(Q62819659)

English

A Novel Functional Epitope Formed by Domains 1 and 4 of the Human Common β-Subunit Is Involved in Receptor Activation by Granulocyte Macrophage Colony-stimulating Factor and Interleukin 5

scientific article published on 12 January 2003

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scholarly article

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Europe PubMed Central

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16 December 2019

A novel functional epitope formed by domains 1 and 4 of the human common beta-subunit is involved in receptor activation by granulocyte macrophage colony-stimulating factor and interleukin 5 (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12525483%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

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1 reference

based on heuristic

inferred from title

Colony stimulating factor 2

1 reference

based on heuristic

inferred from title

1

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16 December 2019

author name string

Sally C Ford

2

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16 December 2019

Ursula M Wiedemann

3

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16 December 2019

Paul D Carr

4

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16 December 2019

David L Ollis

5

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16 December 2019

Ian G Young

6

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16 December 2019

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12 January 2003

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16 December 2019

Journal of Biological Chemistry

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16 December 2019

278

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16 December 2019

10572-10577

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16 December 2019

12

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16 December 2019

Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model

1 reference

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IL-5-deficient mice have a developmental defect in CD5+ B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses.

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Blockade of collagen-induced arthritis post-onset by antibody to granulocyte-macrophage colony-stimulating factor (GM-CSF): requirement for GM-CSF in the effector phase of disease

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Granulocyte macrophage colony-stimulating factor: a new putative therapeutic target in multiple sclerosis.

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Cloning and expression of a gene encoding an interleukin 3 receptor-like protein: identification of another member of the cytokine receptor gene family

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Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor

1 reference

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21 January 2018

A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific α chain and a β chain shared with the receptor for GM-CSF

1 reference

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21 January 2018

Reconstitution of the functional receptors for murine and human interleukin 5

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21 January 2018

Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit

1 reference

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21 January 2018

JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region

1 reference

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21 January 2018

Granulocyte-macrophage colony-stimulating factor provokes RAS activation and transcription of c-fos through different modes of signaling.

1 reference

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21 January 2018

Definition of the role of tyrosine residues of the common beta subunit regulating multiple signaling pathways of granulocyte-macrophage colony-stimulating factor receptor

1 reference

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21 January 2018

Regulation of proliferation, differentiation and survival by the IL-3/IL-5/GM-CSF receptor family

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21 January 2018

Structural design and molecular evolution of a cytokine receptor superfamily

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21 January 2018

Multimeric cytokine receptors: common versus specific functions

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21 January 2018

Human growth hormone and extracellular domain of its receptor: crystal structure of the complex

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21 January 2018

Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A

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21 January 2018

Efficiency of signalling through cytokine receptors depends critically on receptor orientation

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21 January 2018

Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface

1 reference

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21 January 2018

A systematic mutational analysis of hormone-binding determinants in the human growth hormone receptor

1 reference

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21 January 2018

A hot spot of binding energy in a hormone-receptor interface

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21 January 2018

Identification of a critical ligand binding determinant of the human erythropoietin receptor. Evidence for common ligand binding motifs in the cytokine receptor family

1 reference

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21 January 2018

Shared and unique determinants of the erythropoietin (EPO) receptor are important for binding EPO and EPO mimetic peptide

1 reference

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21 January 2018

The high-affinity interaction of human IL-4 and the receptor alpha chain is constituted by two independent binding clusters

1 reference

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21 January 2018

Histidine-367 of the human common beta chain of the receptor is critical for high-affinity binding of human granulocyte-macrophage colony-stimulating factor.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M211664200

21 January 2018

A single tyrosine residue in the membrane-proximal domain of the granulocyte-macrophage colony-stimulating factor, interleukin (IL)-3, and IL-5 receptor common beta-chain is necessary and sufficient for high affinity binding and signaling by all thr

1 reference

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21 January 2018

Structure of the complete extracellular domain of the common beta subunit of the human GM-CSF, IL-3, and IL-5 receptors reveals a novel dimer configuration

1 reference

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21 January 2018

Expression, crystallization and derivatization of the complete extracellular domain of the beta(c) subunit of the human IL-5, IL-3 and GM-CSF receptors

1 reference

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21 January 2018

Development of a bicistronic vector driven by the human polypeptide chain elongation factor 1alpha promoter for creation of stable mammalian cell lines that express very high levels of recombinant proteins

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21 January 2018

Characterization of interleukin 5 receptors on eosinophilic sublines from human promyelocytic leukemia (HL-60) cells

1 reference

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21 January 2018

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21 January 2018

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

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21 January 2018

Molecular determinants of the granulocyte-macrophage colony-stimulating factor receptor complex assembly

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21 January 2018

Saturation mutagenesis of human interleukin-3.

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21 January 2018

Identification of receptor-binding domains on human interleukin 5 and design of an interleukin 5-derived receptor antagonist

1 reference

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21 January 2018

The structure, organization, activation and plasticity of the erythropoietin receptor

1 reference

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21 January 2018

Mutagenesis in the C-terminal region of human interleukin 5 reveals a central patch for receptor alpha chain recognition

1 reference

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High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis

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Identifiers

10.1074/JBC.M211664200

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12525483%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12525483%20AND%20SRC:MED&resulttype=core&format=json

16 December 2019

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