(Q61863501)

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Type I IFNs differentially modulate IL-12p70 production by human dendritic cells depending on the maturation status of the cells and counteract IFN-γ-mediated signaling

scientific article published in June 2003

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Europe PubMed Central

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4 November 2019

Type I IFNs differentially modulate IL-12p70 production by human dendritic cells depending on the maturation status of the cells and counteract IFN-gamma-mediated signaling (English)

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Europe PubMed Central

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4 November 2019

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4 November 2019

author name string

Heystek HC

1

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4 November 2019

den Drijver B

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12804530%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

Kapsenberg ML

3

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4 November 2019

de Jong EC

5

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4 November 2019

publication date

1 June 2003

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4 November 2019

Clinical Immunology

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12804530%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

107

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4 November 2019

3

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4 November 2019

170-177

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Europe PubMed Central

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4 November 2019

Combination therapy with interferon and ribavirin in the treatment of chronic hepatitis C infection

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Maturation, activation, and protection of dendritic cells induced by double-stranded RNA

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Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells.

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High-level IL-12 production by human dendritic cells requires two signals

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Interleukin-12: a cytokine at the interface of inflammation and immunity

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Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products

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Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha

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Differential secretion of TNF-alpha and IFN-gamma by human peripheral blood-derived NK subsets and association with functional maturation

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Two roads diverged: interferon alpha/beta- and interleukin 12-mediated pathways in promoting T cell interferon gamma responses during viral infection

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Selective expression of an interleukin-12 receptor component by human T helper 1 cells

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7 January 2021

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Interferon-alpha/beta inhibition of interleukin 12 and interferon-gamma production in vitro and endogenously during viral infection

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7 January 2021

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Type I interferons and IL-12: convergence and cross-regulation among mediators of cellular immunity

1 reference

https://api.crossref.org/works/10.1016%2FS1521-6616%2803%2900060-3

7 January 2021

based on heuristic

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IFN-alpha enhances CD40 ligand-mediated activation of immature monocyte-derived dendritic cells.

1 reference

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7 January 2021

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Interferon-gamma-secreting cells in multiple sclerosis patients treated with interferon beta-1b

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7 January 2021

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Low levels of interferon-alpha induce CD86 (B7.2) expression and accelerates dendritic cell maturation from human peripheral blood mononuclear cells

1 reference

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7 January 2021

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IFN-beta differentially regulates CD40-induced cytokine secretion by human dendritic cells

1 reference

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Prostaglandin E(2) is a selective inducer of interleukin-12 p40 (IL-12p40) production and an inhibitor of bioactive IL-12p70 heterodimer

1 reference

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Interleukin (IL)-4 is a major regulatory cytokine governing bioactive IL-12 production by mouse and human dendritic cells

1 reference

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Interferon-beta differentially regulates expression of the IL-12 family members p35, p40, p19 and EBI3 in activated human dendritic cells

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Contrasting effect of alpha/beta- and gamma-interferons on expression of macrophage Ia antigens

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Interferon alpha/beta selectively antagonises down-regulation of mannosyl-fucosyl receptors on activated macrophages by interferon gamma

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Identifiers

10.1016/S1521-6616(03)00060-3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12804530%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12804530%20AND%20SRC:MED&resulttype=core&format=json

4 November 2019

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