(Q67289025)

English

The reaction of trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene with DNA involves attack at the N7-position of guanine moieties

scientific article published on 01 January 1978

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11 September 2019

The reaction of trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene with DNA involves attack at the N7-position of guanine moieties (English)

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11 September 2019

author name string

M. R. Osborne

1

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16 July 2022

R. G. Harvey

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16 July 2022

P. Brookes

3

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16 July 2022

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16 July 2022

publication date

1 January 1978

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11 September 2019

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21 August 2023

Chemico-biological Interactions

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11 September 2019

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11 September 2019

123-130

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11 September 2019

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11 September 2019

Metabolic activation of benzo(a)pyrene proceeds by a diol-epoxide

1

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Exceptional mutagenicity of a benzo[a]pyrene diol epoxide in cultured mammalian cells

3

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Identification of mutagenic metabolites of benzo(a)pyrene in mammalian cells

4

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High mutagenicity and toxicity of a diol epoxide derived from benzo(a)pyrene

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Mutagenicity and cytotoxicity of benzo(a)pyrene benzo-ring epoxides

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Benzo[a]pyrene 7,8-dihydrodiol is more carcinogenic than benzo[a]pyrene in newborn mice

7

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Tumour-initiating activities on mouse skin of dihydrodiols derived from benzo[a]pyrene

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21 August 2023

The reaction of (±)-7α, 8β-dihydroxy-9β, 10β-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene with dna

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Letter: Benzo[a]pyrene-nucleic acid derivative found in vivo: structure of a benzo[a]pyrenetetrahydrodiol epoxide-guanosine adduct

11

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21 August 2023

Alkylation of polyguanylic acid at the 2-amino group and phosphate by the potent mutagen (+/-)-7beta,8alpha-dihydroxy-9beta,10beta-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene

12

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Isolation of the hydrocarbon-deoxyribonucleoside products from the DNA of mouse embryo cells treated in culture with 7-methylbenz(a)anthracene-3H

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Nucleoside adducts from the in vitro reaction of benzo[a]pyrene-7,8-dihydrodiol 9,10-oxide or benzo[a]pyrene 4,5-oxide with nucleic acids

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Alkylation by propylene oxide of deoxyribonucleic acid, adenine, guanosine and deoxyguanylic acid

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Aflatoxin B -oxide generated by chemical or enzymic oxidation of aflatoxin B1 causes guanine substitution in nucleic acids

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21 August 2023

On the nature of the product which results when 7,8-dihydro-7,8-dihydroxybenzo(a)pyrene is metabolised in vitro and bound to DNA.

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Novel assay of 7-alkylation of guanine residues in DNA. Application to nitrogen mustard, triethylenemelamine and mitomycin C

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The isomeric 9,10-oxides of trans-7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene

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Application of the change in partition coefficient with pH to the structure determination of alkyl substituted guanosines

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Reaction of 7-bromomethylbenz[a]anthracene with nucleic acids, polynucleotides, and nucleosides

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The conversion of benzo[a]pyrene 4,5-oxide into 4-hydroxybenzo[a]pyrene in the presence of polyriboguanylic acid

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The interaction of the 7,8-dihydrodiol-9, 10-oxides of benzo(a)pyrene with bacteriophages R17 and T7

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Identifiers

10.1016/0009-2797(78)90087-X

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:630642%20AND%20SRC:MED&resulttype=core&format=json

11 September 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:630642%20AND%20SRC:MED&resulttype=core&format=json

11 September 2019

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