(Q67748581)

English

Polypeptide halomethyl ketones bind to serine proteases as analogs of the tetrahedral intermediate. X-ray crystallographic comparison of lysine- and phenylalanine-polypeptide chloromethyl ketone-inhibited subtilisin

scientific article published on February 25, 1976

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1249069%20AND%20SRC:MED&resulttype=core&format=json

17 September 2019

Polypeptide halomethyl ketones bind to serine proteases as analogs of the tetrahedral intermediate. X-ray crystallographic comparison of lysine- and phenylalanine-polypeptide chloromethyl ketone-inhibited subtilisin (English)

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17 September 2019

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5 September 2022

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10.1016/S0021-9258(17)33806-1

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8 November 2023

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8 November 2023

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T. L. Poulos

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5 September 2022

R. A. Alden

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5 September 2022

S. T. Freer

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5 September 2022

J. J. Birktoft

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5 September 2022

J. Kraut

5

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5 September 2022

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1 February 1976

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17 September 2019

25 February 1976

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National Center for Biotechnology Information

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5 September 2022

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http://intl.jbc.org/cgi/content/abstract/251/4/1097

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5 September 2022

https://doi.org/10.1016/s0021-9258(17)33806-1

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8 November 2023

https://api.elsevier.com/content/article/PII:S0021925817338061?httpAccept=text/xml

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8 November 2023

https://api.elsevier.com/content/article/PII:S0021925817338061?httpAccept=text/plain

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8 November 2023

Journal of Biological Chemistry

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17 September 2019

251

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17 September 2019

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17 September 2019

1097-1103

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1249069%20AND%20SRC:MED&resulttype=core&format=json

17 September 2019

On the identity of subtilisins BPN' and novo

2

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10.1016/S0021-9258(17)33806-1

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8 November 2023

Identification of histidine 64 in the active site of subtilisin

3

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10.1016/S0021-9258(17)33806-1

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8 November 2023

An x-ray crystallographic study of the binding of peptide chloromethyl ketone inhibitors to subtilisin BPN'

4

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10.1016/S0021-9258(17)33806-1

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8 November 2023

Comparison of the active site stereochemistry and substrate conformation in α-chymotrypsin and subtilisin BPN′

5

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10.1016/S0021-9258(17)33806-1

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8 November 2023

Crystal structure of a subtilisin BPN′ complex with N-benzoyl-l-arginine

6

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10.1016/S0021-9258(17)33806-1

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8 November 2023

Subtilisin. Stereochemical mechanism involving transition-state stabilization

7

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10.1016/S0021-9258(17)33806-1

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8 November 2023

Affinity labelling of proteinases with tryptic specificity by peptides with C-terminal lysine chloromethyl ketone

8

1 reference

10.1016/S0021-9258(17)33806-1

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8 November 2023

Use of peptide aldehydes to generate transition-state analogs of elastase

10

1 reference

10.1016/S0021-9258(17)33806-1

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8 November 2023

Chromatography and activity of thiol-subtilisin.

12

1 reference

10.1016/S0021-9258(17)33806-1

https://api.crossref.org/works/10.1016/S0021-9258(17)33806-1

8 November 2023

Structure of Subtilisin BPN′ at 2.5 Å Resolution

13

1 reference

10.1016/S0021-9258(17)33806-1

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8 November 2023

Atomic coordinates for subtilisin BPN′ (or Novo)

16

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10.1016/S0021-9258(17)33806-1

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8 November 2023

Structure and specific binding of trypsin: comparison of inhibited derivatives and a model for substrate binding

18

1 reference

10.1016/S0021-9258(17)33806-1

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8 November 2023

Effect of secondary interaction on the enzymatic activity of subtilisin BPN′: Comparison with α-chymotrypsin, trypsin, and elastase

19

1 reference

10.1016/S0021-9258(17)33806-1

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8 November 2023

Comparative study of various serine alkaline proteinases from microorganisms. Esterase activity against N-acylated peptide ester substrates

20

1 reference

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8 November 2023

Structure of the complex formed by bovine trypsin and bovine pancreatic trypsin inhibitor. Crystal structure determination and stereochemistry of the contact region

22

1 reference

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8 November 2023

Crystal structure of the complex of porcine trypsin with soybean trypsin inhibitor (Kunitz) at 2.6 Å resolution

23

1 reference

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8 November 2023

Substrate binding site in bovine chymotrypsin Aγ. Crystallographic study using peptide chloromethyl ketones as site-specific inhibitors

24

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8 November 2023

ROLE OF SERINE IN CHYMOTRYPSIN ACTION. CONVERSION OF THE ACTIVE SERINE TO DEHYDROALANINE

25

1 reference

10.1016/S0021-9258(17)33806-1

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8 November 2023

The formation of anhydrochymotrypsin by removing the elements of water from the serine at the active site

26

1 reference

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8 November 2023

Studies on the Reaction of Chymotrypsin and L-1-Chloro-3-tosylamido-4-phenyl-2-butanone

27

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8 November 2023

The reactivity of his-57 in chymotrypsin to alkylation

28

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8 November 2023

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1249069%20AND%20SRC:MED&resulttype=core&format=json

17 September 2019

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