Wikidata

(Q6951383)

English

MYCN proto-oncogene, bHLH transcription factor

mammalian protein found in Homo sapiens

  • MYCN
  • N-myc proto-oncogene protein
  • neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene
  • pp65/67
  • oncogene NMYC
  • v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog
  • class E basic helix-loop-helix protein 37
  • bHLHe37
  • neuroblastoma MYC oncogene
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No label defined

No description defined

Statements

molecular function
protein binding
determination method or standard
IPI
13 references
retrieved
9 May 2019
stated in
Structural basis of N-Myc binding by Aurora-A and its destabilization by kinase inhibitors
GOA
curator
UniProt
UniProt protein ID
P04198
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198
determination method or standard
IPI
retrieved
9 May 2019
stated in
Functional interaction of Yaf2 with the central region of MycN
GOA
curator
UniProt
UniProt protein ID
P04198
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198
determination method or standard
IPI
retrieved
9 May 2019
stated in
Nmi protein interacts with regions that differ between MycN and Myc and is localized in the cytoplasm of neuroblastoma cells in contrast to nuclear MycN
GOA
curator
UniProt
UniProt protein ID
P04198
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198
determination method or standard
IPI
retrieved
9 May 2019
stated in
Drugging MYCN through an allosteric transition in Aurora kinase A
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198
determination method or standard
IPI
retrieved
9 May 2019
stated in
N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198
determination method or standard
IPI
retrieved
9 May 2019
stated in
Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198
determination method or standard
IPI
retrieved
9 May 2019
stated in
Activation of tissue transglutaminase transcription by histone deacetylase inhibition as a therapeutic approach for Myc oncogenesis.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198
determination method or standard
IPI
retrieved
9 May 2019
stated in
Nmi protein interacts with regions that differ between MycN and Myc and is localized in the cytoplasm of neuroblastoma cells in contrast to nuclear MycN
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198
determination method or standard
IPI
retrieved
9 May 2019
stated in
SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198
determination method or standard
IPI
retrieved
9 May 2019
stated in
Small molecule inhibitors of aurora-a induce proteasomal degradation of N-myc in childhood neuroblastoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198
determination method or standard
IPI
retrieved
9 May 2019
stated in
p14ARF interacts with N-Myc and inhibits its transcriptional activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198
determination method or standard
IPI
retrieved
9 May 2019
stated in
Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198
determination method or standard
IPI
retrieved
9 May 2019
stated in
The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198
determination method or standard
IPI
cell component
nucleus
determination method or standard
IBA
IDA
IEA
TAS
6 references
retrieved
9 May 2019
stated in
Human proto-oncogene N-myc encodes nuclear proteins that bind DNA
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198
determination method or standard
TAS
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P04198
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198
determination method or standard
IEA
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198
determination method or standard
IEA
retrieved
9 May 2019
stated in
Nmi protein interacts with regions that differ between MycN and Myc and is localized in the cytoplasm of neuroblastoma cells in contrast to nuclear MycN
GOA
curator
UniProt
UniProt protein ID
P04198
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198
determination method or standard
IDA
retrieved
9 May 2019
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198
determination method or standard
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04198
determination method or standard
IBA
biological process
Gene Atlas image
PBB GE MYCN 209757 s at fs.png
732 × 530; 12 KB
0 references

Identifiers

MeSH descriptor ID
D000071447
subject named as
N-Myc Proto-Oncogene Protein
0 references
 
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