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Mitochondria as Cell Targets of AZT (Zidovudine)
scientific article published on 01 October 1998
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scholarly article
1 reference
stated in
Europe PubMed Central
PubMed ID
9792211
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9792211%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
review article
1 reference
stated in
Europe PubMed Central
title
Mitochondria as cell targets of AZT (zidovudine)
(English)
1 reference
stated in
Europe PubMed Central
PubMed ID
9792211
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9792211%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
main subject
mitochondrion
1 reference
based on heuristic
inferred from title
zidovudine
1 reference
based on heuristic
inferred from title
author
Maria Barile
series ordinal
1
1 reference
stated in
Europe PubMed Central
PubMed ID
9792211
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9792211%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
Daniela Valenti
series ordinal
2
1 reference
stated in
Europe PubMed Central
PubMed ID
9792211
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9792211%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
author name string
E Quagliariello
series ordinal
3
1 reference
stated in
Europe PubMed Central
PubMed ID
9792211
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9792211%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
S Passarella
series ordinal
4
1 reference
stated in
Europe PubMed Central
PubMed ID
9792211
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9792211%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
publication date
1 October 1998
1 reference
stated in
Europe PubMed Central
PubMed ID
9792211
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9792211%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
published in
General Pharmacology
1 reference
stated in
Europe PubMed Central
PubMed ID
9792211
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9792211%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
volume
31
1 reference
stated in
Europe PubMed Central
PubMed ID
9792211
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9792211%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
issue
4
1 reference
stated in
Europe PubMed Central
PubMed ID
9792211
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9792211%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
page(s)
531-538
1 reference
stated in
Europe PubMed Central
PubMed ID
9792211
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9792211%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
cites work
Genotoxicity and mitochondrial damage in human lymphocytic cells chronically exposed to 3'-azido-2',3'-dideoxythymidine
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Depletion of muscle mitochondrial DNA in AIDS patients with zidovudine-induced myopathy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
AZT side effect on mitochondria does not depend on either inhibition of electron flow or mitochondrial uncoupling.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mechanisms of toxicity of 3'-azido-3'-deoxythymidine. Its interaction with adenylate kinase.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
3′-Azido-3′-deoxythymidine uptake into isolated rat liver mitochondria and impairment of ADP/ATP translocator
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The effect of zidovudine on skeletal muscle mtDNA in HIV-1 infected patients with mild or no muscle dysfunction.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Partial cytochrome c oxidase deficiency and cytoplasmic bodies in patients with zidovudine myopathy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Concurrent zidovudine-induced myopathy and hepatoxicity in patients treated for human immunodeficiency virus (HIV) infection
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Hepatic Morphological alterations induced by zidovudine (ZDV) in an experimental model
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Early features of zidovudine-associated myopathy: histopathological findings and clinical correlations
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mitochondrial myopathy caused by long-term zidovudine therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Zidovudine-induced mitochondrial myopathy is associated with muscle carnitine deficiency and lipid storage
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Efficient incorporation of anti-HIV deoxynucleotides by recombinant yeast mitochondrial DNA polymerase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Effects of 3'-azido-3'-deoxythymidine on the deoxynucleotide triphosphate pools of cultured human cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Massive conversion of guanosine to 8-hydroxy-guanosine in mouse liver mitochondrial DNA by administration of azidothymidine
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Major growth reduction and minor decrease in mitochondrial enzyme activity in cultured human muscle cells after exposure to zidovudine
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The Friend murine erythroleukemia cell, a model system for studying the association between bone marrow toxicity induced by 3'-azido-3'-dideoxythymidine and dideoxynucleoside inhibition of mtDNA replication
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cellular targets of 3'-azido-3'-deoxythymidine: an early (non-delayed) effect on oxidative phosphorylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The 5'-triphosphates of 3'-azido-3'-deoxythymidine and 2', 3'-dideoxynucleosides inhibit DNA polymerase gamma by different mechanisms
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ultrastructural changes associated with reduced mitochondrial DNA and impaired mitochondrial function in the presence of 2'3'-dideoxycytidine
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Cardiac mitochondrial DNA polymerase-gamma is inhibited competitively and noncompetitively by phosphorylated zidovudine
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The universality of bioenergetic disease and amelioration with redox therapy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Zidovudine myopathy: a distinctive disorder associated with mitochondrial dysfunction
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Strategies for antiviral therapy in AIDS.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
AZT causes tissue-specific inhibition of mitochondrial bioenergetic function.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Mitochondrial abnormalities in human immunodeficiency virus-associated myopathy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Massive hepatic steatosis and lactic acidosis in a patient with AIDS who was receiving zidovudine
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Ultrastructural characteristics and DNA immunocytochemistry in human immunodeficiency virus and zidovudine-associated myopathies
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The toxicity of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Nuclear and mitochondrial changes of co-cultivated spinal cord, spinal ganglia and muscle fibers following treatment with various doses of zidovudine
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Myopathies associated with human immunodeficiency virus and zidovudine: can their effects be distinguished?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Studies on the inhibition of mitochondrial DNA replication by 3'-azido-3'-deoxythymidine and other dideoxynucleoside analogs which inhibit HIV-1 replication
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Metabolic abnormalities in skeletal muscle of patients receiving zidovudine therapy observed by 31P in vivo magnetic resonance spectroscopy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Myopathy with human immunodeficiency virus type 1 (HIV-1) infection: HIV-1 or zidovudine?
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
AZT-induced mitochondrial myopathy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Zidovudine and dideoxynucleosides deplete wild-type mitochondrial DNA levels and increase deleted mitochondrial DNA levels in cultured Kearns-Sayre syndrome fibroblasts
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
31P magnetic resonance spectroscopy suggests impaired mitochondrial function in AZT-treated HIV-infected patients
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Administration of 3'-azido-3'-deoxythymidine, an inhibitor of HTLV-III/LAV replication, to patients with AIDS or AIDS-related complex
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS0306-3623%2898%2900041-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S0306-3623(98)00041-X
1 reference
stated in
Europe PubMed Central
PubMed ID
9792211
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9792211%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
PubMed ID
9792211
1 reference
stated in
Europe PubMed Central
PubMed ID
9792211
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9792211%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
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