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Simultaneous inhibition of Rac1 and IKK pathways sensitizes lung cancer cells to TNFalpha-mediated apoptosis
scientific article published on 01 November 2001
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Europe PubMed Central
PubMed publication ID
11773980
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11773980%20AND%20SRC:MED&resulttype=core&format=json
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5 December 2019
title
Simultaneous inhibition of Rac1 and IKK pathways sensitizes lung cancer cells to TNFalpha-mediated apoptosis
(English)
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Europe PubMed Central
PubMed publication ID
11773980
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11773980%20AND%20SRC:MED&resulttype=core&format=json
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5 December 2019
main subject
lung cancer
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S Sanlioglu
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1
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Europe PubMed Central
PubMed publication ID
11773980
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11773980%20AND%20SRC:MED&resulttype=core&format=json
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5 December 2019
G Luleci
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2
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Europe PubMed Central
PubMed publication ID
11773980
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5 December 2019
K W Thomas
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3
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PubMed publication ID
11773980
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11773980%20AND%20SRC:MED&resulttype=core&format=json
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English
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publication date
1 November 2001
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PubMed publication ID
11773980
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retrieved
5 December 2019
published in
Cancer Gene Therapy
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Europe PubMed Central
PubMed publication ID
11773980
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11773980%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
volume
8
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Europe PubMed Central
PubMed publication ID
11773980
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11773980%20AND%20SRC:MED&resulttype=core&format=json
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5 December 2019
issue
11
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Europe PubMed Central
PubMed publication ID
11773980
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11773980%20AND%20SRC:MED&resulttype=core&format=json
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5 December 2019
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897-905
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Europe PubMed Central
PubMed publication ID
11773980
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11773980%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
exact match
https://scigraph.springernature.com/pub.10.1038/sj.cgt.7700394
0 references
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Mechanisms of apoptosis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
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7 January 2021
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Dicing with death: dissecting the components of the apoptosis machinery.
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
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7 January 2021
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Life, death, and the pursuit of apoptosis.
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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
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7 January 2021
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Apoptosis as a goal of cancer therapy
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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
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7 January 2021
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A new concept in neurodegeneration: TNFalpha is a silencer of survival signals
1 reference
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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
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7 January 2021
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RETRACTED: A new mechanism of neurodegeneration: a proinflammatory cytokine inhibits receptor signaling by a survival peptide
1 reference
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reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
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7 January 2021
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Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
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7 January 2021
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TNF-alpha activates at least two apoptotic signaling cascades
1 reference
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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
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7 January 2021
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An essential role for NF-kappaB in preventing TNF-alpha-induced cell death
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
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7 January 2021
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inferred from DOI database lookup
TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Suppression of TNF-alpha-induced apoptosis by NF-kappaB
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
retrieved
7 January 2021
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FADD/MORT1 is a common mediator of CD95 (Fas/APO-1) and tumor necrosis factor receptor-induced apoptosis
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
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7 January 2021
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TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
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7 January 2021
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inferred from DOI database lookup
The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
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7 January 2021
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The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
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7 January 2021
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IkappaBalpha gene transfer is cytotoxic to squamous-cell lung cancer cells and sensitizes them to tumor necrosis factor-alpha-mediated cell death.
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
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7 January 2021
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inferred from DOI database lookup
A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB
1 reference
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Crossref
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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
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7 January 2021
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inferred from DOI database lookup
NF-kappaB activation: the I kappaB kinase revealed?
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
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7 January 2021
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inferred from DOI database lookup
Identification and characterization of an IkappaB kinase
1 reference
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https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
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7 January 2021
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Bridging the gap: composition, regulation, and physiological function of the IkappaB kinase complex
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
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7 January 2021
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inferred from DOI database lookup
The I kappa B kinase (IKK) complex is tripartite and contains IKK gamma but not IKAP as a regular component.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
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7 January 2021
based on heuristic
inferred from DOI database lookup
Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
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7 January 2021
based on heuristic
inferred from DOI database lookup
Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Severe liver degeneration in mice lacking the IkappaB kinase 2 gene
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
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7 January 2021
based on heuristic
inferred from DOI database lookup
Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
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7 January 2021
based on heuristic
inferred from DOI database lookup
Protection from reoxygenation injury by inhibition of rac1.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
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7 January 2021
based on heuristic
inferred from DOI database lookup
rac1 regulates a cytokine-stimulated, redox-dependent pathway necessary for NF-kappaB activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
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7 January 2021
based on heuristic
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A simple method for the rapid generation of recombinant adenovirus vectors
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
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7 January 2021
based on heuristic
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Direct gene transfer of human CFTR into human bronchial epithelia of xenografts with E1-deleted adenoviruses.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
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7 January 2021
based on heuristic
inferred from DOI database lookup
Expression of the cystic fibrosis gene in adult human lung
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
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7 January 2021
based on heuristic
inferred from DOI database lookup
Safety of airway gene transfer with Ad2/CFTR2: aerosol administration in the nonhuman primate
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
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7 January 2021
based on heuristic
inferred from DOI database lookup
A phase I study of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator gene to a lung segment of individuals with cystic fibrosis
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
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7 January 2021
based on heuristic
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Gene therapy of cystic fibrosis lung disease using E1 deleted adenoviruses: a phase I trial
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
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7 January 2021
based on heuristic
inferred from DOI database lookup
Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inefficient gene transfer by adenovirus vector to cystic fibrosis airway epithelia of mice and humans
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Modification of the genetic program of human alveolar macrophages by adenovirus vectors in vitro is feasible but inefficient, limited in part by the low level of expression of the coxsackie/adenovirus receptor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Recombinant E1-deleted adenovirus vector induces apoptosis in two lung cancer cell lines
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rac1 inhibits TNF-alpha-induced endothelial cell apoptosis: dual regulation by reactive oxygen species
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Systematic analysis of repeated gene delivery into animal lungs with a recombinant adenovirus vector
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Prolonged transgene expression in cotton rat lung with recombinant adenoviruses defective in E2a.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Limited entry of adenovirus vectors into well-differentiated airway epithelium is responsible for inefficient gene transfer
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Basolateral localization of fiber receptors limits adenovirus infection from the apical surface of airway epithelia.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Lack of high affinity fiber receptor activity explains the resistance of ciliated airway epithelia to adenovirus infection
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
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7 January 2021
based on heuristic
inferred from DOI database lookup
Coxsackievirus-adenovirus receptor expression in ovarian cancer cell lines is associated with increased adenovirus transduction efficiency and transgene expression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
TNF-alpha stimulates caspase-3 activation and apoptotic cell death in primary septo-hippocampal cultures.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of the DNA binding activity of NF-kappa B.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of nuclear transcription factor NF-kappaB by interleukin-1 is accompanied by casein kinase II-mediated phosphorylation of the p65 subunit
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The p38 mitogen-activated protein kinase is required for NF-kappaB-dependent gene expression. The role of TATA-binding protein (TBP)
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Association between proto-oncoprotein Rel and TATA-binding protein mediates transcriptional activation by NF-kappa B.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Rac1 regulates interleukin 1-induced nuclear factor kappaB activation in an inhibitory protein kappaBalpha-independent manner by enhancing the ability of the p65 subunit to transactivate gene expression
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanism
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1038%2FSJ.CGT.7700394
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1038/SJ.CGT.7700394
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11773980
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11773980%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
PubMed publication ID
11773980
1 reference
stated in
Europe PubMed Central
PubMed publication ID
11773980
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11773980%20AND%20SRC:MED&resulttype=core&format=json
retrieved
5 December 2019
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