(Q60617037)

English

IGHV unmutated CLL B cells are more prone to spontaneous apoptosis and subject to environmental prosurvival signals than mutated CLL B cells

scientific article published on 04 March 2011

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scholarly article

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24 January 2020

IGHV unmutated CLL B cells are more prone to spontaneous apoptosis and subject to environmental prosurvival signals than mutated CLL B cells (English)

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24 January 2020

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Barbara Castella

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Valentina Griggio

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24 January 2020

Massimo Massaia

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author name string

F Pantaleoni

2

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24 January 2020

M Rigoni

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24 January 2020

S Peola

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24 January 2020

M Foglietta

8

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24 January 2020

A Bosia

12

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24 January 2020

M Boccadoro

13

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publication date

4 March 2011

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24 January 2020

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24 January 2020

25

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24 January 2020

5

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24 January 2020

828-837

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24 January 2020

https://scigraph.springernature.com/pub.10.1038/leu.2011.12

0 references

Microenvironmental influences in chronic lymphocytic leukaemia: the role of antigen stimulation

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Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro

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CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment

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Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance

1 reference

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Distinctive features of "nurselike" cells that differentiate in the context of chronic lymphocytic leukemia

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The microenvironment in mature B-cell malignancies: a target for new treatment strategies

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Activated T cells induce expression of B7/BB1 on normal or leukemic B cells through a CD40-dependent signal

1 reference

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Role of BAFF and APRIL in human B-cell chronic lymphocytic leukaemia.

1 reference

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Cytokine modulation of nuclear factor-kappaB activity in B-chronic lymphocytic leukemia.

1 reference

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Rel a is an independent biomarker of clinical outcome in chronic lymphocytic leukemia.

1 reference

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Modulation of NF-kappa B activity and apoptosis in chronic lymphocytic leukemia B cells

1 reference

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7 January 2021

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Bodyguards and assassins: Bcl-2 family proteins and apoptosis control in chronic lymphocytic leukaemia.

1 reference

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Telomere length identifies two different prognostic subgroups among VH-unmutated B-cell chronic lymphocytic leukemia patients

1 reference

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Increased sensitivity of T lymphocytes to tumor necrosis factor receptor 1 (TNFR1)- and TNFR2-mediated apoptosis in HIV infection: relation to expression of Bcl-2 and active caspase-8 and caspase-3

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Statins revert doxorubicin resistance via nitric oxide in malignant mesothelioma.

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Secretion of cytokines and chemokines by polarized human epithelial cells from the female reproductive tract.

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Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells.

1 reference

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The NF-kappaB subunit Rel A is associated with in vitro survival and clinical disease progression in chronic lymphocytic leukemia and represents a promising therapeutic target

1 reference

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The two NF-kappaB activation pathways and their role in innate and adaptive immunity

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Regulation and function of NF-kappaB transcription factors in the immune system

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Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

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RelB is required for Peyer's patch development: differential regulation of p52-RelB by lymphotoxin and TNF

1 reference

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CD40 regulates the processing of NF-kappaB2 p100 to p52

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BAFF-induced NEMO-independent processing of NF-kappa B2 in maturing B cells.

1 reference

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Interleukin 4 protects chronic lymphocytic leukemic B cells from death by apoptosis and upregulates Bcl-2 expression

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CD38 and ZAP-70 are functionally linked and mark CLL cells with high migratory potential

1 reference

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Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells.

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Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1alpha

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Chronic lymphocytic leukemia

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Significantly shorter telomeres in T-cells of patients with ZAP-70+/CD38+ chronic lymphocytic leukaemia.

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Interleukin-8 induces nuclear transcription factor-kappaB through a TRAF6-dependent pathway

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Identifiers

10.1038/LEU.2011.12

1 reference

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24 January 2020

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