(Q60486806)

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30 December 2019

title

Genetic variation at the CYP2C locus and its association with torsemide biotransformation (English)

1 reference

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30 December 2019

1 reference

S V Vormfelde

1

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30 December 2019

M Schirmer

2

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30 December 2019

M R Toliat

3

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30 December 2019

I Meineke

4

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30 December 2019

J Kirchheiner

5

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30 December 2019

P Nürnberg

6

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30 December 2019

J Brockmöller

7

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30 December 2019

publication date

12 September 2006

1 reference

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The Pharmacogenomics Journal

30 December 2019

published in

1 reference

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30 December 2019

volume

7

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30 December 2019

issue

3

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30 December 2019

page(s)

200-211

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https://scigraph.springernature.com/pub.10.1038/sj.tpj.6500410

30 December 2019

exact match

0 references

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CYP2C19 polymorphism and proton pump inhibitors

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Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response

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P450 2C18 catalyzes the metabolic bioactivation of phenytoin.

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Functional characterization of novel allelic variants of CYP2C9 recently discovered in southeast Asians

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7 January 2021

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CYP2C9 haplotype structure in European American warfarin patients and association with clinical outcomes

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7 January 2021

5'-Flanking region polymorphisms of CYP2C9 and their relationship to S-warfarin metabolism in white and Japanese patients

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7 January 2021

Genetic polymorphisms and functional characterization of the 5'-flanking region of the human CYP2C9 gene: in vitro and in vivo studies

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7 January 2021

Detecting recent positive selection in the human genome from haplotype structure

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7 January 2021

Searching for signals of evolutionary selection in 168 genes related to immune function.

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7 January 2021

Genetic signature consistent with selection against the CYP3A4*1B allele in non-African populations

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7 January 2021

Torsemide metabolism by CYP2C9 variants and other human CYP2C subfamily enzymes

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7 January 2021

CYP2C9 polymorphisms and the interindividual variability in pharmacokinetics and pharmacodynamics of the loop diuretic drug torsemide

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7 January 2021

Differential contribution of active site residues in substrate recognition sites 1 and 5 to cytochrome P450 2C8 substrate selectivity and regioselectivity

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7 January 2021

Impact of CYP2C9 and CYP2C19 polymorphisms on tolbutamide kinetics and the insulin and glucose response in healthy volunteers

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7 January 2021

Effect of VKORC1 haplotypes on transcriptional regulation and warfarin dose

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7 January 2021

Effects of oral vitamin K on S- and R-warfarin pharmacokinetics and pharmacodynamics: enhanced safety of warfarin as a CYP2C9 probe

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7 January 2021

Intra-individual variability in urinary losartan oxidation ratio, an in vivo marker of CYP2C9 activity

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7 January 2021

Mephenytoin hydroxylation deficiency in Caucasians: frequency of a new oxidative drug metabolism polymorphism

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7 January 2021

Preliminary phenotypic map of chromosome 4p16 based on 4p deletions.

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7 January 2021

A single-nucleotide polymorphism tagging set for human drug metabolism and transport

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7 January 2021

Haplotype block structure of the cytochrome P450 CYP2C gene cluster on chromosome 10

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7 January 2021

The International HapMap Project

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7 January 2021

The R144C change in the CYP2C9*2 allele alters interaction of the cytochrome P450 with NADPH:cytochrome P450 oxidoreductase

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7 January 2021

Electrochemical characterisation of the human cytochrome P450 CYP2C9.

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7 January 2021

Linkage between the CYP2C8 and CYP2C9 genetic polymorphisms

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7 January 2021

Effect of aprepitant on the pharmacokinetics and pharmacodynamics of warfarin

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7 January 2021

Use of tolbutamide as a substrate probe for human hepatic cytochrome P450 2C9

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7 January 2021

Influence of CYP2C9 and CYP2C19 genetic polymorphisms on warfarin maintenance dose and metabolic clearance.

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7 January 2021

Single-point sampling for assessment of constitutive, induced, and inhibited cytochrome P450 3A activity with alfentanil or midazolam

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7 January 2021

Haploview: analysis and visualization of LD and haplotype maps

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7 January 2021

Characterisation of the genomic architecture of human chromosome 17q and evaluation of different methods for haplotype block definition

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7 January 2021

The effect of haplotype-block definitions on inference of haplotype-block structure and htSNPs selection.

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7 January 2021

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7 January 2021

A New Statistical Method for Haplotype Reconstruction from Population Data

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7 January 2021

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7 January 2021

Improved solid-phase extraction and HPLC measurement of torasemide and its important metabolites

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7 January 2021

Some suggestions for measuring predictive performance

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7 January 2021

Identifiers

DOI

10.1038/SJ.TPJ.6500410

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16969365%20AND%20SRC:MED&resulttype=core&format=json

30 December 2019

1 reference