(Q61718084)

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Codon and mRNA Sequence Optimization of Microdystrophin Transgenes Improves Expression and Physiological Outcome in Dystrophic mdx Mice Following AAV2/8 Gene Transfer

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13 January 2020

Codon and mRNA sequence optimization of microdystrophin transgenes improves expression and physiological outcome in dystrophic mdx mice following AAV2/8 gene transfer (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18766174%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

molecular medicine

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Capucine Trollet

4

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18766174%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

Dominic J Wells

7

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13 January 2020

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Helen Foster

1

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13 January 2020

Paul S Sharp

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13 January 2020

Takis Athanasopoulos

3

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13 January 2020

Ian R Graham

5

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13 January 2020

Keith Foster

6

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13 January 2020

George Dickson

8

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13 January 2020

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2 September 2008

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13 January 2020

Molecular Therapy

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13 January 2020

16

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13 January 2020

11

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13 January 2020

1825-1832

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13 January 2020

Expression of human full-length and minidystrophin in transgenic mdx mice: implications for gene therapy of Duchenne muscular dystrophy

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

Dystrophin levels as low as 30% are sufficient to avoid muscular dystrophy in the human

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

Recombinant adeno-associated viral (rAAV) vectors as therapeutic tools for Duchenne muscular dystrophy (DMD).

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

Adeno-associated virus vector gene transfer and sarcolemmal expression of a 144 kDa micro-dystrophin effectively restores the dystrophin-associated protein complex and inhibits myofibre degeneration in nude/mdx mice

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

rAAV6-microdystrophin preserves muscle function and extends lifespan in severely dystrophic mice.

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

Systemic microdystrophin gene delivery improves skeletal muscle structure and function in old dystrophic mdx mice.

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

Systemic delivery of genes to striated muscles using adeno-associated viral vectors.

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

Modular flexibility of dystrophin: implications for gene therapy of Duchenne muscular dystrophy

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

Adeno-associated virus vector-mediated minidystrophin gene therapy improves dystrophic muscle contractile function in mdx mice

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

Functional capacity of dystrophins carrying deletions in the N-terminal actin-binding domain

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

Adeno-associated virus-mediated microdystrophin expression protects young mdx muscle from contraction-induced injury.

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

Unrestricted hepatocyte transduction with adeno-associated virus serotype 8 vectors in mice

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

DNA vaccines: improving expression of antigens

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

Regulation of translation via mRNA structure in prokaryotes and eukaryotes

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

Optimisation of a multipartite human immunodeficiency virus based vector system; control of virus infectivity and large-scale production

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

Optimisation of secretion of recombinant HBsAg virus-like particles: Impact on the development of HIV-1/HBV bivalent vaccines

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

Codon usage in muscle genes and liver genes

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

A+U-rich instability elements differentially activate 5'-3' and 3'-5' mRNA decay.

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

Reversal of blindness in animal models of leber congenital amaurosis using optimized AAV2-mediated gene transfer

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

Analysis of factor VIII mediated suppression of lentiviral vector titres

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

Clades of Adeno-associated viruses are widely disseminated in human tissues.

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

New recombinant serotypes of AAV vectors.

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

Robust systemic transduction with AAV9 vectors in mice: efficient global cardiac gene transfer superior to that of AAV8.

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

Adeno-associated virus serotype 8 efficiently delivers genes to muscle and heart

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

Emergent dilated cardiomyopathy caused by targeted repair of dystrophic skeletal muscle

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

Analysis of AAV serotypes 1-9 mediated gene expression and tropism in mice after systemic injection

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

AAV vector-mediated microdystrophin expression in a relatively small percentage of mdx myofibers improved the mdx phenotype

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

Dissecting the signaling and mechanical functions of the dystrophin-glycoprotein complex

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of full-length and truncated dystrophin mini-genes in transgenic mdx mice

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

Expression of Dp260 in muscle tethers the actin cytoskeleton to the dystrophin-glycoprotein complex and partially prevents dystrophy.

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

Transgenic mdx mice expressing dystrophin with a deletion in the actin-binding domain display a "mild Becker" phenotype

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

Development of multiple cloning site cis-vectors for recombinant adeno-associated virus production

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

Synthetic muscle promoters: activities exceeding naturally occurring regulatory sequences

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

Optimized production of high-titer recombinant adeno-associated virus in roller bottles

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

High-efficiency plasmid gene transfer into dystrophic muscle

1 reference

https://api.crossref.org/works/10.1038%2FMT.2008.186

7 January 2021

based on heuristic

inferred from DOI database lookup

Identifiers

10.1038/MT.2008.186

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18766174%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18766174%20AND%20SRC:MED&resulttype=core&format=json

13 January 2020

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