(Q64095096)

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Xanthohumol increases death receptor 5 expression and enhances apoptosis with the TNF-related apoptosis-inducing ligand in neuroblastoma cell lines

scientific article published on 14 March 2019

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29 April 2020

Xanthohumol increases death receptor 5 expression and enhances apoptosis with the TNF-related apoptosis-inducing ligand in neuroblastoma cell lines (English)

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29 April 2020

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Muthusamy Kunnimalaiyaan

5

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29 April 2020

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Samuel Engelsgjerd

1

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29 April 2020

Selvi Kunnimalaiyaan

2

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29 April 2020

Emad Kandil

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29 April 2020

T Clark Gamblin

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29 April 2020

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14 March 2019

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29 April 2020

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Europe PubMed Central

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29 April 2020

14

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29 April 2020

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29 April 2020

e0213776

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29 April 2020

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Creative Commons Attribution 4.0 International

14 March 2019

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April 2022 Public Data File from Crossref

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Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bcl-XL protects pancreatic adenocarcinoma cells against CD95- and TRAIL-receptor-mediated apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Sensitization for death receptor- or drug-induced apoptosis by re-expression of caspase-8 through demethylation or gene transfer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cell surface Death Receptor signaling in normal and cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

TRAIL triggers apoptosis in human malignant glioma cells through extrinsic and intrinsic pathways.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Restoration of TRAIL-induced apoptosis in a caspase-8-deficient neuroblastoma cell line by stable re-expression of caspase-8.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Drug-mediated sensitization to TRAIL-induced apoptosis in caspase-8-complemented neuroblastoma cells proceeds via activation of intrinsic and extrinsic pathways and caspase-dependent cleavage of XIAP, Bcl-xL and RIP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Emerging non-apoptotic functions of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/Apo2L.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A safety study of oral tangeretin and xanthohumol administration to laboratory mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contribution of epigenetic silencing of tumor necrosis factor-related apoptosis inducing ligand receptor 1 (DR4) to TRAIL resistance and ovarian cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiinvasive effect of xanthohumol, a prenylated chalcone present in hops (Humulus lupulus L.) and beer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Xanthohumol induces apoptosis in cultured 40-16 human colon cancer cells by activation of the death receptor- and mitochondrial pathway.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of the antiangiogenic activity by the hop flavonoid xanthohumol: NF-kappaB and Akt as targets

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Xanthohumol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Histone deacetylase inhibitors strongly sensitise neuroblastoma cells to TRAIL-induced apoptosis by a caspases-dependent increase of the pro- to anti-apoptotic proteins ratio.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tumor-derived mutations in the TRAIL receptor DR5 inhibit TRAIL signaling through the DR4 receptor by competing for ligand binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of PC-3 and DU145 prostate cancer cells by prenylflavonoids from hop (Humulus lupulus L.) induces a caspase-independent form of cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of Akt signaling by the lignan matairesinol sensitizes prostate cancer cells to TRAIL-induced apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Playing the DISC: turning on TRAIL death receptor-mediated apoptosis in cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Xanthohumol, a prenylated chalcone derived from hops, inhibits proliferation, migration and interleukin-8 expression of hepatocellular carcinoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Xanthohumol inhibits the neuroendocrine transcription factor achaete-scute complex-like 1, suppresses proliferation, and induces phosphorylated ERK1/2 in medullary thyroid cancer.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Xanthohumol feeding does not impair organ function and homoeostasis in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Targeting Notch pathway induces growth inhibition and differentiation of neuroblastoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Notch1 expression predicts an unfavorable prognosis and serves as a therapeutic target of patients with neuroblastoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growth inhibitory and apoptosis-inducing effects of xanthohumol, a prenylated chalone present in hops, in human prostate cancer cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of xanthohumol and metabolites in rats after oral and intravenous administration.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Xanthohumol lowers body weight and fasting plasma glucose in obese male Zucker fa/fa rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Peripheral neuroblastic tumors with genotype-phenotype discordance: a report from the Children's Oncology Group and the International Neuroblastoma Pathology Committee

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Xanthohumol impairs human prostate cancer cell growth and invasion and diminishes the incidence and progression of advanced tumors in TRAMP mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The radio-sensitizing effect of xanthohumol is mediated by STAT3 and EGFR suppression in doxorubicin-resistant MCF-7 human breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The mTOR signaling pathway in pediatric neuroblastoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The antitumor lignan Nortrachelogenin sensitizes prostate cancer cells to TRAIL-induced cell death by inhibition of the Akt pathway and growth factor signaling

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroblastoma of undifferentiated subtype, prognostic significance of prominent nucleolar formation, and MYC/MYCN protein expression: a report from the Children's Oncology Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Human pharmacokinetics of xanthohumol, an antihyperglycemic flavonoid from hops

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Neuroblastoma and MYCN

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Profiling and targeting of cellular bioenergetics: inhibition of pancreatic cancer cell proliferation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pharmacokinetics of prenylated hop phenols in women following oral administration of a standardized extract of hops.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Up-regulation of P21 inhibits TRAIL-mediated extrinsic apoptosis, contributing resistance to SAHA in acute myeloid leukemia cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-dependent prognostic effect by Mitosis-Karyorrhexis Index in neuroblastoma: a report from the Children's Oncology Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mechanisms of neuroblastoma regression

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Licochalcone-A induces intrinsic and extrinsic apoptosis via ERK1/2 and p38 phosphorylation-mediated TRAIL expression in head and neck squamous carcinoma FaDu cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

PI3King the lock: targeting the PI3K/Akt/mTOR pathway as a novel therapeutic strategy in neuroblastoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Survivors of childhood cancer in the United States: prevalence and burden of morbidity

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Xanthohumol-Mediated Suppression of Notch1 Signaling Is Associated with Antitumor Activity in Human Pancreatic Cancer Cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Xanthohumol inhibits Notch signaling and induces apoptosis in hepatocellular carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Augmented expression of MYC and/or MYCN protein defines highly aggressive MYC-driven neuroblastoma: a Children's Oncology Group study

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role for the PI3K/Akt/Nrf2 signaling pathway in the protective effects of carnosic acid against methylglyoxal-induced neurotoxicity in SH-SY5Y neuroblastoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antiproliferative and apoptotic effects of xanthohumol in cholangiocarcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Akt/mTOR pathway in cancer stem/progenitor cells is a potential therapeutic target for glioblastoma and neuroblastoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/30870485

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0213776

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30870485%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30870485%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30870485%20AND%20SRC:MED&resulttype=core&format=json

29 April 2020

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