(Q60860281)

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Association Analysis of Genetic Polymorphisms in Genes Related to Sunitinib Pharmacokinetics, Specifically Clearance of Sunitinib and SU12662

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24566734%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

Association analysis of genetic polymorphisms in genes related to sunitinib pharmacokinetics, specifically clearance of sunitinib and SU12662 (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24566734%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

pharmacokinetics

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based on heuristic

inferred from title

Meta H Diekstra

1

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8 March 2020

8

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8 March 2020

9

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8 March 2020

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H J Klümpen

2

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8 March 2020

M P J K Lolkema

3

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8 March 2020

H Yu

4

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8 March 2020

J S L Kloth

5

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8 March 2020

H Gelderblom

6

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8 March 2020

R H N van Schaik

7

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8 March 2020

A D R Huitema

10

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8 March 2020

N Steeghs

11

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8 March 2020

R H J Mathijssen

12

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8 March 2020

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24 February 2014

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8 March 2020

Clinical Pharmacology & Therapeutics

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8 March 2020

96

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8 March 2020

1

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8 March 2020

81-89

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Europe PubMed Central

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8 March 2020

Pharmacogenetic pathway analysis for determination of sunitinib-induced toxicity

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.47

7 January 2021

based on heuristic

inferred from DOI database lookup

Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal-cell carcinoma treated with first-line sunitinib: a multicentre, observational, prospective study

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.47

7 January 2021

based on heuristic

inferred from DOI database lookup

Genetic polymorphisms associated with a prolonged progression-free survival in patients with metastatic renal cell cancer treated with sunitinib

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.47

7 January 2021

based on heuristic

inferred from DOI database lookup

A population pharmacokinetic meta-analysis of sunitinib malate (SU11248) and its primary metabolite (SU12662) in healthy volunteers and oncology patients

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.47

7 January 2021

based on heuristic

inferred from DOI database lookup

Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.47

7 January 2021

based on heuristic

inferred from DOI database lookup

Activity of sunitinib in patients with advanced neuroendocrine tumors

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.47

7 January 2021

based on heuristic

inferred from DOI database lookup

Novel single nucleotide polymorphisms in the promoter and intron 1 of human pregnane X receptor/NR1I2 and their association with CYP3A4 expression

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.47

7 January 2021

based on heuristic

inferred from DOI database lookup

Brain accumulation of sunitinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.47

7 January 2021

based on heuristic

inferred from DOI database lookup

Opposing regulation of cytochrome P450 expression by CAR and PXR in hypothyroid mice

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.47

7 January 2021

based on heuristic

inferred from DOI database lookup

Relationship between exposure to sunitinib and efficacy and tolerability endpoints in patients with cancer: results of a pharmacokinetic/pharmacodynamic meta-analysis.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.47

7 January 2021

based on heuristic

inferred from DOI database lookup

Hypertension as a biomarker of efficacy in patients with metastatic renal cell carcinoma treated with sunitinib

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.47

7 January 2021

based on heuristic

inferred from DOI database lookup

A new functional CYP3A4 intron 6 polymorphism significantly affects tacrolimus pharmacokinetics in kidney transplant recipients.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.47

7 January 2021

based on heuristic

inferred from DOI database lookup

CYP3A4 intron 6 C>T SNP (CYP3A4*22) encodes lower CYP3A4 activity in cancer patients, as measured with probes midazolam and erythromycin

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.47

7 January 2021

based on heuristic

inferred from DOI database lookup

CYP3A4*22 genotype and systemic exposure affect paclitaxel-induced neurotoxicity.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.47

7 January 2021

based on heuristic

inferred from DOI database lookup

The P450 oxidoreductase *28 SNP is associated with low initial tacrolimus exposure and increased dose requirements in CYP3A5-expressing renal recipients

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.47

7 January 2021

based on heuristic

inferred from DOI database lookup

Impact of POR*28 on the clinical pharmacokinetics of CYP3A phenotyping probes midazolam and erythromycin.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.47

7 January 2021

based on heuristic

inferred from DOI database lookup

CYP3A4*22: promising newly identified CYP3A4 variant allele for personalizing pharmacotherapy

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.47

7 January 2021

based on heuristic

inferred from DOI database lookup

Pazopanib efficacy in renal cell carcinoma: evidence for predictive genetic markers in angiogenesis-related and exposure-related genes.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.47

7 January 2021

based on heuristic

inferred from DOI database lookup

The P450 oxidoreductase genotype is associated with CYP3A activity in vivo as measured by the midazolam phenotyping test

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.47

7 January 2021

based on heuristic

inferred from DOI database lookup

Predictive value of CYP3A and ABCB1 phenotyping probes for the pharmacokinetics of sunitinib: the ClearSun study

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.47

7 January 2021

based on heuristic

inferred from DOI database lookup

Midazolam as a phenotyping probe to predict sunitinib exposure in patients with cancer

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.47

7 January 2021

based on heuristic

inferred from DOI database lookup

PKPD Modeling of Predictors for Adverse Effects and Overall Survival in Sunitinib-Treated Patients With GIST.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.47

7 January 2021

based on heuristic

inferred from DOI database lookup

PKPD Modeling of VEGF, sVEGFR-2, sVEGFR-3, and sKIT as Predictors of Tumor Dynamics and Overall Survival Following Sunitinib Treatment in GIST

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.47

7 January 2021

based on heuristic

inferred from DOI database lookup

Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.47

7 January 2021

based on heuristic

inferred from DOI database lookup

Population analysis of erlotinib in adults and children reveals pharmacokinetic characteristics as the main factor explaining tolerance particularities in children.

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.47

7 January 2021

based on heuristic

inferred from DOI database lookup

Pharmacogenomics of Cytochrome P450 3A4: Recent Progress Toward the "Missing Heritability" Problem

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.47

7 January 2021

based on heuristic

inferred from DOI database lookup

Genetic epidemiology of induced CYP3A4 activity

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.47

7 January 2021

based on heuristic

inferred from DOI database lookup

Evidence for therapeutic drug monitoring of targeted anticancer therapies

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.47

7 January 2021

based on heuristic

inferred from DOI database lookup

Quantification of sunitinib and N-desethyl sunitinib in human EDTA plasma by liquid chromatography coupled with electrospray ionization tandem mass spectrometry: validation and application in routine therapeutic drug monitoring

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.47

7 January 2021

based on heuristic

inferred from DOI database lookup

PLINK: a tool set for whole-genome association and population-based linkage analyses

1 reference

https://api.crossref.org/works/10.1038%2FCLPT.2014.47

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/CLPT.2014.47

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24566734%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24566734%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

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