(Q61510374)

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Calcium-sensitive pyruvate dehydrogenase phosphatase is required for energy metabolism, growth, differentiation, and infectivity of

scientific article published in Journal of Biological Chemistry

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30232153%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

Calcium-sensitive pyruvate dehydrogenase phosphatase is required for energy metabolism, growth, differentiation, and infectivity of Trypanosoma cruzi (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30232153%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

pyruvate dehydrogenase phosphatase, putative

1 reference

5 February 2019

pyruvate dehydrogenase phosphatase

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1 reference

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Miguel A Chiurillo

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30232153%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

Roberto Docampo

6

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Europe PubMed Central

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23 April 2020

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Noelia Lander

1

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23 April 2020

Mayara S Bertolini

3

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23 April 2020

Melissa Storey

4

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23 April 2020

Anibal E Vercesi

5

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23 April 2020

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publication date

19 September 2018

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Europe PubMed Central

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23 April 2020

Journal of Biological Chemistry

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30232153%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

293

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23 April 2020

45

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30232153%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

17402-17417

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30232153%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

Regulation of mammalian pyruvate dehydrogenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amino acid sequences around the sites of phosphorylation in the pig heart pyruvate dehydrogenase complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sites of phosphorylation on pyruvate dehydrogenase from bovine kidney and heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Energization-dependent Ca2+ accumulation in Trypanosoma brucei bloodstream and procyclic trypomastigotes mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium homeostasis in procyclic and bloodstream forms of Trypanosoma brucei. Lack of inositol 1,4,5-trisphosphate-sensitive Ca2+ release

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Calcium homeostasis in Trypanosoma cruzi amastigotes: presence of inositol phosphates and lack of an inositol 1,4,5-trisphosphate-sensitive calcium pool

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of calcium ions in regulation of mammalian intramitochondrial metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ca2+ as a second messenger within mitochondria of the heart and other tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ca2+ transport by coupled Trypanosoma cruzi mitochondria in situ

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characteristics of Ca2+ transport by Trypanosoma cruzi mitochondria in situ

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation-dephosphorylation of pyruvate dehydrogenase from bakers' yeast

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alpha-keto acid dehydrogenase complexes. X. Regulation of the activity of the pyruvate dehydrogenase complex from beef kidney mitochondria by phosphorylation and dephosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stimulation by calcium ions of pyruvate dehydrogenase phosphate phosphatase

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The kinetic properties of citrate synthase from rat liver mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and properties of pyruvate dehydrogenase phosphatase from bovine heart and kidney

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cultivation of Trypanosoma cruzi in irradiated muscle cells: improved synchronization and enhanced trypomastigote production

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comparative study of the regulation of Ca2+ of the activities of the 2-oxoglutarate dehydrogenase complex and NAD+-isocitrate dehydrogenase from a variety of sources

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cytosolic-free calcium elevation in Trypanosoma cruzi is required for cell invasion

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thapsigargin causes Ca2+ release and collapse of the membrane potential of Trypanosoma brucei mitochondria in situ and of isolated rat liver mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trypanosoma cruzi: involvement of intracellular calcium in multiplication and differentiation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A putative pyruvate dehydrogenase alpha subunit gene from Trypanosoma cruzi.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective transfer of calcium from an acidic compartment to the mitochondrion of Trypanosoma brucei. Measurements with targeted aequorins

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isoenzymes of pyruvate dehydrogenase phosphatase. DNA-derived amino acid sequences, expression, and regulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of lectin-binding sites on the surface of Trypanosoma cruzi grown in chemically defined conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A novel phosphatidylinositol-phospholipase C of Trypanosoma cruzi that is lipid modified and activated during trypomastigote to amastigote differentiation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Arginine kinase of the flagellate protozoa Trypanosoma cruzi. Regulation of its expression and catalytic activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A trail of research from lipoic acid to alpha-keto acid dehydrogenase complexes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate dehydrogenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation and mitochondrial translocation of protein kinase Cdelta are necessary for insulin stimulation of pyruvate dehydrogenase complex activity in muscle and liver cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulatory volume decrease in Trypanosoma cruzi involves amino acid efflux and changes in intracellular calcium

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of pyruvate dehydrogenase complex activity in plant cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Starvation and diabetes reduce the amount of pyruvate dehydrogenase phosphatase in rat heart and kidney

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isotopes incorporated in the Nucleic Acids of Trypanosoma mega

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of a complex of the catalytic subunit of pyruvate dehydrogenase phosphatase isoform 1 (PDP1c) and the L2 domain forms a Ca2+ binding site and captures PDP1c as a monomer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Trypanosoma cruzi proteome.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A vector series for rapid PCR-mediated C-terminal in situ tagging of Trypanosoma brucei genes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of the pyruvate dehydrogenase complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ScanProsite: detection of PROSITE signature matches and ProRule-associated functional and structural residues in proteins

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Crystal Structure of Pyruvate Dehydrogenase Phosphatase 1 and its Functional Implications

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autophagy is involved in nutritional stress response and differentiation in Trypanosoma cruzi

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of mitochondrial dehydrogenases by calcium ions

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose uptake in the mammalian stages of Trypanosoma cruzi.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization and developmental regulation of a dispersed gene family 1 protein in Trypanosoma cruzi

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TriTrypDB: a functional genomic resource for the Trypanosomatidae

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The relationship between human skeletal muscle pyruvate dehydrogenase phosphatase activity and muscle aerobic capacity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The higher susceptibility of congenital analbuminemic rats to Ca2+-induced mitochondrial permeability transition is associated with the increased expression of cyclophilin D and nitrosothiol depletion.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose metabolism in Trypanosoma cruzi

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High-resolution respirometry: OXPHOS protocols for human cells and permeabilized fibers from small biopsies of human muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Safranine as a fluorescent probe for the evaluation of mitochondrial membrane potential in isolated organelles and permeabilized cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trypanosomes and the solution to a 50-year mitochondrial calcium mystery

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Proteome remodelling during development from blood to insect-form Trypanosoma brucei quantified by SILAC and mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MCUR1 is an essential component of mitochondrial Ca2+ uptake that regulates cellular metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trypanosoma brucei vacuolar transporter chaperone 4 (TbVtc4) is an acidocalcisome polyphosphate kinase required for in vivo infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EMRE is an essential component of the mitochondrial calcium uniporter complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Essential regulation of cell bioenergetics in Trypanosoma brucei by the mitochondrial calcium uniporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mitochondrial calcium transport in trypanosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CRISPR/Cas9-Induced Disruption of Paraflagellar Rod Protein 1 and 2 Genes in Trypanosoma cruzi Reveals Their Role in Flagellar Attachment

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rationally engineered Cas9 nucleases with improved specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genome Editing by CRISPR/Cas9: A Game Change in the Genetic Manipulation of Protists

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CRISPR/Cas9-mediated endogenous C-terminal Tagging of Trypanosoma cruzi Genes Reveals the Acidocalcisome Localization of the Inositol 1,4,5-Trisphosphate Receptor.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

InterPro in 2017-beyond protein family and domain annotations

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

ATP-driven and AMPK-independent autophagy in an early branching eukaryotic parasite.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

EuPaGDT: a web tool tailored to design CRISPR guide RNAs for eukaryotic pathogens

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Programmatic access to bioinformatics tools from EMBL-EBI update: 2017

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Different Roles of Mitochondrial Calcium Uniporter Complex Subunits in Growth and Infectivity of Trypanosoma cruzi

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrative proteomics and biochemical analyses define Ptc6p as the Saccharomyces cerevisiae pyruvate dehydrogenase phosphatase

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Endogenous C-terminal Tagging by CRISPR/Cas9 in Trypanosoma cruzi.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dynamic nuclear polarization facilitates monitoring of pyruvate metabolism in Trypanosoma brucei

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mitochondrial calcium uniporter complex in trypanosomes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The glutamine synthetase of Trypanosoma cruzi is required for its resistance to ammonium accumulation and evasion of the parasitophorous vacuole during host-cell infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An Intracellular Ammonium Transporter Is Necessary for Replication, Differentiation, and Resistance to Starvation and Osmotic Stress in Trypanosoma cruzi.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipoic acid metabolism in Trypanosoma cruzi as putative target for chemotherapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Mitochondrial Ca Uniporter Complex (MCUC) of Trypanosoma brucei Is a Hetero-oligomer That Contains Novel Subunits Essential for Ca Uptake

1 reference

https://pubmed.ncbi.nlm.nih.gov/30232153

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.RA118.004498

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30232153%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30232153%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30232153%20AND%20SRC:MED&resulttype=core&format=json

23 April 2020

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