(Q61656595)

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Differential effects of monophosphoryl lipid A and cytokine cocktail as maturation stimuli of immunogenic and tolerogenic dendritic cells for immunotherapy

scientific article published on 12 November 2011

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16 January 2020

Differential effects of monophosphoryl lipid A and cytokine cocktail as maturation stimuli of immunogenic and tolerogenic dendritic cells for immunotherapy (English)

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16 January 2020

molecular medicine

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R Pujol-Borrell

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16 January 2020

Eva Martínez-Cáceres

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16 January 2020

Francesc E. Borràs

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16 January 2020

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Dàlia Raïch-Regué

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16 January 2020

Mar Naranjo-Gómez

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16 January 2020

Laia Grau-López

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Cristina Ramo

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12 November 2011

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378-387

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16 January 2020

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Dendritic cells matured by a prostaglandin E2-containing cocktail can produce high levels of IL-12p70 and are more mature and Th1-biased than dendritic cells treated with TNF-α or LPS

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The adjuvant monophosphoryl lipid A increases the function of antigen-presenting cells

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Monophosphoryl lipid A (MPL) as an adjuvant for anti-cancer vaccines: clinical results.

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Commonly used prophylactic vaccines as an alternative for synthetically produced TLR ligands to mature monocyte-derived dendritic cells

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The clinical grade maturation cocktail monophosphoryl lipid A plus IFNgamma generates monocyte-derived dendritic cells with the capacity to migrate and induce Th1 polarization

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Monophosphoryl lipid A plus IFNgamma maturation of dendritic cells induces antigen-specific CD8+ cytotoxic T cells with high cytolytic potential

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Cutting edge: different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos.

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Increased tumor-specific CD8+ T cell induction by dendritic cells matured with a clinical grade TLR-agonist in combination with IFN-gamma.

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7 January 2021

Monophosphoryl lipid A activates both human dendritic cells and T cells

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Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma

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In vivo activated monocytes from the site of inflammation in humans specifically promote Th17 responses

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Dendritic Cells Matured With TNF can be Further Activated In Vitro and After Subcutaneous Injection In Vivo Which Converts Their Tolerogenicity Into Immunogenicity

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10.1016/J.VACCINE.2011.10.081

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Europe PubMed Central

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16 January 2020

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Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22085546%20AND%20SRC:MED&resulttype=core&format=json

16 January 2020

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