(Q6594108)

English

Nemo like kinase

mammalian protein found in Homo sapiens

Nemo-like kinase
Protein LAK1
NLK
serine/threonine-protein kinase NLK

In more languages

Statements

1 reference

13 November 2019

UniProt protein ID

0 references

Protein kinase-like domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q9UBE8

Protein kinase domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Mitogen-activated protein (MAP) kinase, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Protein kinase, ATP binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

Serine/threonine-protein kinase, active site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

transferase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

nucleotide binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

transcription factor binding

determination method

metal ion binding

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

kinase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

protein binding

determination method

9 references

8 April 2019

The protein interaction landscape of the human CMGC kinase group

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

8 April 2019

Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

8 April 2019

Next-generation sequencing to generate interactome datasets

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

8 April 2019

A proteome-scale map of the human interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

8 April 2019

Zipper-interacting protein kinase (ZIPK) modulates canonical Wnt/beta-catenin signaling through interaction with Nemo-like kinase and T-cell factor 4 (NLK/TCF4)

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

8 April 2019

Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

8 April 2019

STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

8 April 2019

Widespread macromolecular interaction perturbations in human genetic disorders

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

8 April 2019

Toward an understanding of the protein interaction network of the human liver

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

ubiquitin protein ligase binding

determination method

1 reference

8 April 2019

NARF, an nemo-like kinase (NLK)-associated ring finger protein regulates the ubiquitylation and degradation of T cell factor/lymphoid enhancer factor (TCF/LEF)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

protein serine/threonine kinase activity

determination method

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

protein kinase activity

determination method

3 references

8 April 2019

Characterization of the Fugu rubripes NLK and FN5 genes flanking the NF1 (Neurofibromatosis type 1) gene in the 5' direction and mapping of the human counterparts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

MAP kinase activity

determination method

5 references

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBE8&geneProductId=UniProtKB:Q9UBE8

determination method

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBE8&geneProductId=UniProtKB:Q9UBE8

determination method

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBE8&geneProductId=UniProtKB:Q9UBE8

determination method

24 April 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBE8&geneProductId=UniProtKB:Q9UBE8

determination method

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBE8&geneProductId=UniProtKB:Q9UBE8

determination method

MAP kinase activity

determination method

4 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

determination method

5 references

8 April 2019

Nlk is a murine protein kinase related to Erk/MAP kinases and localized in the nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

biological process

phosphorylation

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

protein stabilization

determination method

1 reference

8 April 2019

Stabilization of ATF5 by TAK1-Nemo-like kinase critically regulates the interleukin-1β-stimulated C/EBP signaling pathway

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

Wnt signaling pathway

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

transcription, DNA-templated

determination method

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q9UBE8&geneProductId=UniProtKB:Q9UBE8

determination method

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

protein autophosphorylation

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

transforming growth factor beta receptor signaling pathway

determination method

1 reference

8 April 2019

Role of the TAK1-NLK-STAT3 pathway in TGF-beta-mediated mesoderm induction

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

Wnt signaling pathway, calcium modulating pathway

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

regulation of gene expression

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q9UBE8

determination method

intracellular signal transduction

determination method

3 references

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

1 reference

Ensembl protein ID

ENSP00000384625

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000384625

ENSP00000433117

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000433117

ENSP00000464656

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000464656

1 reference

Freebase Data Dumps

publication date

28 October 2013

Sitelinks

Wikipedia(4 entries)

enwiki NLK
ptwiki NLK
shwiki NLK (kinaza)
srwiki NLK (kinaza)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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