(Q67852255)

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The role of insulin receptor kinase domain autophosphorylation in receptor-mediated activities. Analysis with insulin and anti-receptor antibodies

scientific article published on 01 July 1992

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18 September 2019

The role of insulin receptor kinase domain autophosphorylation in receptor-mediated activities. Analysis with insulin and anti-receptor antibodies (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1320027%20AND%20SRC:MED&resulttype=core&format=json

18 September 2019

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10.1016/S0021-9258(18)42273-9

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6 December 2023

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6 December 2023

author name string

P. A. Wilden

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13 September 2022

K. Siddle

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13 September 2022

E. Haring

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13 September 2022

J. M. Backer

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13 September 2022

M. F. White

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13 September 2022

C. R. Kahn

6

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13 September 2022

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1 July 1992

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18 September 2019

5 July 1992

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13 September 2022

full work available at URL

http://intl.jbc.org/cgi/content/abstract/267/19/13719

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13 September 2022

https://doi.org/10.1016/s0021-9258(18)42273-9

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6 December 2023

https://api.elsevier.com/content/article/PII:S0021925818422739?httpAccept=text/xml

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10.1016/S0021-9258(18)42273-9

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6 December 2023

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6 December 2023

Journal of Biological Chemistry

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18 September 2019

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18 September 2019

19

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18 September 2019

13719-13727

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1320027%20AND%20SRC:MED&resulttype=core&format=json

18 September 2019

After insulin binds

1

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10.1016/S0021-9258(18)42273-9

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6 December 2023

Molecular basis of insulin receptor function

2

1 reference

10.1016/S0021-9258(18)42273-9

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6 December 2023

The insulin receptor: structure and function

3

1 reference

10.1016/S0021-9258(18)42273-9

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6 December 2023

The insulin receptor. A multifunctional protein

4

1 reference

10.1016/S0021-9258(18)42273-9

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6 December 2023

Replacement of lysine residue 1030 in the putative ATP-binding region of the insulin receptor abolishes insulin- and antibody-stimulated glucose uptake and receptor kinase activity

5

1 reference

10.1016/S0021-9258(18)42273-9

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6 December 2023

Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

11

1 reference

10.1016/S0021-9258(18)42273-9

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6 December 2023

Insulin binding to its receptor induces a conformational change in the receptor C-terminus

14

1 reference

10.1016/S0021-9258(18)42273-9

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6 December 2023

Analysis of insulin-receptor phosphorylation sites in intact cells by two-dimensional phosphopeptide mapping

17

1 reference

10.1016/S0021-9258(18)42273-9

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6 December 2023

Replacement of insulin receptor tyrosine residues 1162 and 1163 does not alter the mitogenic effect of the hormone

22

1 reference

10.1016/S0021-9258(18)42273-9

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6 December 2023

The insulin receptor with phenylalanine replacing tyrosine-1146 provides evidence for separate signals regulating cellular metabolism and growth

23

1 reference

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6 December 2023

Transmembrane signalling by insulin via an insulin receptor mutated at tyrosines 1158, 1162, and 1163.

25

1 reference

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6 December 2023

Autoantibodies to insulin receptors

27

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10.1016/S0021-9258(18)42273-9

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6 December 2023

Insulin-like and insulin-inhibitory effects of monoclonal antibodies for different epitopes on the human insulin receptor

28

1 reference

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6 December 2023

Monoclonal antibodies to the human insulin receptor mimic a spectrum of biological effects in transfected 3T3/HIR fibroblasts without activating receptor kinase

29

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6 December 2023

Monoclonal antibodies to the insulin receptor mimic metabolic effects of insulin but do not stimulate receptor autophosphorylation in transfected NIH 3T3 fibroblasts

33

1 reference

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6 December 2023

Receptor cross-linking restores an insulin metabolic effect altered by mutation on tyrosine 1162 and tyrosine 1163

34

1 reference

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Monoclonal antibodies reacting with multiple epitopes on the human insulin receptor

35

1 reference

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6 December 2023

Insulin receptors internalize by a rapid, saturable pathway requiring receptor autophosphorylation and an intact juxtamembrane region

38

1 reference

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The insulin receptor as a transmitter of a mitogenic signal in Chinese hamster ovary CHO-K1 cells

39

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Tyrosine phosphorylation of the insulin receptor is not required for receptor internalization: studies in 2,4-dinitrophenol-treated cells

42

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Mutation of tyrosine residues 1162 and 1163 of the insulin receptor affects hormone and receptor internalization

43

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Analysis of insulin receptor phosphorylation sites in intact rat liver cells by two-dimensional phosphopeptide mapping. Predominance of the tris-phosphorylated form of the kinase domain after stimulation by insulin.

44

1 reference

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6 December 2023

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

45

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6 December 2023

Assessment of thein SituTyrosine Kinase Activity of Mutant Insulin Receptors Lacking Tyrosine Autophosphorylation Sites 1162 and 1163

47

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10.1016/S0021-9258(18)42273-9

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Anti-(insulin receptor) monoclonal antibody-stimulated tyrosine phosphorylation in cells transfected with human insulin receptor cDNA

50

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Receptors for insulin and insulin-like growth factor-I can form hybrid dimers. Characterisation of hybrid receptors in transfected cells

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Transdominant inhibition of tyrosine kinase activity in mutant insulin/insulin-like growth factor I hybrid receptors

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The human insulin receptor cDNA: the structural basis for hormone-activated transmembrane signalling

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Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

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Different ligand affinities of the two human insulin receptor splice variants are reflected in parallel changes in sensitivity for insulin action

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PubMed publication ID

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1320027%20AND%20SRC:MED&resulttype=core&format=json

18 September 2019

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