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English
TCR activation of ZAP70 is impaired in CD4+CD8+ thymocytes as a consequence of intrathymic interactions that diminish available p56lck
scientific article published on 01 May 1996
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Europe PubMed Central
PubMed publication ID
8630734
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8630734%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 October 2019
title
TCR activation of ZAP70 is impaired in CD4+CD8+ thymocytes as a consequence of intrathymic interactions that diminish available p56lck
(English)
1 reference
stated in
Europe PubMed Central
PubMed publication ID
8630734
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8630734%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 October 2019
main subject
thymocyte
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author
David L. Wiest
series ordinal
1
1 reference
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Europe PubMed Central
PubMed publication ID
8630734
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8630734%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 October 2019
author name string
J M Ashe
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2
1 reference
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Europe PubMed Central
PubMed publication ID
8630734
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8630734%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 October 2019
R Abe
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3
1 reference
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Europe PubMed Central
PubMed publication ID
8630734
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8630734%20AND%20SRC:MED&resulttype=core&format=json
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16 October 2019
J B Bolen
series ordinal
4
1 reference
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Europe PubMed Central
PubMed publication ID
8630734
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8630734%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 October 2019
A Singer
series ordinal
5
1 reference
stated in
Europe PubMed Central
PubMed publication ID
8630734
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8630734%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 October 2019
publication date
1 May 1996
1 reference
stated in
Europe PubMed Central
PubMed publication ID
8630734
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8630734%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 October 2019
published in
Immunity
1 reference
stated in
Europe PubMed Central
PubMed publication ID
8630734
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8630734%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 October 2019
volume
4
1 reference
stated in
Europe PubMed Central
PubMed publication ID
8630734
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8630734%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 October 2019
issue
5
1 reference
stated in
Europe PubMed Central
PubMed publication ID
8630734
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8630734%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 October 2019
page(s)
495-504
1 reference
stated in
Europe PubMed Central
PubMed publication ID
8630734
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8630734%20AND%20SRC:MED&resulttype=core&format=json
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16 October 2019
cites work
Defective T cell receptor signaling in mice lacking the thymic isoform of p59fyn
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The role of protein tyrosine kinases and protein tyrosine phosphatases in T cell antigen receptor signal transduction
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Another view of the selective model of thymocyte selection.
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Mice lacking MHC class II molecules
1 reference
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7 January 2021
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Identification of a murine monoclonal antibody specific for an allotypic determinant on mouse CD3
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7 January 2021
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Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes.
1 reference
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7 January 2021
based on heuristic
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Characterization of the Murine Antigenic Determinant, Designated L3T4a, Recognized by Monoclonal Antibody GK 1.5: Expression of L3T4a by Functional T Cell Clones Appears to Correlate Primarily with Class II MHC Antigen-Reactivity
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
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7 January 2021
based on heuristic
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Human severe combined immunodeficiency due to a defect in ZAP-70, a T cell tyrosine kinase
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Both immature and mature T cells mobilize Ca2+ in response to antigen receptor crosslinking
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
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7 January 2021
based on heuristic
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Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice.
1 reference
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https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
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7 January 2021
based on heuristic
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Expression and function of the CD3-antigen receptor on murine CD4+8+ thymocytes
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Subcellular localization of T-cell receptor complexes containing tyrosine-phosphorylated zeta proteins in immature CD4+CD8+ thymocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
T cell activation by clustered tyrosine kinases
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Xenogeneic Monoclonal Antibodies to Mouse Lymphoid Differentiation Antigens*
1 reference
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Crossref
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7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of a monoclonal antibody specific for a murine T3 polypeptide
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
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7 January 2021
based on heuristic
inferred from DOI database lookup
Cross-linking of T-cell surface molecules CD4 and CD8 stimulates phosphorylation of the lck tyrosine protein kinase at the autophosphorylation site
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists
1 reference
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Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Engagement of the CD4 molecule influences cell surface expression of the T-cell receptor on thymocytes.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Profound block in thymocyte development in mice lacking p56lck
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Intrathymic signalling in immature CD4+ CD8+ thymocytes results in tyrosine phosphorylation of the T-cell receptor zeta chain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Inhibition of T cell receptor expression and function in immature CD4+CD8+ cells by CD4
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Essential role for ZAP-70 in both positive and negative selection of thymocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Binding of ZAP-70 to phosphorylated T-cell receptor zeta and eta enhances its autophosphorylation and generates specific binding sites for SH2 domain-containing proteins
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activation of human peripheral blood T lymphocytes by pharmacological induction of protein-tyrosine phosphorylation
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Normal development and function of CD8+ cells but markedly decreased helper cell activity in mice lacking CD4
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Selective events in T cell development
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identification of the components of the murine T cell antigen receptor complex
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Association of the fyn protein-tyrosine kinase with the T-cell antigen receptor
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The lck tyrosine protein kinase interacts with the cytoplasmic tail of the CD4 glycoprotein through its unique amino-terminal domain
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Partial T cell signaling: altered phospho-zeta and lack of zap70 recruitment in APL-induced T cell anergy
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
GPI-Anchored Cell-Surface Molecules Complexed to Protein Tyrosine Kinases
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
pp59fyn mutant mice display differential signaling in thymocytes and peripheral T cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Asymmetric signaling requirements for thymocyte commitment to the CD4+ versus CD8+ T cell lineages: a new perspective on thymic commitment and selection.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Distribution of H-2 microenvironments in the mouse thymus. Immunoelectron microscopic identification of I-A and H-2K bearing cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
ZAP-70 is constitutively associated with tyrosine-phosphorylated TCR ζ in murine thymocytes and lymph node T cells
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
F2(Pmp)2-TAM zeta 3, a novel competitive inhibitor of the binding of ZAP-70 to the T cell antigen receptor, blocks early T cell signaling
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70.
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of Zap-70 by Src family tyrosine protein kinases in an antigen-specific T-cell line
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Developmentally regulated expression of CD3 components independent of clonotypic T cell antigen receptor complexes on immature thymocytes
1 reference
stated in
Crossref
reference URL
https://api.crossref.org/works/10.1016%2FS1074-7613%2800%2980415-X
retrieved
7 January 2021
based on heuristic
inferred from DOI database lookup
Identifiers
DOI
10.1016/S1074-7613(00)80415-X
1 reference
stated in
Europe PubMed Central
PubMed publication ID
8630734
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8630734%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 October 2019
PubMed publication ID
8630734
1 reference
stated in
Europe PubMed Central
PubMed publication ID
8630734
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8630734%20AND%20SRC:MED&resulttype=core&format=json
retrieved
16 October 2019
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