(Q60301878)

English

Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase

scientific article published on 01 February 2000

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scholarly article

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Europe PubMed Central

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3 November 2019

Novel octaketide macrolides related to 6-deoxyerythronolide B provide evidence for iterative operation of the erythromycin polyketide synthase (English)

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3 November 2019

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Michael J Dawson

8

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3 November 2019

14

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3 November 2019

author name string

B Wilkinson

1

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3 November 2019

G Foster

2

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3 November 2019

B A Rudd

3

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3 November 2019

N L Taylor

4

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3 November 2019

A P Blackaby

5

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3 November 2019

P J Sidebottom

6

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3 November 2019

D J Cooper

7

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3 November 2019

A D Buss

9

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3 November 2019

S Gaisser

10

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3 November 2019

I U Böhm

11

1 reference

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3 November 2019

C J Rowe

12

1 reference

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3 November 2019

J Cortés

13

1 reference

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3 November 2019

J Staunton

15

1 reference

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3 November 2019

publication date

1 February 2000

1 reference

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3 November 2019

Chemistry and Biology

1 reference

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PubMed publication ID

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3 November 2019

7

1 reference

Europe PubMed Central

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3 November 2019

2

1 reference

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3 November 2019

111-117

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10662692%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

Fatty acid synthase, a proficient multifunctional enzyme

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Escherichia coli as a model for the regulation of dissociable (type II) fatty acid biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900076-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular genetics of polyketides and its comparison to fatty acid biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900076-4

7 January 2021

based on heuristic

inferred from DOI database lookup

[Biosynthesis of 6-methylsalicylic acid]

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900076-4

7 January 2021

based on heuristic

inferred from DOI database lookup

An unusually large multifunctional polypeptide in the erythromycin-producing polyketide synthase of Saccharopolyspora erythraea

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900076-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Modular organization of genes required for complex polyketide biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900076-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Polyketide synthesis in vitro on a modular polyketide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900076-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification of DEBS 1, DEBS 2 and DEBS 3, the multienzyme polypeptides of the erythromycin-producing polyketide synthase from Saccharopolyspora erythraea

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900076-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Identification and characterization of the niddamycin polyketide synthase genes from Streptomyces caelestis

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900076-4

7 January 2021

based on heuristic

inferred from DOI database lookup

The biosynthetic gene cluster for the polyketide immunosuppressant rapamycin

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900076-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Organization of the biosynthetic gene cluster for rapamycin in Streptomyces hygroscopicus: analysis of the enzymatic domains in the modular polyketide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900076-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Enzymatic characterisation of the multifunctional enzyme delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Streptomyces clavuligerus

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900076-4

7 January 2021

based on heuristic

inferred from DOI database lookup

A gene cluster for macrolide antibiotic biosynthesis in Streptomyces venezuelae: architecture of metabolic diversity

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900076-4

7 January 2021

based on heuristic

inferred from DOI database lookup

A Sorangium cellulosum (myxobacterium) gene cluster for the biosynthesis of the macrolide antibiotic soraphen A: cloning, characterization, and homology to polyketide synthase genes from actinomycetes

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900076-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Correlation of the avermectin polyketide synthase genes to the avermectin structure. Implications for designing novel avermectins.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900076-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Cloning and sequence analysis of the putative rifamycin polyketide synthase gene cluster from Amycolatopsis mediterranei

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900076-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterisation of a Streptomyces antibioticus gene encoding a type I polyketide synthase which has an unusual coding sequence

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900076-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Biosynthesis of the ansamycin antibiotic rifamycin: deductions from the molecular analysis of the rif biosynthetic gene cluster of Amycolatopsis mediterranei S699.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900076-4

7 January 2021

based on heuristic

inferred from DOI database lookup

The biosynthetic gene cluster for the 26-membered ring polyene macrolide pimaricin. A new polyketide synthase organization encoded by two subclusters separated by functionalization genes.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900076-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Modular Peptide Synthetases Involved in Nonribosomal Peptide Synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900076-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Biosynthesis of Erythromycin and Rapamycin.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900076-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Engineering of a minimal modular polyketide synthase, and targeted alteration of the stereospecificity of polyketide chain extension

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900076-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Repositioning of a domain in a modular polyketide synthase to promote specific chain cleavage

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900076-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Engineered Biosynthesis of Structurally Diverse Tetraketides by a Trimodular Polyketide Synthase

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900076-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Engineered intermodular and intramodular polyketide synthase fusions

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900076-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Knowledge-based design of bimodular and trimodular polyketide synthases based on domain and module swaps: a route to simple statin analogues

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900076-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Manipulation of Modular Polyketide Synthases.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900076-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Harnessing the Biosynthetic Potential of Modular Polyketide Synthases

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900076-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Combinatorial approaches to polyketide biosynthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900076-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Combinatorial biosynthesis of erythromycin and complex polyketides

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900076-4

7 January 2021

based on heuristic

inferred from DOI database lookup

Construction of new vectors for high-level expression in actinomycetes.

1 reference

https://api.crossref.org/works/10.1016%2FS1074-5521%2800%2900076-4

7 January 2021

based on heuristic

inferred from DOI database lookup

A mutant generated by expression of an engineered DEBS 1 protein from the erythromycin-producing polyketide synthase (PKS) in Streptomyces coelicolor produces the triketide as a lactone, but the major product is the nor-analogue derived from acetate

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Precursor-directed biosynthesis of erythromycin analogs by an engineered polyketide synthase

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence for a double-helical structure for modular polyketide synthases.

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence for two catalytically independent clusters of active sites in a functional modular polyketide synthase

1 reference

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based on heuristic

inferred from DOI database lookup

Functional orientation of the acyltransferase domain in a module of the erythromycin polyketide synthase

1 reference

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Modulation of Polyketide Synthase Activity by Accessory Proteins During Lovastatin Biosynthesis

1 reference

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Direct evidence that the rifamycin polyketide synthase assembles polyketide chains processively.

1 reference

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inferred from DOI database lookup

Identifiers

10.1016/S1074-5521(00)00076-4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10662692%20AND%20SRC:MED&resulttype=core&format=json

3 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

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3 November 2019

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