(Q60683152)

English

Role of Interleukin (IL)-2 Receptor β-Chain Subdomains and Shc in p38 Mitogen-activated Protein (MAP) Kinase and p54 MAP Kinase (Stress-activated Protein Kinase/c-Jun N-terminal Kinase) Activation

scientific article published in Journal of Biological Chemistry

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scholarly article

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10066828%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

Role of interleukin (IL)-2 receptor beta-chain subdomains and Shc in p38 mitogen-activated protein (MAP) kinase and p54 MAP kinase (stress-activated protein Kinase/c-Jun N-terminal kinase) activation. IL-2-driven proliferation is independent of p38 and p54 MAP kinase activation (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10066828%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

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2

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11 November 2019

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10066828%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

Kevin J. Tracey

6

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11 November 2019

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A E Hunt

1

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11 November 2019

J D Lord

3

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11 November 2019

T Miyazaki

5

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11 November 2019

B M Foxwell

7

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11 November 2019

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publication date

1 March 1999

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11 November 2019

Journal of Biological Chemistry

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11 November 2019

274

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11 November 2019

11

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11 November 2019

7591-7597

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10066828%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

Interleukin-2: inception, impact, and implications

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

Interleukin 2 and its receptors: recent advances and new immunological functions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

A restricted cytoplasmic region of IL-2 receptor beta chain is essential for growth signal transduction but not for ligand binding and internalization

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

Growth signal transduction by the human interleukin-2 receptor requires cytoplasmic tyrosines of the beta chain and non-tyrosine residues of the gamma c chain.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

Protein tyrosine kinase Syk is associated with and activated by the IL-2 receptor: possible link with the c-myc induction pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

Interaction of the IL-2 receptor with the src-family kinase p56lck: identification of novel intermolecular association

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

Dispensability of Jak1 tyrosine kinase for interleukin-2-induced cell growth signaling in a human T cell line

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

Defective lymphoid development in mice lacking Jak3

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

Defects in B lymphocyte maturation and T lymphocyte activation in mice lacking Jak3

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

Interleukin 2- and polyomavirus middle T antigen-induced modification of phosphatidylinositol 3-kinase activity in activated T lymphocytes

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

Phosphatidylinositol 3-kinase links the interleukin-2 receptor to protein kinase B and p70 S6 kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

Interleukin 2 stimulation of p70 S6 kinase activity is inhibited by the immunosuppressant rapamycin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

Phosphatidylinositol 3-kinase couples the interleukin-2 receptor to the cell cycle regulator E2F

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

Involvement of ras p21 protein in signal-transduction pathways from interleukin 2, interleukin 3, and granulocyte/macrophage colony-stimulating factor, but not from interleukin 4

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

Interleukin 2 induces tyrosine phosphorylation and activation of p72-74 Raf-1 kinase in a T-cell line

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

Interleukin-2-triggered Raf-1 expression, phosphorylation, and associated kinase activity increase through G1 and S in CD3-stimulated primary human T cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

Analysis of interleukin-2-dependent signal transduction through the Shc/Grb2 adapter pathway. Interleukin-2-dependent mitogenesis does not require Shc phosphorylation or receptor association

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

Interaction of Shc with Grb2 regulates association of Grb2 with mSOS

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

Interleukin-7 induces T cell proliferation in the absence of Erk/MAP kinase activity

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

The stress-activated protein kinase subfamily of c-Jun kinases

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

A protein kinase involved in the regulation of inflammatory cytokine biosynthesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

T cell proliferation in response to interleukins 2 and 7 requires p38MAP kinase activation.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

Selective activation of JNK/SAPK by interleukin-1 in rabbit liver is mediated by MKK7

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

The murine T cell line CT6 provides a novel bioassay for interleukin-7.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

Suppression of proinflammatory cytokines in monocytes by a tetravalent guanylhydrazone

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

CNI-1493 inhibits monocyte/macrophage tumor necrosis factor by suppression of translation efficiency.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

A synthetic inhibitor of the mitogen-activated protein kinase cascade

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

The p38-MAPK inhibitor, SB203580, inhibits cardiac stress-activated protein kinases/c-Jun N-terminal kinases (SAPKs/JNKs)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

Role of p38 and JNK mitogen-activated protein kinases in the activation of ternary complex factors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

Targeted suppression of cytokine production in monocytes but not in T lymphocytes by a tetravalent guanylhydrazone (CNI-1493)

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

The tetravalent guanylhydrazone CNI-1493 blocks the toxic effects of interleukin-2 without diminishing antitumor efficacy

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.11.7591

21 January 2018

Identifiers

10.1074/JBC.274.11.7591

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10066828%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10066828%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

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