(Q64252935)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30809156%20AND%20SRC:MED&resulttype=core&format=json

25 April 2020

title

The Pleiotropic Effects of GATA1 and KLF1 in Physiological Erythropoiesis and in Dyserythropoietic Disorders (English)

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25 April 2020

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Transcription Factors

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3

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25 April 2020

author name string

Gloria Barbarani

series ordinal

1

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25 April 2020

Cristina Fugazza

series ordinal

2

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25 April 2020

Antonella E Ronchi

series ordinal

4

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25 April 2020

language of work or name

English

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publication date

12 February 2019

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25 April 2020

published in

Frontiers in Physiology

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25 April 2020

volume

10

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25 April 2020

page(s)

91

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Creative Commons Attribution 4.0 International

25 April 2020

copyright license

start time

12 February 2019

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Delta-thalassemia caused by disruption of the site for an erythroid-specific transcription factor, GATA-1, in the delta-globin gene promoter

1 reference

12 December 2020

Congenital dyserythropoietic anaemia with novel intra-erythroblastic and intra-erythrocytic inclusions

1 reference

12 December 2020

Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1

1 reference

12 December 2020

Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy–negative individuals

1 reference

12 December 2020

A Novel, Erythroid Cell-Specific Murine Transcription Factor that Binds to the CACCC Element and is Related to the Krüppel Family of Nuclear Proteins†

1 reference

12 December 2020

Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene

1 reference

12 December 2020

Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF

1 reference

12 December 2020

Development of hematopoietic cells lacking transcription factor GATA-1

1 reference

12 December 2020

Analyses of beta-thalassemia mutant DNA interactions with erythroid Krüppel-like factor (EKLF), an erythroid cell-specific transcription factor

1 reference

12 December 2020

Alternative translation initiation site usage results in two functionally distinct forms of the GATA-1 transcription factor

1 reference

12 December 2020

A palindromic regulatory site within vertebrate GATA-1 promoters requires both zinc fingers of the GATA-1 DNA-binding domain for high-affinity interaction

1 reference

12 December 2020

Identification of a mutation in a GATA binding site of the platelet glycoprotein Ibbeta promoter resulting in the Bernard-Soulier syndrome

1 reference

12 December 2020

Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1

1 reference

12 December 2020

Isolation, genomic structure, and expression of human erythroid Krüppel-like factor (EKLF)

1 reference

12 December 2020

FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and megakaryocytic differentiation

1 reference

12 December 2020

A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development

1 reference

12 December 2020

Use of altered specificity mutants to probe a specific protein-protein interaction in differentiation: the GATA-1:FOG complex

1 reference

12 December 2020

Consequences of GATA-1 deficiency in megakaryocytes and platelets

1 reference

12 December 2020

Fetal expression of a human Agamma globin transgene rescues globin chain imbalance but not hemolysis in EKLF null mouse embryos

1 reference

12 December 2020

Familial dyserythropoietic anaemia and thrombocytopenia due to an inherited mutation in GATA1

1 reference

12 December 2020

A new PKLR gene mutation in the R-type promoter region affects the gene transcription causing pyruvate kinase deficiency

1 reference

12 December 2020

Uroporphyrinogen III synthase erythroid promoter mutations in adjacent GATA1 and CP2 elements cause congenital erythropoietic porphyria

1 reference

12 December 2020

Platelet characteristics in patients with X-linked macrothrombocytopenia because of a novel GATA1 mutation

1 reference

12 December 2020

The N-terminal zinc finger of the erythroid transcription factor GATA-1 binds GATC motifs in DNA.

1 reference

12 December 2020

X-linked thrombocytopenia caused by a novel mutation of GATA-1

1 reference

12 December 2020

Different substitutions at residue D218 of the X-linked transcription factor GATA1 lead to altered clinical severity of macrothrombocytopenia and anemia and are associated with variable skewed X inactivation

1 reference

12 December 2020

Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo

1 reference

12 December 2020

GATA-factor dependence of the multitype zinc-finger protein FOG-1 for its essential role in megakaryopoiesis

1 reference

12 December 2020

Development of myelofibrosis in mice genetically impaired for GATA-1 expression (GATA-1(low) mice).

1 reference

12 December 2020

Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome

1 reference

12 December 2020

X-linked thrombocytopenia with thalassemia from a mutation in the amino finger of GATA-1 affecting DNA binding rather than FOG-1 interaction

1 reference

12 December 2020

Mutagenesis of GATA1 is an initiating event in Down syndrome leukemogenesis

1 reference

12 December 2020

Mutations in exon 2 of GATA1 are early events in megakaryocytic malignancies associated with trisomy 21

1 reference

12 December 2020

Frequent mutations in the GATA-1 gene in the transient myeloproliferative disorder of Down syndrome

1 reference

12 December 2020

Natural history of GATA1 mutations in Down syndrome

1 reference

12 December 2020

Fetal origin of the GATA1 mutation in identical twins with transient myeloproliferative disorder and acute megakaryoblastic leukemia accompanying Down syndrome

1 reference

12 December 2020

Effects of the R216Q mutation of GATA-1 on erythropoiesis and megakaryocytopoiesis

1 reference

12 December 2020

GATA1 mutations in Down syndrome: implications for biology and diagnosis of children with transient myeloproliferative disorder and acute megakaryoblastic leukemia

1 reference

12 December 2020

Origins of leukaemia in children with Down syndrome

1 reference

12 December 2020

GATA1 function, a paradigm for transcription factors in hematopoiesis

1 reference

12 December 2020

Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1

1 reference

12 December 2020

Role of GATA-1 in normal and neoplastic hemopoiesis

1 reference

12 December 2020

A global role for EKLF in definitive and primitive erythropoiesis

1 reference

12 December 2020

GATA1 mutations in acute leukemia in children with Down syndrome

1 reference

12 December 2020

Major erythrocyte membrane protein genes in EKLF-deficient mice

1 reference

12 December 2020

An inherited mutation leading to production of only the short isoform of GATA-1 is associated with impaired erythropoiesis

1 reference

12 December 2020

Congenital erythropoietic porphyria due to a mutation in GATA1: the first trans-acting mutation causative for a human porphyria

1 reference

12 December 2020

Gata1 regulates dendritic-cell development and survival

1 reference

12 December 2020

Novel role for EKLF in megakaryocyte lineage commitment

1 reference

12 December 2020

Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders

1 reference

12 December 2020

A QTL influencing F cell production maps to a gene encoding a zinc-finger protein on chromosome 2p15.

1 reference

12 December 2020

Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia

1 reference

12 December 2020

Ablation of Gata1 in adult mice results in aplastic crisis, revealing its essential role in steady-state and stress erythropoiesis

1 reference

12 December 2020

Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in beta-thalassemia

1 reference

12 December 2020

Mutations in EKLF/KLF1 form the molecular basis of the rare blood group In(Lu) phenotype

1 reference

12 December 2020

Joining the loops: beta-globin gene regulation

1 reference

12 December 2020

Failure of terminal erythroid differentiation in EKLF-deficient mice is associated with cell cycle perturbation and reduced expression of E2F2.

1 reference

12 December 2020

Hereditary spherocytosis

1 reference

12 December 2020

Red cell membrane: past, present, and future

1 reference

12 December 2020

Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A.

1 reference

12 December 2020

EKLF/KLF1 controls cell cycle entry via direct regulation of E2f2.

1 reference

12 December 2020

Mutations affecting the secretory COPII coat component SEC23B cause congenital dyserythropoietic anemia type II.

1 reference

12 December 2020

Erythropoiesis: model systems, molecular regulators, and developmental programs

1 reference

12 December 2020

Congenital dyserythropoietic anemia type II (CDAII) is caused by mutations in the SEC23B gene.

1 reference

12 December 2020

A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium

1 reference

12 December 2020

Megakaryocyte-erythroid lineage promiscuity in EKLF null mouse blood

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12 December 2020

Preferential associations between co-regulated genes reveal a transcriptional interactome in erythroid cells

1 reference

12 December 2020

Dynamic regulation of Gata1 expression during the maturation of conventional dendritic cells.

1 reference

12 December 2020

KLF1 regulates BCL11A expression and γ- to β-globin gene switching

1 reference

12 December 2020

Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin

1 reference

12 December 2020

Mutation in erythroid specific transcription factor KLF1 causes Hereditary Spherocytosis in the Nan hemolytic anemia mouse model

1 reference

12 December 2020

Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Kruppel-like factor

1 reference

12 December 2020

Epigenetic modifications and human disease

1 reference

12 December 2020

A dominant mutation in the gene encoding the erythroid transcription factor KLF1 causes a congenital dyserythropoietic anemia

1 reference

12 December 2020

1 reference

12 December 2020

Single-lineage transcriptome analysis reveals key regulatory pathways in primitive erythroid progenitors in the mouse embryo

1 reference

12 December 2020

Compound heterozygosity for KLF1 mutations associated with remarkable increase of fetal hemoglobin and red cell protoporphyrin

1 reference

12 December 2020

Congenital dyserythropoietic anemias

1 reference

12 December 2020

Erythroid phenotypes associated with KLF1 mutations

1 reference

12 December 2020

Transcription factor networks in erythroid cell and megakaryocyte development

1 reference

12 December 2020

Structural and functional characterization of an atypical activation domain in erythroid Kruppel-like factor (EKLF)

1 reference

12 December 2020

Mutations in the second zinc finger of human EKLF reduce promoter affinity but give rise to benign and disease phenotypes.

1 reference

12 December 2020

KLF1 gene mutations cause borderline HbA(2)

1 reference

12 December 2020

From stem cell to red cell: regulation of erythropoiesis at multiple levels by multiple proteins, RNAs, and chromatin modifications

1 reference

12 December 2020

Ten novel mutations in the erythroid transcription factor KLF1 gene associated with increased fetal hemoglobin levels in adults

1 reference

12 December 2020

Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia

1 reference

12 December 2020

Molecular analysis of the rare in(Lu) blood type: toward decoding the phenotypic outcome of haploinsufficiency for the transcription factor KLF1.

1 reference

12 December 2020

Seventy-five genetic loci influencing the human red blood cell

1 reference

12 December 2020

A novel GATA1 mutation (Stop414Arg) in a family with the rare X-linked blood group Lu(a-b-) phenotype and mild macrothrombocytic thrombocytopenia

1 reference

12 December 2020

Erythroid transcription factor EKLF/KLF1 mutation causing congenital dyserythropoietic anemia type IV in a patient of Taiwanese origin: review of all reported cases and development of a clinical diagnostic paradigm.

1 reference

12 December 2020

Erythropoiesis: development and differentiation

1 reference

12 December 2020

Mutation of the GATA site in the erythroid cell-specific regulatory element of the ABO gene in a Bm subgroup individual

1 reference

12 December 2020

Ineffective erythropoiesis in β -thalassemia

1 reference

12 December 2020

Analysis of disease-causing GATA1 mutations in murine gene complementation systems

1 reference

12 December 2020

Identification of a novel erythroid-specific enhancer for the ALAS2 gene and its loss-of-function mutation which is associated with congenital sideroblastic anemia

1 reference

12 December 2020

Mapping cellular hierarchy by single-cell analysis of the cell surface repertoire

1 reference

12 December 2020

X-linked sideroblastic anemia due to ALAS2 intron 1 enhancer element GATA-binding site mutations

1 reference

12 December 2020

Ldb1 complexes: the new master regulators of erythroid gene transcription

1 reference

12 December 2020

Mutations in Kruppel-like factor 1 cause transfusion-dependent hemolytic anemia and persistence of embryonic globin gene expression.

1 reference

12 December 2020

Loss of GATA-1 full length as a cause of Diamond-Blackfan anemia phenotype

1 reference

12 December 2020

Primitive and definitive erythropoiesis in mammals

1 reference

12 December 2020

Determining lineage pathways from cellular barcoding experiments

1 reference

12 December 2020

Tight regulation of a timed nuclear import wave of EKLF by PKCθ and FOE during Pro-E to Baso-E transition.

1 reference

12 December 2020

No monkeying around: clonal tracking of stem cells and progenitors in the macaque

1 reference

12 December 2020

Rare hereditary red blood cell enzymopathies associated with hemolytic anemia - pathophysiology, clinical aspects, and laboratory diagnosis.

1 reference

12 December 2020

Recurrent GATA1 mutations in Diamond-Blackfan anaemia

1 reference

12 December 2020

Altered translation of GATA1 in Diamond-Blackfan anemia

1 reference

12 December 2020

Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis.

1 reference

12 December 2020

Congenital erythropoietic porphyria linked to GATA1-R216W mutation: challenges for diagnosis

1 reference

12 December 2020

A novel mutation of the GATA site in the erythroid cell-specific regulatory element of the ABO gene in a blood donor with the Am B phenotype

1 reference

12 December 2020

KLF1-null neonates display hydrops fetalis and a deranged erythroid transcriptome.

1 reference

12 December 2020

β-thalassemias: paradigmatic diseases for scientific discoveries and development of innovative therapies

1 reference

12 December 2020

Disorders of erythrocyte volume homeostasis

1 reference

12 December 2020

The biology of pediatric acute megakaryoblastic leukemia

1 reference

12 December 2020

Distinct routes of lineage development reshape the human blood hierarchy across ontogeny

1 reference

12 December 2020

Tracking erythroid progenitor cells in times of need and times of plenty

1 reference

12 December 2020

Advances in understanding erythropoiesis: evolving perspectives

1 reference

12 December 2020

Krüppeling erythropoiesis: an unexpected broad spectrum of human red blood cell disorders due to KLF1 variants

1 reference

12 December 2020

Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits

1 reference

12 December 2020

A single-cell resolution map of mouse hematopoietic stem and progenitor cell differentiation

1 reference

12 December 2020

EKLF/KLF1-regulated cell cycle exit is essential for erythroblast enucleation

1 reference

12 December 2020

Hematopoietic stem cell-independent hematopoiesis: emergence of erythroid, megakaryocyte, and myeloid potential in the mammalian embryo

1 reference

12 December 2020

Dyserythropoiesis of myelodysplastic syndromes

1 reference

12 December 2020

Characterization, regulation, and targeting of erythroid progenitors in normal and disordered human erythropoiesis

1 reference

12 December 2020

Studying hematopoiesis using single-cell technologies

1 reference

12 December 2020

Promiscuous DNA-binding of a mutant zinc finger protein corrupts the transcriptome and diminishes cell viability

1 reference

12 December 2020

Downregulation of GATA1 drives impaired hematopoiesis in primary myelofibrosis

1 reference

12 December 2020

An Unusual Hydrops Fetalis Associated with Compound Heterozygosity for Krüppel-like Factor 1 mutations

1 reference

12 December 2020

Molecular convergence in ex vivo models of Diamond-Blackfan anemia

1 reference

12 December 2020

Hematopoietic transcription factor mutations: important players in inherited platelet defects.

1 reference

12 December 2020

GATA1 erythroid-specific regulation of SEC23B expression and its implication in the pathogenesis of congenital dyserythropoietic anemia type II.

1 reference

12 December 2020

Global increase in replication fork speed during a p57KIP2-regulated erythroid cell fate switch

1 reference

12 December 2020

KLF1 drives the expression of fetal hemoglobin in British HPFH.

1 reference

12 December 2020

Polylox barcoding reveals haematopoietic stem cell fates realized in vivo

1 reference

12 December 2020

Transcriptional Heterogeneity and Lineage Commitment in Myeloid Progenitors

1 reference

12 December 2020

KLF1 E325K-associated Congenital Dyserythropoietic Anemia Type IV: Insights Into the Variable Clinical Severity

1 reference

12 December 2020

Clonal analysis of lineage fate in native haematopoiesis.

1 reference

12 December 2020

Population snapshots predict early haematopoietic and erythroid hierarchies.

1 reference

12 December 2020

The clinical spectrum of pyruvate kinase deficiency: data from the Pyruvate Kinase Deficiency Natural History Study.

1 reference

12 December 2020

Ribosome Levels Selectively Regulate Translation and Lineage Commitment in Human Hematopoiesis.

1 reference

12 December 2020

Causes and Consequences of Hematopoietic Stem Cell Heterogeneity.

1 reference

12 December 2020

Disruption of a GATA1-binding motif upstream of XG/PBDX abolishes Xga expression and resolves the Xg blood group system

1 reference

12 December 2020

Single-cell characterization of haematopoietic progenitors and their trajectories in homeostasis and perturbed haematopoiesis

1 reference

12 December 2020

Investigation of the variable In(Lu) phenotype caused by KLF1 variants

1 reference

12 December 2020

An update on the pathogenesis and diagnosis of Diamond-Blackfan anemia

1 reference

12 December 2020

Kinetics of adult hematopoietic stem cell differentiation in vivo

1 reference

12 December 2020

Identifiers

DOI

10.3389/FPHYS.2019.00091

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30809156%20AND%20SRC:MED&resulttype=core&format=json

25 April 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30809156%20AND%20SRC:MED&resulttype=core&format=json

25 April 2020

PubMed publication ID

30809156

1 reference