(Q61757674)

English

Radiodefluorination of 3-fluoro-5-(2-(2-[18F](fluoromethyl)-thiazol-4-yl)ethynyl)benzonitrile ([18F]SP203), a radioligand for imaging brain metabotropic glutamate subtype-5 receptors with positron emission tomography, occurs by glutathionylation in r

scientific article published on 19 September 2008

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18806125%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

Radiodefluorination of 3-fluoro-5-(2-(2-[18F](fluoromethyl)-thiazol-4-yl)ethynyl)benzonitrile ([18F]SP203), a radioligand for imaging brain metabotropic glutamate subtype-5 receptors with positron emission tomography, occurs by glutathionylation in rat brain (English)

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14 January 2020

positron emission tomography

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14 January 2020

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H Umesha Shetty

1

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14 January 2020

Sami S Zoghbi

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14 January 2020

Fabrice G Siméon

3

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14 January 2020

Jeih-San Liow

4

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14 January 2020

Amira K Brown

5

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14 January 2020

Robert B Innis

7

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14 January 2020

Victor W Pike

8

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14 January 2020

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19 September 2008

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14 January 2020

Journal of Pharmacology and Experimental Therapeutics

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14 January 2020

327

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14 January 2020

3

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14 January 2020

727-735

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14 January 2020

Mechanism for the oxidative defluorination of flunisolide

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabotropic glutamate subtype 5 receptors are quantified in the human brain with a novel radioligand for PET

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reactive intermediates and the dynamics of glutathione transferases

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutathione transferases catalyse the detoxication of oxidized metabolites (o-quinones) of catecholamines and may serve as an antioxidant system preventing degenerative cellular processes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism and functions of glutathione in brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanistic studies on the bioactivation of diclofenac: identification of diclofenac-S-acyl-glutathione in vitro in incubations with rat and human hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzymes and transport systems involved in the formation and disposition of glutathione S-conjugates. Role in bioactivation and detoxication mechanisms of xenobiotics.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of the fluoroacetate detoxication enzymes of rat liver cytosol

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liquid chromatography-tandem mass spectrometry identification of metabolites of two 5-HT1A antagonists, N-[2-[4-(2-methoxylphenyl)piperazino]ethyl]-N-(2-pyridyl) trans- and cis-4-fluorocyclohexanecarboxamide, produced by human and rat hepatocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of group I metabotropic glutamate receptors in schizophrenia

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mercapturate metabolism of 4-hydroxy-2-nonenal in rat and human cerebrum

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Correction of fragile X syndrome in mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Biologically stable [(18)F]-labeled benzylfluoride derivatives

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro microsomal metabolic studies on a selective mGluR5 antagonist MTEP: characterization of in vitro metabolites and identification of a novel thiazole ring opening aldehyde metabolite

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conjugation of haloalkanes by bacterial and mammalian glutathione transferases: mono- and vicinal dihaloethanes.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of group I metabotropic glutamate receptors in neuronal excitotoxicity in Alzheimer's disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Dopamine mercapturate can augment dopaminergic neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Synthesis and simple 18F-labeling of 3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile as a high affinity radioligand for imaging monkey brain metabotropic glutamate subtype-5 receptors with positron emission tomography.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anxiolytic-like activity of the mGluR5 antagonist MPEP: a comparison with diazepam and buspirone

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabotropic glutamate 5 receptor antagonism is associated with antidepressant-like effects in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification of a fluoroacetate-specific defluorinase from mouse liver cytosol

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Evidence for the bioactivation of zomepirac and tolmetin by an oxidative pathway: identification of glutathione adducts in vitro in human liver microsomes and in vivo in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Enzymatic defluorination and metabolism of fluoroacetate, fluoroacetamide, fluoroethanol, and (-)-erythro-fluorocitrate in rats and mice examined by 19F and 13C NMR

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relationships between radiotracer properties and image quality in molecular imaging of the brain with positron emission tomography

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stereochemical aspects of the glutathione S-transferase-catalyzed conjugations of alkyl halides

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The ups and downs of addiction: role of metabotropic glutamate receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conjugation of isoprene monoepoxides with glutathione, catalyzed by alpha, mu, pi and theta-class glutathione S-transferases of rat and man

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vitro metabolism of the epoxide substructure of cryptophycins by cytosolic glutathione S-transferase: species differences and stereoselectivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Skeletal PET with 18F-fluoride: applying new technology to an old tracer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Positron-emitting radioligands for studies in vivo-probes for human psychopharmacology

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Disulfiram inhibits defluorination of (18)F-FCWAY, reduces bone radioactivity, and enhances visualization of radioligand binding to serotonin 5-HT1A receptors in human brain.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanism of defluorination of enflurane. Identification of an organic metabolite in rat and man

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glutathione conjugation of trichloroethylene in rats and mice: sex-, species-, and tissue-dependent differences.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PET imaging of brain 5-HT1A receptors in rat in vivo with 18F-FCWAY and improvement by successful inhibition of radioligand defluorination with miconazole

1 reference

https://pubmed.ncbi.nlm.nih.gov/18806125

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1124/JPET.108.143347

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18806125%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18806125%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18806125%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

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