(Q61819782)

English

(-)-Adrenaline elicits positive inotropic, lusitropic, and biochemical effects through β2-adrenoceptors in human atrial myocardium from nonfailing and failing hearts, consistent with Gs coupling but not with Gi coupling

scientific article published on 13 February 2007

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scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17295024%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

(-)-Adrenaline elicits positive inotropic, lusitropic, and biochemical effects through beta2 -adrenoceptors in human atrial myocardium from nonfailing and failing hearts, consistent with Gs coupling but not with Gi coupling (English)

1 reference

Europe PubMed Central

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25 December 2019

Ian Anthony Yang

7

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25 December 2019

author name string

Peter Molenaar

1

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25 December 2019

Doreen Sarsero

3

1 reference

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25 December 2019

Lu Chen

4

1 reference

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25 December 2019

Anne Carle

6

1 reference

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25 December 2019

Sabine Bartel

8

1 reference

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25 December 2019

Donate Vetter

9

1 reference

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25 December 2019

Inge Beyerdörfer

10

1 reference

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25 December 2019

Ernst-Georg Krause

11

1 reference

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25 December 2019

Santiyagu M Savarimuthu

2

1 reference

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25 December 2019

Annalese B T Semmler

5

1 reference

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25 December 2019

Alberto J Kaumann

12

1 reference

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25 December 2019

publication date

13 February 2007

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25 December 2019

Naunyn-Schmiedeberg's Archives of Pharmacology

1 reference

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25 December 2019

375

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25 December 2019

11-28

1 reference

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25 December 2019

1

1 reference

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25 December 2019

https://scigraph.springernature.com/pub.10.1007/s00210-007-0138-x

0 references

Increased messenger RNA level of the inhibitory G protein alpha subunit Gi alpha-2 in human end-stage heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta 1- and beta 2-adrenergic-receptor subpopulations in nonfailing and failing human ventricular myocardium: coupling of both receptor subtypes to muscle contraction and selective beta 1-receptor down-regulation in heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Stepwise subunit interaction changes by mono- and bisphosphorylation of cardiac troponin I.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibitory G-proteins and their role in desensitization of the adenylyl cyclase pathway in heart failure.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of beta2-adrenergic receptors hastens relaxation and mediates phosphorylation of phospholamban, troponin I, and C-protein in ventricular myocardium from patients with terminal heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional coupling of the beta 2-adrenoceptor to a pertussis toxin-sensitive G protein in cardiac myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The affinity of (-)-propranolol for beta 1- and beta 2-adrenoceptors of human heart. Differential antagonism of the positive inotropic effects and adenylate cyclase stimulation by (-)-noradrenaline and (-)-adrenaline

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sensitization of human atrial 5-HT4 receptors by chronic beta-blocker treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta 2-adrenoceptor activation by zinterol causes protein phosphorylation, contractile effects and relaxant effects through a cAMP pathway in human atrium

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta 1- and beta 2-adrenergic receptor-mediated adenylate cyclase stimulation in nonfailing and failing human ventricular myocardium

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of phospholamban phosphorylation on Thr17 in cardiac physiological and pathological conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Long term beta-adrenoceptor-mediated up-regulation of Gi alpha and G(o) alpha mRNA levels and pertussis toxin-sensitive guanine nucleotide-binding proteins in rat heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Ile164 beta2-adrenergic receptor polymorphism adversely affects the outcome of congestive heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the phosphorylation of the inhibitory subunit of troponin during modification of contraction in perfused rat heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Functional serotonin 5-HT4 receptors in porcine and human ventricular myocardium with increased 5-HT4 mRNA in heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of metoprolol on myocardial beta-adrenoceptors and Gi alpha-proteins in patients with congestive heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increase in myocardial Gi-proteins in heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional differences of beta 1- and beta 2-adrenoceptor-mediated functions in feline heart. A beta 2-adrenoceptor-mediated positive inotropic effect possibly unrelated to cyclic AMP

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy of beta 1-adrenergic receptors is lower than that of beta 2-adrenergic receptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Discrimination between two sites of phosphorylation on adjacent amino acids by phosphorylation site-specific antibodies to phospholamban

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Carvedilol blocks beta2- more than beta1-adrenoceptors in human heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic beta 1-adrenoceptor antagonist treatment sensitizes beta 2-adrenoceptors, but desensitizes M2-muscarinic receptors in the human right atrium

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of calcineurin in human failing heart ventricle by endothelin-1, angiotensin II and urotensin II

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycolytic buffering affects cardiac bioenergetic signaling and contractile reserve similar to creatine kinase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

(-)-CGP 12177 increases contractile force and hastens relaxation of human myocardial preparations through a propranolol-resistant state of the beta 1-adrenoceptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tuning the human heart molecular motors by myosin light chains

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A simple salting out procedure for extracting DNA from human nucleated cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Both beta(2)- and beta(1)-adrenergic receptors mediate hastened relaxation and phosphorylation of phospholamban and troponin I in ventricular myocardium of Fallot infants, consistent with selective coupling of beta(2)-adrenergic receptors to G(s)-pr

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduced Ca(2+)-sensitivity of SERCA 2a in failing human myocardium due to reduced serin-16 phospholamban phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Emerging concepts and therapeutic implications of beta-adrenergic receptor subtype signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Isoprenaline stimulates gene transcription of the inhibitory G protein alpha-subunit Gi alpha-2 in rat heart.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Gln27Glu beta2-adrenoceptor polymorphism slows the onset of desensitization of cardiac functional responses in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunodetection of phosphorylation sites gives new insights into the mechanisms underlying phospholamban phosphorylation in the intact heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective beta1-adrenoceptor blockade enhances the activity of the stimulatory G-protein in human atrial myocardium

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

New insights into beta2-adrenoceptor signaling in the adult rat heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein phosphorylation in isolated trabeculae from nonfailing and failing human hearts

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacology and physiology of human adrenergic receptor polymorphisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phospholamban: a prominent regulator of myocardial contractility

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo demonstration of cardiac beta 2-adrenoreceptor sensitization by beta 1-antagonist treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta 2-adrenoceptor-mediated positive inotropic effect of adrenaline in human ventricular myocardium. Quantitative discrepancies with binding and adenylate cyclase stimulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of phospholamban phosphorylation catalyzed by adenosine 3′:5′-monophosphate- and calmodulin-dependent protein kinases on calcium transport ATPase of cardiac sarcoplasmic reticulum

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of type 1 protein phosphatase activity by activation of beta-adrenoceptors in ventricular myocardium

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glycolysis supports calcium uptake by the sarcoplasmic reticulum in skinned ventricular fibres of mice deficient in mitochondrial and cytosolic creatine kinase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta(2)-adrenergic and several other G protein-coupled receptors in human atrial membranes activate both G(s) and G(i).

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The endogenous cardiac sarcoplasmic reticulum Ca2+/calmodulin-dependent kinase is activated in response to beta-adrenergic stimulation and becomes Ca2+-independent in intact beating hearts

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional expression of phospholamban in the human heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta2-adrenergic receptor polymorphisms at amino acid 16 differentially influence agonist-stimulated blood pressure and peripheral blood flow in normal individuals.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conservation of the cardiostimulant effects of (-)-norepinephrine across Ser49Gly and Gly389Arg beta(1)-adrenergic receptor polymorphisms in human right atrium in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A common motif of two adjacent phosphoserines in bovine, rabbit and human cardiac troponin I

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Alteration of myosin cross bridges by phosphorylation of myosin-binding protein C in cardiac muscle

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regional distribution of beta-adrenoceptors in the human heart: coexistence of functional beta 1- and beta 2-adrenoceptors in both atria and ventricles in severe congestive cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of pertussis toxin on beta-adrenoceptor responses in isolated cardiac myocytes from noradrenaline-treated guinea-pigs and patients with cardiac failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chronic beta 1-adrenoceptor blockade sensitises the H1 and H2 receptor systems in human atrium: rôle of cyclic nucleotides

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of Ca2+ transport by cyclic 3',5'-AMP-dependent and calcium-calmodulin-dependent phosphorylation of cardiac sarcoplasmic reticulum

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protein measurement with the Folin phenol reagent

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of potassium and calcium ions in the effect of epinephrine on cardiac cyclic adenosine 3',5'-monophosphate, phosphorylase kinase, and phosphorylase

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Myocardial signaling defects and impaired cardiac function of a human beta 2-adrenergic receptor polymorphism expressed in transgenic mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phosphorylation and functional modifications of sarcoplasmic reticulum and myofibrils in isolated rabbit hearts stimulated with isoprenaline

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of (-)-RO363 at human atrial beta-adrenoceptor subtypes, the human cloned beta 3-adrenoceptor and rodent intestinal beta 3-adrenoceptors

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Selective beta 1-adrenoceptor blockade enhances positive inotropic responses to endogenous catecholamines mediated through beta 2-adrenoceptors in human atrial myocardium

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cilostamide potentiates more the positive inotropic effects of (-)-adrenaline through beta(2)-adrenoceptors than the effects of (-)-noradrenaline through beta (1)-adrenoceptors in human atrial myocardium

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

beta2-adrenergic cAMP signaling is uncoupled from phosphorylation of cytoplasmic proteins in canine heart

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A protein binding assay for adenosine 3':5'-cyclic monophosphate

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A comparison of the effects of adrenaline and noradrenaline on human heart: the role of beta 1- and beta 2-adrenoceptors in the stimulation of adenylate cyclase and contractile force

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A polymorphism of the human beta 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential sensitivity to isoprenaline of troponin I and phospholamban phosphorylation in isolated rat hearts

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Beta 2-adrenergic receptor-stimulated increase in cAMP in rat heart cells is not coupled to changes in Ca2+ dynamics, contractility, or phospholamban phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17295024

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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