage and condensing enzymes in relation to cholesterol formation in rat liver
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of 3-hydroxy-3-methylglutarate and mevalonate biosynthesis by rat liver homogenates. Effects of fasting, cholesterol feeding, and triton administration
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of squalene synthetase activity in rat liver: elevation by cholestyramine, but no diurnal variation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of squalene synthetase in human hepatoma cell line Hep G2 by sterols, and not by mevalonate-derived non-sterols
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Sterol regulatory element-binding proteins: activators of cholesterol and fatty acid biosynthesis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of conserved cis-elements and transcription factors required for sterol-regulated transcription of stearoyl-CoA desaturase 1 and 2
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cooperation by sterol regulatory element-binding protein and Sp1 in sterol regulation of low density lipoprotein receptor gene
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Sterol regulation of 3-hydroxy-3-methylglutaryl-coenzyme A synthase gene through a direct interaction between sterol regulatory element binding protein and the trimeric CCAAT-binding factor/nuclear factor Y.
1 reference
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Crossref
reference URL
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7 January 2021
based on heuristic
inferred from DOI database lookup
Signaling molecules derived from the cholesterol biosynthetic pathway: mechanisms of action and possible roles in human disease
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Synergistic binding of sterol regulatory element-binding protein and NF-Y to the farnesyl diphosphate synthase promoter is critical for sterol-regulated expression of the gene
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
NF-Y has a novel role in sterol-dependent transcription of two cholesterogenic genes
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A critical role for cAMP response element-binding protein (CREB) as a Co-activator in sterol-regulated transcription of 3-hydroxy-3-methylglutaryl coenzyme A synthase promoter
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
YY1 is a negative regulator of transcription of three sterol regulatory element-binding protein-responsive genes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Co-stimulation of promoter for low density lipoprotein receptor gene by sterol regulatory element-binding protein and Sp1 is specifically disrupted by the yin yang 1 protein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Molecular cloning and functional analysis of the promoter of the human squalene synthase gene
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Multiple sequence elements are involved in the transcriptional regulation of the human squalene synthase gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Multiple DNA elements for sterol regulatory element-binding protein and NF-Y are responsible for sterol-regulated transcription of the genes for human 3-hydroxy-3-methylglutaryl coenzyme A synthase and squalene synthase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
DNA Binding Specificity of the CCAAT-binding Factor CBF/NF-Y
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential transcriptional regulation of the human squalene synthase gene by sterol regulatory element-binding proteins (SREBP) 1a and 2 and involvement of 5' DNA sequence elements in the regulation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The physiological role of sterol regulatory element-binding protein-2 in cultured human cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Differential stimulation of cholesterol and unsaturated fatty acid biosynthesis in cells expressing individual nuclear sterol regulatory element-binding proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of endotoxin and cytokines on lipid metabolism.
1 reference
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Crossref
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https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
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7 January 2021
based on heuristic
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A phase I trial of intravenously-administered recombinant tumor necrosis factor-alpha in cancer patients
1 reference
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https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
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7 January 2021
based on heuristic
inferred from DOI database lookup
Effect of interleukin-1 alpha on lipoprotein lipids in cynomolgus monkeys: comparison to tumor necrosis factor
1 reference
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7 January 2021
based on heuristic
inferred from DOI database lookup
Transforming growth factor-beta 1 and interleukin-1 beta stimulate LDL receptor activity in Hep G2 cells
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0079-6603%2800%2965005-5
retrieved
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Tumor necrosis factor-alpha stimulates hepatic lipogenesis in the rat in vivo
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A uniform alteration in serum lipid metabolism occurring during inflammation in mice
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Tumor necrosis factor up-regulates expression of low-density lipoprotein receptors on HepG2 cells
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Differential roles of extracellular signal-regulated kinase-1/2 and p38(MAPK) in interleukin-1beta- and tumor necrosis factor-alpha-induced low density lipoprotein receptor expression in HepG2 cells
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NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses
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Squalene synthase inhibitors: their potential as hypocholesterolaemic agents.
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Ertosterol biosynthesis in Saccharomyces cerevisiae: mutants deficient in the early steps of the pathway
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10.1016/S0079-6603(00)65005-5
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