(Q60705828)

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29 January 2020

title

Enantioselective pharmacokinetics of tramadol in CYP2D6 extensive and poor metabolizers (English)

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29 January 2020

1 reference

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3

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29 January 2020

author name string

Rasmus Steen Pedersen

series ordinal

1

1 reference

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29 January 2020

Per Damkier

series ordinal

2

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29 January 2020

publication date

9 June 2006

1 reference

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European Journal of Clinical Pharmacology

29 January 2020

published in

1 reference

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29 January 2020

volume

62

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29 January 2020

issue

7

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29 January 2020

page(s)

513-521

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https://scigraph.springernature.com/pub.10.1007/s00228-006-0135-x

29 January 2020

exact match

0 references

cites work

Debrisoquine oxidation polymorphism: phenotypic consequences of a 3-base-pair deletion in exon 5 of the CYP2D6 gene

1 reference

12 December 2020

The effects of tramadol on static and dynamic pupillometry in healthy subjects--the relationship between pharmacodynamics, pharmacokinetics and CYP2D6 metaboliser status

1 reference

12 December 2020

Stereoselectivity in trans-tramadol metabolism and trans-O-demethyltramadol formation in rat liver microsomes.

1 reference

12 December 2020

Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic

1 reference

12 December 2020

Tramadol--present and future

1 reference

12 December 2020

Metabolism of the analgesic drug ULTRAM (tramadol hydrochloride) in humans: API-MS and MS/MS characterization of metabolites

1 reference

12 December 2020

Pharmacokinetics of tramadol and bioavailability of enteral tramadol formulations. 2nd communication: drops with ethanol.

1 reference

12 December 2020

Pharmacokinetics of tramadol and bioavailability of enteral tramadol formulations. 4th communication: drops (without ethanol).

1 reference

12 December 2020

Tramadol. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in acute and chronic pain states

1 reference

12 December 2020

Gas chromatographic determination of sparteine and 2- and 5-dehydrosparteine in plasma and urine

1 reference

12 December 2020

Identification of a new variant CYP2D6 allele with a single base deletion in exon 3 and its association with the poor metabolizer phenotype

1 reference

12 December 2020

Biotransformation of tramadol in man and animal (author's transl)

1 reference

12 December 2020

Cloning and sequencing of a new non-functional CYP2D6 allele: deletion of T1795 in exon 3 generates a premature stop codon

1 reference

12 December 2020

Affinity, potency and efficacy of tramadol and its metabolites at the cloned human mu-opioid receptor

1 reference

12 December 2020

Complementary and synergistic antinociceptive interaction between the enantiomers of tramadol

1 reference

12 December 2020

Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes

1 reference

12 December 2020

Sparteine oxidation polymorphism in Denmark.

1 reference

12 December 2020

Clinical pharmacology of tramadol

1 reference

12 December 2020

CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants

1 reference

12 December 2020

Actions of tramadol, its enantiomers and principal metabolite, O-desmethyltramadol, on serotonin (5-HT) efflux and uptake in the rat dorsal raphe nucleus

1 reference

12 December 2020

Effects of tramadol stereoisomers on norepinephrine efflux and uptake in the rat locus coeruleus measured by real time voltammetry.

1 reference

12 December 2020

The human CYP2D locus associated with a common genetic defect in drug oxidation: a G1934----A base change in intron 3 of a mutant CYP2D6 allele results in an aberrant 3' splice recognition site

1 reference

12 December 2020

Identification of a new variant CYP2D6 allele lacking the codon encoding Lys-281: possible association with the poor metabolizer phenotype

1 reference

12 December 2020

Bioavailability of enteral tramadol formulations. 1st communication: capsules

1 reference

12 December 2020

Tramadol as a new probe for cytochrome P450 2D6 phenotyping: a population study

1 reference

12 December 2020

Impact of CYP2D6 genotype on postoperative tramadol analgesia

1 reference

12 December 2020

Identification of the primary gene defect at the cytochrome P450 CYP2D locus.

1 reference

12 December 2020

The hypoalgesic effect of tramadol in relation to CYP2D6*

1 reference

12 December 2020

Polymorphism of CYP2D6, CYP2C19, CYP2C9 and CYP2C8 in the Faroese population

1 reference

12 December 2020

Tramadol hydrochloride: an overview of current use.

1 reference

12 December 2020

The analgesic effect of tramadol after intravenous injection in healthy volunteers in relation to CYP2D6.

1 reference

12 December 2020

Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: characterization of 48 mutations and 53 alleles, their frequencies and evolution.

1 reference

12 December 2020

The metabolism of tramadol by human liver microsomes

1 reference

12 December 2020

Pharmacokinetics of tramadol and bioavailability of enteral tramadol formulations. 3rd Communication: suppositories.

1 reference

12 December 2020

An inactive cytochrome P450 CYP2D6 allele containing a deletion and a base substitution

1 reference

12 December 2020

Multiple mutations of the human cytochrome P450IID6 gene (CYP2D6) in poor metabolizers of debrisoquine. Study of the functional significance of individual mutations by expression of chimeric genes

1 reference

12 December 2020

On separation of isomeres, structural elucidation and pharmacological characterization of 1-(m-methoxyphenyl)-2-(dimethylaminomethyl)-cyclohexan-1-ol (author's transl)

1 reference

12 December 2020

Paroxetine, a cytochrome P450 2D6 inhibitor, diminishes the stereoselective O-demethylation and reduces the hypoalgesic effect of tramadol

1 reference

12 December 2020

Tramadol, M1 metabolite and enantiomer affinities for cloned human opioid receptors expressed in transfected HN9.10 neuroblastoma cells

1 reference

12 December 2020

Tramadol--the impact of its pharmacokinetic and pharmacodynamic properties on the clinical management of pain

1 reference

12 December 2020

Polymorphic CYP2D6 mediates O-demethylation of the opioid analgesic tramadol

1 reference

12 December 2020

10.1007/S00228-006-0135-X

Identifiers

DOI

1 reference

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29 January 2020

1 reference