(Q60672438)

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Synthesis and biological activities of chaetocin and its derivatives

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Synthesis and biological activities of chaetocin and its derivatives (English)

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author name string

Mikiko Sodeoka

series ordinal

1

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Kosuke Dodo

series ordinal

2

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Yuou Teng

series ordinal

3

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Katsuya Iuchi

series ordinal

4

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Yoshitaka Hamashima

series ordinal

5

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Eriko Iwasa

series ordinal

6

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Shinya Fujishiro

series ordinal

7

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publication date

2 April 2012

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published in

Pure and Applied Chemistry

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volume

84

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issue

6

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page(s)

1369-1378

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cites work

Construction of epidithiodioxopiperazines by directed oxidation of hydroxyproline-derived dioxopiperazines

1 reference

20 August 2023

https://opencitations.net/index/coci/api/v1/references/10.1351/PAC-CON-11-10-31

Structure-activity relationship of N-methyl-bisindolylmaleimide derivatives as cell death inhibitors

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20 August 2023

https://opencitations.net/index/coci/api/v1/references/10.1351/PAC-CON-11-10-31

Inhibition of hydrogen peroxide-induced necrotic cell death with 3-amino-2-indolylmaleimide derivatives

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20 August 2023

https://opencitations.net/index/coci/api/v1/references/10.1351/PAC-CON-11-10-31

Discovery of gliotoxin as a new small molecule targeting thioredoxin redox system.

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20 August 2023

https://opencitations.net/index/coci/api/v1/references/10.1351/PAC-CON-11-10-31

Apoptosis-based therapies and drug targets

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20 August 2023

https://opencitations.net/index/coci/api/v1/references/10.1351/PAC-CON-11-10-31

A total synthesis of gliotoxin

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20 August 2023

https://opencitations.net/index/coci/api/v1/references/10.1351/PAC-CON-11-10-31

Chaetocin: a promising new antimyeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress

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20 August 2023

https://opencitations.net/index/coci/api/v1/references/10.1351/PAC-CON-11-10-31

Gliotoxin inactivates alcohol dehydrogenase by either covalent modification or free radical damage mediated by redox cycling.

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20 August 2023

https://opencitations.net/index/coci/api/v1/references/10.1351/PAC-CON-11-10-31

Activation of ASK-1 and downstream MAP kinases in cytochrome P4502E1 potentiated tumor necrosis factor alpha liver injury

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20 August 2023

https://opencitations.net/index/coci/api/v1/references/10.1351/PAC-CON-11-10-31

Total synthesis of (+)-11,11'-dideoxyverticillin A

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20 August 2023

https://opencitations.net/index/coci/api/v1/references/10.1351/PAC-CON-11-10-31

[Isolation and configuration of Chaetocin]

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20 August 2023

https://opencitations.net/index/coci/api/v1/references/10.1351/PAC-CON-11-10-31

The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover

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20 August 2023

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General approach to epipolythiodiketopiperazine alkaloids: total synthesis of (+)-chaetocins A and C and (+)-12,12'-dideoxychetracin A

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Studies on the mechanism of toxicity of the mycotoxin, sporidesmin. I. Generation of superoxide radical by sporidesmin

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20 August 2023

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The anticancer agent chaetocin is a competitive substrate and inhibitor of thioredoxin reductase

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20 August 2023

https://opencitations.net/index/coci/api/v1/references/10.1351/PAC-CON-11-10-31

A novel redox mechanism for the glutathione-dependent reversible uptake of a fungal toxin in cells

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Enantioselective total synthesis of (+)-gliocladine C: convergent construction of cyclotryptamine-fused polyoxopiperazines and a general approach for preparing epidithiodioxopiperazines from trioxopiperazine precursors.

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Unnatural enantiomer of chaetocin shows strong apoptosis-inducing activity through caspase-8/caspase-3 activation.

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20 August 2023

https://opencitations.net/index/coci/api/v1/references/10.1351/PAC-CON-11-10-31

Downregulation of histone H3 lysine 9 methyltransferase G9a induces centrosome disruption and chromosome instability in cancer cells.

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Initiator caspases in apoptosis signaling pathways

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Chromatin modifications and their function

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The epipolythiodioxopiperazine (ETP) class of fungal toxins: distribution, mode of action, functions and biosynthesis

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20 August 2023

https://opencitations.net/index/coci/api/v1/references/10.1351/PAC-CON-11-10-31

Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9.

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https://opencitations.net/index/coci/api/v1/references/10.1351/PAC-CON-11-10-31

Inactivation of rabbit muscle creatine kinase by reversible formation of an internal disulfide bond induced by the fungal toxin gliotoxin

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20 August 2023

https://opencitations.net/index/coci/api/v1/references/10.1351/PAC-CON-11-10-31

Total syntheses of chaetocin and ent-chaetocin

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20 August 2023

https://opencitations.net/index/coci/api/v1/references/10.1351/PAC-CON-11-10-31

The chemistry and biology of the immunomodulating agent gliotoxin and related epipolythiodioxopiperazines

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20 August 2023

https://opencitations.net/index/coci/api/v1/references/10.1351/PAC-CON-11-10-31

Remodeling of nuclear architecture by the thiodioxoxpiperazine metabolite chaetocin

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20 August 2023

https://opencitations.net/index/coci/api/v1/references/10.1351/PAC-CON-11-10-31

A Three-Step Entry to the Aspirochlorine Family of Antifungal Agents

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20 August 2023

https://opencitations.net/index/coci/api/v1/references/10.1351/PAC-CON-11-10-31

Total synthesis of epicoccin G.

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20 August 2023

https://opencitations.net/index/coci/api/v1/references/10.1351/PAC-CON-11-10-31

Total synthesis of (+)-chaetocin and its analogues: their histone methyltransferase G9a inhibitory activity

1 reference

20 August 2023

https://opencitations.net/index/coci/api/v1/references/10.1351/PAC-CON-11-10-31

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10.1351/PAC-CON-11-10-31

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(Q60672438)

Synthesis and biological activities of chaetocin and its derivatives

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