Wikidata

(Q6917578)

English

SMAD family member 7

mammalian protein found in Homo sapiens

  • mothers against decapentaplegic homolog 7
  • mothers against DPP homolog 8
  • Mothers against decapentaplegic, drosophila, homolog of, 7
  • hSMAD7
  • SMAD, mothers against DPP homolog 7
  • MAD (mothers against decapentaplegic, Drosophila) homolog 7
  • MAD homolog 8
  • SMAD 7
  • Mothers against decapentaplegic homolog 8
  • SMAD7
  • Smad7 Protein
In more languages

Statements

instance of
I-SMAD
0 references
molecular function
protein binding
determination method
IPI
13 references
retrieved
8 April 2019
stated in
USP15 stabilizes TGF-β receptor I and promotes oncogenesis through the activation of TGF-β signaling in glioblastoma
GOA
curator
UniProt
UniProt protein ID
O15105
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15105
determination method
IPI
retrieved
8 April 2019
stated in
Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15105
determination method
IPI
retrieved
8 April 2019
stated in
Jab1/CSN5, a component of the COP9 signalosome, regulates transforming growth factor beta signaling by binding to Smad7 and promoting its degradation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15105
determination method
IPI
retrieved
8 April 2019
stated in
Structural basis for the versatile interactions of Smad7 with regulator WW domains in TGF-β Pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15105
determination method
IPI
retrieved
8 April 2019
stated in
Functional proteomics mapping of a human signaling pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15105
determination method
IPI
retrieved
8 April 2019
stated in
Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15105
determination method
IPI
retrieved
8 April 2019
stated in
Ligand binding to WW tandem domains of YAP2 transcriptional regulator is under negative cooperativity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15105
determination method
IPI
retrieved
8 April 2019
stated in
FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15105
determination method
IPI
retrieved
8 April 2019
stated in
Coupling of tandem Smad ubiquitination regulatory factor (Smurf) WW domains modulates target specificity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15105
determination method
IPI
retrieved
8 April 2019
stated in
Smad7 is inactivated through a direct physical interaction with the LIM protein Hic-5/ARA55
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15105
determination method
IPI
retrieved
8 April 2019
stated in
FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15105
determination method
IPI
retrieved
8 April 2019
stated in
Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15105
determination method
IPI
retrieved
8 April 2019
stated in
Smad7 stabilizes beta-catenin binding to E-cadherin complex and promotes cell-cell adhesion
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:O15105
determination method
IPI
cell component
biological process
Gene Atlas image
PBB GE SMAD7 204790 at fs.png
732 × 530; 11 KB
0 references

Identifiers

MeSH descriptor ID
D051906
subject named as
Smad7 Protein
0 references
 
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