(Q69061183)

English

Increased cytotoxicity of 1-(2-chloroethyl)-1-nitroso-3(4-methyl)-cyclohexylurea by pretreatment with O6-methylguanine in resistant but not in sensitive human melanoma cells

scientific article published on 01 January 1987

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scholarly article

1 reference

Europe PubMed Central

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29 September 2019

Increased cytotoxicity of 1-(2-chloroethyl)-1-nitroso-3(4-methyl)-cyclohexylurea by pretreatment with O6-methylguanine in resistant but not in sensitive human melanoma cells (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3597524%20AND%20SRC:MED&resulttype=core&format=json

29 September 2019

author name string

W Dempke

1

1 reference

Europe PubMed Central

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29 September 2019

P Nehls

2

1 reference

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29 September 2019

U Wandl

3

1 reference

Europe PubMed Central

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29 September 2019

D Soll

4

1 reference

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29 September 2019

C G Schmidt

5

1 reference

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29 September 2019

R Osieka

6

1 reference

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29 September 2019

publication date

1 January 1987

1 reference

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29 September 2019

Journal of Cancer Research and Clinical Oncology

1 reference

Europe PubMed Central

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29 September 2019

113

1 reference

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29 September 2019

4

1 reference

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29 September 2019

387-391

1 reference

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29 September 2019

https://scigraph.springernature.com/pub.10.1007/bf00397725

0 references

Sensitivity of human cell strains having different abilities to repair O6-methylguanine in DNA to inactivation by alkylating agents including chloroethylnitrosoureas

1 reference

https://pubmed.ncbi.nlm.nih.gov/3597524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactivation of purified human O6-alkylguanine-DNA alkyltransferase by alkylating agents or alkylated DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/3597524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of O6-alkyldeoxyguanosines and their effect on removal of O6-methylguanine from rat liver DNA

1 reference

https://pubmed.ncbi.nlm.nih.gov/3597524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

O6-Alkylguanine-DNA alkyltransferase activity correlates with the therapeutic response of human rhabdomyosarcoma xenografts to 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea

1 reference

https://pubmed.ncbi.nlm.nih.gov/3597524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Prevention of 1-(3-deoxycytidyl),2-(1-deoxyguanosinyl)ethane cross-link formation in DNA by rat liver O6-alkylguanine-DNA alkyltransferase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3597524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A chemical basis for the antitumor activity of chloroethylnitrosoureas

1 reference

https://pubmed.ncbi.nlm.nih.gov/3597524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Possible depletion of a DNA repair enzyme in human lymphoma cells by subversive repair

1 reference

https://pubmed.ncbi.nlm.nih.gov/3597524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Contributions of nitrosoureas to cancer treatment

1 reference

https://pubmed.ncbi.nlm.nih.gov/3597524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Pretreatment of normal human fibroblasts and human colon carcinoma cells with MNNG allows chloroethylnitrosourea to produce DNA interstrand crosslinks not observed in cells treated with chloroethylnitrosourea alone.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3597524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

DNA Repair Enzymes

1 reference

https://pubmed.ncbi.nlm.nih.gov/3597524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

O6-Methylguanine-DNA methyltransferase of human lymphoid cells: structural and kinetic properties and absence in repair-deficient cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/3597524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reduction of O6-alkylguanine-DNA alkyltransferase activity in HeLa cells treated with O6-alkylguanines.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3597524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

More than additive toxicity of the combination of 1-methyl-1-nitrosourea plus 1,3-bis(2-chloroethyl)-1-nitrosourea in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/3597524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chemical mutagenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/3597524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of the cross-link 1-[N3-deoxycytidyl),2-[N1-deoxyguanosinyl]ethane in DNA treated with N,N'-bis(2-chloroethyl)-N-nitrosourea.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3597524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on drug resistance in a human melanoma xenograft system

1 reference

https://pubmed.ncbi.nlm.nih.gov/3597524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Repair of O6-propylguanine and O6-butylguanine in DNA by O6-alkylguanine-DNA alkyltransferases from rat liver and E. coli

1 reference

https://pubmed.ncbi.nlm.nih.gov/3597524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of megakaryocytes, macrophages, and eosinophils in colonies of human bone marrow containing neurtophilic granulocytes and erythroblasts

1 reference

https://pubmed.ncbi.nlm.nih.gov/3597524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inactivation of O6-methylguanine-DNA methyltransferase and sensitization of human tumor cells to killing by chloroethylnitrosourea by O6-methylguanine as a free base.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3597524

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF00397725

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3597524%20AND%20SRC:MED&resulttype=core&format=json

29 September 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3597524%20AND%20SRC:MED&resulttype=core&format=json

29 September 2019

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