(Q67595376)

English

Importance of "first-pass elimination" for interindividual differences in steady-state concentrations of the adrenergic beta-receptor antagonist alprenolol

scientific article published on 01 June 1977

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scholarly article

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:881641%20AND%20SRC:MED&resulttype=core&format=json

15 September 2019

Importance of "first-pass elimination" for interindividual differences in steady-state concentrations of the adrenergic beta-receptor antagonist alprenolol (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:881641%20AND%20SRC:MED&resulttype=core&format=json

15 September 2019

author name string

G. Alván

1

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A881641

4 August 2022

M. Lind

2

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A881641

4 August 2022

B. Mellström

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A881641

4 August 2022

C. von Bahr

4

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A881641

4 August 2022

language of work or name

1 reference

National Center for Biotechnology Information

PubMed publication ID

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&retmode=json&id=881641

4 August 2022

publication date

1 June 1977

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:881641%20AND%20SRC:MED&resulttype=core&format=json

15 September 2019

Journal of Pharmacokinetics and Pharmacodynamics

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:881641%20AND%20SRC:MED&resulttype=core&format=json

15 September 2019

5

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:881641%20AND%20SRC:MED&resulttype=core&format=json

15 September 2019

3

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:881641%20AND%20SRC:MED&resulttype=core&format=json

15 September 2019

193-205

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:881641%20AND%20SRC:MED&resulttype=core&format=json

15 September 2019

https://scigraph.springernature.com/pub.10.1007/bf01065395

0 references

Clearance and biologic half-life as indices of intrinsic hepatic metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/881641

12 December 2020

based on heuristic

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Influence of the route of administration on the area under the plasma concentration-time curve

1 reference

https://pubmed.ncbi.nlm.nih.gov/881641

12 December 2020

based on heuristic

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First pass hydroxylation of nortriptyline: concentrations of parent drug and major metabolites in plasma

1 reference

https://pubmed.ncbi.nlm.nih.gov/881641

12 December 2020

based on heuristic

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Plasma propranolol levels in adults With observations in four children

1 reference

https://pubmed.ncbi.nlm.nih.gov/881641

12 December 2020

based on heuristic

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Steady-state plasma concentrations of alprenolol in man

1 reference

https://pubmed.ncbi.nlm.nih.gov/881641

12 December 2020

based on heuristic

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Disposition of propranolol. V. Drug accumulation and steady-state concentrations during chronic oral administration in man.

1 reference

https://pubmed.ncbi.nlm.nih.gov/881641

12 December 2020

based on heuristic

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Proceedings: "First-pass" effect and dose dependent availability as factors contributing to interindividual differences in equilibrium concentrations of alprenolol in man

1 reference

https://pubmed.ncbi.nlm.nih.gov/881641

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of route of administration on drug availability

1 reference

https://pubmed.ncbi.nlm.nih.gov/881641

12 December 2020

based on heuristic

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Relationship between dose and plateau levels of drugs eliminated by parallel first-order and capacity-limited kinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/881641

12 December 2020

based on heuristic

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Stoichiometric interaction of a beta-receptor blocking drug with fraction of liver cytochrome P-450 as a possible cause for its dose-dependent availability

1 reference

https://pubmed.ncbi.nlm.nih.gov/881641

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Influence of First-Pass Effect on Availability of Drugs on Oral Administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/881641

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased clearance of antipyrine and d-propranolol after phenobarbital treatment in the monkey. Relative contributions of enzyme induction and increased hepatic blood flow

1 reference

https://pubmed.ncbi.nlm.nih.gov/881641

12 December 2020

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Transport and Binding of Methotrexate In Vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/881641

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The disposition of propranolol. I. Elimination during oral absorption in man

1 reference

https://pubmed.ncbi.nlm.nih.gov/881641

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combined pharmacokinetic and pharmacodynamic studies on alprenolol and 4-hydroxy-alprenolol in man.

1 reference

https://pubmed.ncbi.nlm.nih.gov/881641

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clearance concepts in pharmacokinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/881641

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Possible Role of Cytochrome P-450 in the Liver “First Pass Elimination” of a P-Receptor Blocking Drug

1 reference

https://pubmed.ncbi.nlm.nih.gov/881641

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of route of administration on drug disposition

1 reference

https://pubmed.ncbi.nlm.nih.gov/881641

12 December 2020

based on heuristic

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Gas chromatographic determination of the secondary amine alprenolol, as its trifluoroacetyl derivative, at nanogram levels in biological fluids

1 reference

https://pubmed.ncbi.nlm.nih.gov/881641

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Physiological and Pharmacokinetic Complexities in Bioavailability Testing

1 reference

https://pubmed.ncbi.nlm.nih.gov/881641

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Absorption of alprenolol in man from tablets with different rates of release

1 reference

https://pubmed.ncbi.nlm.nih.gov/881641

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prediction of systemic availability from plasma-level data after oral drug administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/881641

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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