(Q67593704)

English

The disposition of valproate and its metabolites in the late first trimester and early second trimester of pregnancy in maternal serum, urine, and amniotic fluid: effect of dose, co-medication, and the presence of spina bifida

scientific article published on 01 January 1992

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scholarly article

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1451717%20AND%20SRC:MED&resulttype=core&format=json

15 September 2019

The disposition of valproate and its metabolites in the late first trimester and early second trimester of pregnancy in maternal serum, urine, and amniotic fluid: effect of dose, co-medication, and the presence of spina bifida (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1451717%20AND%20SRC:MED&resulttype=core&format=json

15 September 2019

1 reference

based on heuristic

inferred from title

5

1 reference

Europe PubMed Central

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15 September 2019

author name string

J G Omtzigt

1

1 reference

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15 September 2019

H Nau

2

1 reference

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15 September 2019

F J Los

3

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1451717%20AND%20SRC:MED&resulttype=core&format=json

15 September 2019

L Pijpers

4

1 reference

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15 September 2019

publication date

1 January 1992

1 reference

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15 September 2019

European Journal of Clinical Pharmacology

1 reference

Europe PubMed Central

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15 September 2019

43

1 reference

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15 September 2019

4

1 reference

Europe PubMed Central

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15 September 2019

381-388

1 reference

Europe PubMed Central

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15 September 2019

https://scigraph.springernature.com/pub.10.1007/bf02220613

0 references

Serum protein binding of valproic acid in fetus-mother pairs throughout pregnancy: correlation with oxytocin administration and albumin and free fatty acid concentrations

1 reference

https://pubmed.ncbi.nlm.nih.gov/1451717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Quantitative determination of valproic acid and 14 metabolites in serum and urine by gas chromatography/mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/1451717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aspects of the metabolism of valproic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/1451717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Valproic acid teratogenicity in mice after various administration and phenobarbital-pretreatment regimens: the parent drug and not one of the metabolites assayed is implicated as teratogen

1 reference

https://pubmed.ncbi.nlm.nih.gov/1451717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Valproic acid and its metabolites: placental transfer, neonatal pharmacokinetics, transfer via mother's milk and clinical status in neonates of epileptic mothers.

1 reference

https://pubmed.ncbi.nlm.nih.gov/1451717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Urinary excretion of valproate and some metabolites in chronically treated patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/1451717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Materno-fetal pharmacokinetics and fetal distribution of valproic acid in a pregnant rhesus monkey

1 reference

https://pubmed.ncbi.nlm.nih.gov/1451717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Valproic acid teratogenicity: demonstration that the biochemical mechanism differs from that of valproate hepatotoxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/1451717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Valproic Acid and Metabolites: Pharmacological and Toxicological Studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/1451717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Placental transfer and neonatal elimination of mono-unsaturated metabolites of valproic acid

1 reference

https://pubmed.ncbi.nlm.nih.gov/1451717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Valproate: a new cause of birth defects--report from Italy and follow-up from France

1 reference

https://pubmed.ncbi.nlm.nih.gov/1451717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of aspirin on valproic acid metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/1451717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Valproic acid in the perinatal period: decreased maternal serum protein binding results in fetal accumulation and neonatal displacement of the drug and some metabolites

1 reference

https://pubmed.ncbi.nlm.nih.gov/1451717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Spina bifida and in-utero exposure to valproate

1 reference

https://pubmed.ncbi.nlm.nih.gov/1451717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of valproic acid by hepatic microsomal cytochrome P-450

1 reference

https://pubmed.ncbi.nlm.nih.gov/1451717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Maternal valproic acid and congenital neural tube defects

1 reference

https://pubmed.ncbi.nlm.nih.gov/1451717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Valproate hydroxylation by human fetal tissues and embryotoxicity of metabolites.

1 reference

https://pubmed.ncbi.nlm.nih.gov/1451717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The risk of spina bifida aperta after first-trimester exposure to valproate in a prenatal cohort

1 reference

https://pubmed.ncbi.nlm.nih.gov/1451717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clinical pharmacokinetics of valproic acid--1988.

1 reference

https://pubmed.ncbi.nlm.nih.gov/1451717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential transplacental binding of valproic acid: influence of free fatty acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/1451717

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF02220613

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1451717%20AND%20SRC:MED&resulttype=core&format=json

15 September 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1451717%20AND%20SRC:MED&resulttype=core&format=json

15 September 2019

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