(Q6589190)

Periplasmic binding protein-like I

1 reference

GPCR, family 3, nine cysteines domain superfamily

1 reference

Receptor, ligand binding region, protein family

1 reference

GPCR family 3, C-terminal domain, protein family

1 reference

GPCR, family 3, nine cysteines domain, protein family

1 reference

Metabotropic glutamate receptor, Homer-binding domain, protein family

1 reference

GPCR, family 3, conserved site, protein family

1 reference

glutamate receptor activity

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

25 April 2017

Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P41594

G protein-coupled receptor activity

IDA

3 references

8 April 2019

Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41594

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41594

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41594

signal transducer activity

1 reference

25 April 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P41594

G protein-coupled receptor activity involved in regulation of postsynaptic membrane potential

1 reference

25 April 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P41594

neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration

1 reference

25 April 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P41594

3 references

8 April 2019

A Novel Human CAMK2A Mutation Disrupts Dendritic Morphology and Synaptic Transmission, and Causes ASD-Related Behaviors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41594

8 April 2019

The association of metabotropic glutamate receptor type 5 with the neuronal Ca2+-binding protein 2 modulates receptor function

GOA

curator

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41594

8 April 2019

Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41594

protein tyrosine kinase activator activity

IPI

1 reference

8 April 2019

Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41594

protein tyrosine kinase binding

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41594

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41594

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41594

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

extracellular exosome

1 reference

25 April 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P41594

1 reference

25 April 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P41594

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41594

1 reference

25 April 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P41594

integral component of plasma membrane

3 references

8 April 2019

Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41594

8 April 2019

Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41594

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41594

Schaffer collateral - CA1 synapse

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41594

postsynaptic density membrane

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41594

phospholipase C-activating G protein-coupled glutamate receptor signaling pathway

biological process

1 reference

8 April 2019

Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41594

G protein-coupled glutamate receptor signaling pathway

1 reference

25 April 2017

Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P41594

G protein-coupled receptor signaling pathway

IMP

regulation of long-term neuronal synaptic plasticity

2 references

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41594

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41594

1 reference

8 April 2019

Analysis of copy number variation in Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41594

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41594

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41594

chemical synaptic transmission

1 reference

8 April 2019

Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41594

regulation of synaptic transmission, glutamatergic

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41594

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

1 reference

25 April 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P41594

regulation of postsynaptic membrane potential

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41594

regulation of postsynaptic cytosolic calcium ion concentration

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41594

regulation of protein phosphorylation

1 reference

8 April 2019

Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41594

regulation of translation

IGI

1 reference

8 April 2019

Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41594

regulation of translational elongation

1 reference

8 April 2019

Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41594

G protein-coupled glutamate receptor signaling pathway

IGI

postsynaptic modulation of chemical synaptic transmission

IMP

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41594

trans-synaptic signaling by endocannabinoid, modulating synaptic transmission

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41594

regulation of intracellular calcium activated chloride channel activity

1 reference

8 April 2019

Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41594

cellular response to amyloid-beta

IGI

physically interacts with

1 reference

1417

17 August 2016

1 reference

6409

17 August 2016

1 reference

6452

17 August 2016

2 references

1434

English

17 August 2016

1433

English

6-methyl-2-(phenylethynyl)pyridine

17 August 2016

has use

allosteric modulator

1 reference

1426

17 August 2016

1 reference

3336

17 August 2016

1 reference

1420

17 August 2016

1 reference

1422

17 August 2016

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3301626

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2346738

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3545036

Gene Atlas image

PBB GE GRM5 207235 s at fs.png
732 × 530; 12 KB

0 references

has part(s)

GPCR, family 3, nine cysteines domain

1 reference

Receptor, ligand binding region

1 reference

GPCR, family 3, conserved site

1 reference

GPCR family 3, C-terminal

1 reference

Metabotropic glutamate receptor, Homer-binding domain

1 reference

D12.776.543.750.695.450.500

Identifiers

MeSH descriptor ID

D064529

subject named as

Receptor, Metabotropic Glutamate 5

0 references

MeSH tree code

0 references

D12.776.543.750.720.200.450.500.500

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

0 references

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

1 reference

5 August 2016

inferred by common MeSH mappings on source and on Wikidata

1 reference

UMLS 2023