(Q70265079)

English

Effects of perfusate flow rate on measured blood volume, disse space, intracellular water space, and drug extraction in the perfused rat liver preparation: characterization by the multiple indicator dilution technique

scientific article published on 01 December 1988

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3074996%20AND%20SRC:MED&resulttype=core&format=json

10 October 2019

Effects of perfusate flow rate on measured blood volume, disse space, intracellular water space, and drug extraction in the perfused rat liver preparation: characterization by the multiple indicator dilution technique (English)

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Europe PubMed Central

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10 October 2019

author name string

K S Pang

1

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10 October 2019

W F Lee

2

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10 October 2019

W F Cherry

3

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10 October 2019

V Yuen

4

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10 October 2019

J Accaputo

5

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10 October 2019

S Fayz

6

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10 October 2019

A J Schwab

7

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10 October 2019

C A Goresky

8

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10 October 2019

publication date

1 December 1988

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10 October 2019

Journal of Pharmacokinetics and Pharmacodynamics

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10 October 2019

16

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10 October 2019

6

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10 October 2019

595-632

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10 October 2019

https://scigraph.springernature.com/pub.10.1007/bf01062014

0 references

Models of hepatic drug clearance: discrimination between the ‘well stirred’ and ‘parallel-tube’ models

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metabolism of acetaminophen and phenacetin by isolated rat hepatocytes. A system in which the spatial organization inherent in the liver is disrupted

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ethanol oxidation by isolated hepatocytes from fed and starved rats and from rats exposed to ethanol, phenobarbitone or 3-amino-trizazole. No evidence for a physiological role of a microsomal ethanol oxidation system.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lack of liver vascular response to carotid occlusion in mildly acidotic dogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Albumin influences sulfobromophthalein transport by hepatocytes of each acinar zone.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterogeneity within observed regions: physiologic basis and effects on estimation of rates of biodynamic processes

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of saturating metabolic uptake on space profiles and tracer kinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Liver circulation and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of hepatic blood flow on the hepatic removal rate of oxyphenbutazone in the dog

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of capillary heterogeneity on rates of steady uptake of substances by the intact liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vasomotor activity in the isolated perfused rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Combined hepatic arterial-portal venous and hepatic arterial-hepatic venous perfusions to probe the abundance of drug metabolizing activities: perihepatic venous O-deethylation activity for phenacetin and periportal sulfation activity for acetaminop

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The multiple-indicator dilution technique for characterization of normal and retrograde flow in once-through rat liver perfusions

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mixed function oxidation in perfused rat liver. The effect of aminopyrine on oxygen uptake.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Reflex sympathetic effects on liver vascular space and liver perfusion in dogs

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of sinusoidal perfusion on galactose elimination kinetics in perfused rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic clearance of drugs. II. Experimental evidence for acceptance of the “well-stirred” model over the “parallel tube” model using lidocaine in the perfused rat liverin situ preparation

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

On the uptake of materials by the intact liver. The transport and net removal of galactose

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transport of fluorescent compounds into hepatocytes and the resultant zonal labeling of the hepatic acinus in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Current models of hepatic pharmacokinetics: flow effects on kinetic constants of ethanol elimination in perfused rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic elimination of flowing substrates: the distributed model

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Blood flow and norepinephrine effects on liver vascular and extravascular volumes

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic drug clearance model: comparison among the distributed, parallel-tube and well-stirred models

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of metabolite formation and elimination in the perfused rat liver preparation: differences between the elimination of preformed acetaminophen and acetaminophen formed from phenacetin

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ethanol elimination kinetics in human liver and pig liver in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Increased clearance of antipyrine and d-propranolol after phenobarbital treatment in the monkey. Relative contributions of enzyme induction and increased hepatic blood flow

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Uptake of monohydric alcohols by liver: demonstration of a shared enzymic space

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Conjugation kinetics of acetaminophen by the perfused rat liver preparation

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heterogeneous intrahepatic distribution of blood flow in humans

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An immunohistochemical study on the localization and distributions of phenobarbital- and 3-methylcholanthrene-inducible cytochromes P-450 within the livers of untreated rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Gas-liquid chromatographic determination of ethanol and acetaldehyde in tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Retrograde perfusion to probe the heterogeneous distribution of hepatic drug metabolizing enzymes in rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Flow dependence of propranolol elimination in perfused rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Maximal substrate transport in capillary networks

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A linear method for determining liver sinusoidal and extravascular volumes

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clearance approaches in pharmacology.

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Clearance concepts in pharmacokinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of intercellular distribution of drug-metabolizing enzymes on the kinetics of stable metabolite formation and elimination by liver: first-pass effects

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

O2 uptake in periportal and pericentral regions of liver lobule in perfused liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Norepinephrine: a potential modulator of the hepatic transport of taurocholate. a study in the isolated perfused rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of meperidine N-demethylation in the perfused rat liver preparation

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of route of administration and blood flow on hepatic drug elimination

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Circulatory pathways in the rat liver as revealed by P32 chromic phosphate colloid uptake in the isolated perfused liver preparation

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rates of alcohol dehydrogenase-dependent ethanol metabolism in periportal and pericentral regions of the perfused rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ethanol metabolism: oxidative and peroxidative mechanisms

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The influence of oxygen tension on theophylline clearance in the rat isolated perfused liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The hepatic sinusoid is not well-stirred: estimation of the degree of axial mixing by analysis of lobular concentration gradients formed during uptake of thyroxine by the perfused rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Hemodynamics of the vascular tree of the isolated rat liver preparation

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Saturation kinetics in hepatic drug removal: a statistical approach to functional heterogeneity

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Importance of flow and haematocrit for metabolic function of perfused rat liver

1 reference

https://pubmed.ncbi.nlm.nih.gov/3074996

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF01062014

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3074996%20AND%20SRC:MED&resulttype=core&format=json

10 October 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3074996%20AND%20SRC:MED&resulttype=core&format=json

10 October 2019

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