(Q71377731)

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Mutation of two conserved arginine residues in the glucose transporter GLUT4 supresses transport activity, but not glucose-inhibitable binding of inhibitory ligands

scientific article published on 01 December 1995

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18 October 2019

Mutation of two conserved arginine residues in the glucose transporter GLUT4 supresses transport activity, but not glucose-inhibitable binding of inhibitory ligands (English)

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Europe PubMed Central

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18 October 2019

Annette Schürmann

2

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18 October 2019

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S Wandel

1

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18 October 2019

W Becker

3

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18 October 2019

S A Summers

4

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18 October 2019

M F Shanahan

5

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18 October 2019

H G Joost

6

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18 October 2019

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1 December 1995

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18 October 2019

Naunyn-Schmiedeberg's Archives of Pharmacology

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Europe PubMed Central

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18 October 2019

353

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18 October 2019

1

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18 October 2019

36-41

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18 October 2019

Functional consequences of proline mutations in the putative transmembrane segments 6 and 10 of the glucose transporter GLUT1.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identification of a novel gene encoding an insulin-responsive glucose transporter protein

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Subcellular distribution and activity of glucose transporter isoforms GLUT1 and GLUT4 transiently expressed in COS-7 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Derivatization of the human erythrocyte glucose transporter using a novel forskolin photoaffinity label

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substitution of conserved tyrosine residues in helix 4 (Y143) and 7 (Y293) affects the activity, but not IAPS-forskolin binding, of the glucose transporter GLUT4.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rapid and efficient site-specific mutagenesis without phenotypic selection

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential sensitivity to guanine nucleotides of basal and insulin-stimulated glucose transporter activity reconstituted from adipocyte membrane fractions

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substitution of tyrosine 293 of GLUT1 locks the transporter into an outward facing conformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Control of topology and mode of assembly of a polytopic membrane protein by positively charged residues

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Development of the hormone-sensitive glucose transport activity in differentiating 3T3-L1 murine fibroblasts. Role of the two transporter species and their subcellular localization

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Localization of the binding domain of the inhibitory ligand forskolin in the glucose transporter GLUT-4 by photolabeling, proteolytic cleavage and a site-specific antiserum

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Site-directed mutagenesis of GLUT1 in helix 7 residue 282 results in perturbation of exofacial ligand binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Kinetics of the purified glucose transporter. Direct measurement of the rates of interconversion of transporter conformers

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An improved method of reconstitution of adipocyte glucose transport activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Substitution of leucine for tryptophan 412 does not abolish cytochalasin B labeling but markedly decreases the intrinsic activity of GLUT1 glucose transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Forskolin inhibits insulin-stimulated glucose transport in rat adipose cells by a direct interaction with the glucose transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure-function relationship of glucose transporters catalyzing facilitated diffusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A graphic method for the determination and presentation of binding parameters in a complex system

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Photolabelling of the hexose transporter at external and internal sites: fragmentation patterns and evidence for a conformational change

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Molecular biology of mammalian glucose transporters

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Metal-tetracycline/H+ antiporter of Escherichia coli encoded by transposon Tn10. The role of a conserved sequence motif, GXXXXRXGRR, in a putative cytoplasmic loop between helices 2 and 3

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Glucose transport activity and photolabelling with 3-[125I]iodo-4-azidophenethylamido-7-O-succinyldeacetyl (IAPS)-forskolin of two mutants at tryptophan-388 and -412 of the glucose transporter GLUT1: dissociation of the binding domains of forskolin

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Amino acid substitutions at tryptophan 388 and tryptophan 412 of the HepG2 (Glut1) glucose transporter inhibit transport activity and targeting to the plasma membrane in Xenopus oocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The glucose transport activity of GLUT1 is markedly decreased by substitution of a single amino acid with a different charge at residue 415

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differentiation of erythrocyte-(GLUT1), liver-(GLUT2), and adipocyte-type (GLUT4) glucose transporters by binding of the inhibitory ligands cytochalasin B, forskolin, dipyridamole, and isobutylmethylxanthine

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The differential role of Cys-421 and Cys-429 of the Glut1 glucose transporter in transport inhibition by p-chloromercuribenzenesulfonic acid (pCMBS) or cytochalasin B (CB)

1 reference

https://pubmed.ncbi.nlm.nih.gov/8750914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF00168913

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8750914%20AND%20SRC:MED&resulttype=core&format=json

18 October 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8750914%20AND%20SRC:MED&resulttype=core&format=json

18 October 2019

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