(Q71574037)

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Binding of fibrin monomer and heparin to thrombin in a ternary complex alters the environment of the thrombin catalytic site, reduces affinity for hirudin, and inhibits cleavage of fibrinogen

scientific article published on 01 October 1996

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scholarly article

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19 October 2019

Binding of fibrin monomer and heparin to thrombin in a ternary complex alters the environment of the thrombin catalytic site, reduces affinity for hirudin, and inhibits cleavage of fibrinogen (English)

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8824251%20AND%20SRC:MED&resulttype=core&format=json

19 October 2019

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P J Hogg

1

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19 October 2019

C M Jackson

2

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19 October 2019

J K Labanowski

3

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19 October 2019

P E Bock

4

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19 October 2019

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1 October 1996

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19 October 2019

Journal of Biological Chemistry

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19 October 2019

271

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19 October 2019

42

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19 October 2019

26088-26095

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19 October 2019

The clot thickens: clues provided by thrombin structure.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.42.26088

21 January 2018

The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.42.26088

21 January 2018

A player of many parts: the spotlight falls on thrombin's structure.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.42.26088

21 January 2018

Thrombin inhibitors A new generation of antithrombotics

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.42.26088

21 January 2018

Anion-binding exosite of human alpha-thrombin and fibrin(ogen) recognition

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.42.26088

21 January 2018

Characterization of the kinetic pathway for fibrin promotion of alpha-thrombin-catalyzed activation of plasma factor XIII

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.42.26088

21 January 2018

Clotting of bovine fibrinogen. Kinetic analysis of the release of fibrinopeptides by thrombin and of the calcium uptake upon clotting at high fibrinogen concentrations.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.42.26088

21 January 2018

Regulation of formation of factor XIIIa by its fibrin substrates

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.42.26088

21 January 2018

The structure of a complex of recombinant hirudin and human alpha-thrombin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.42.26088

21 January 2018

Refined structure of the hirudin-thrombin complex

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.42.26088

21 January 2018

Molecular mapping of the heparin-binding exosite of thrombin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.42.26088

21 January 2018

Fibrin monomer protects thrombin from inactivation by heparin-antithrombin III: implications for heparin efficacy.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.42.26088

21 January 2018

p-Nitrophenyl-p'-guanidinobenzoate HCl: a new active site titrant for trypsin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.42.26088

21 January 2018

Studies on a highly active anticoagulant fraction of high molecular weight isolated from porcine sodium heparin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.42.26088

21 January 2018

Reaction of thrombins with human antithrombin III. I. Enzyme activity losses unrelated to the inhibitory reaction and their prevention

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.42.26088

21 January 2018

Studies on synthetic peptides that bind to fibrinogen and prevent fibrin polymerization. Structural requirements, number of binding sites, and species differences

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.42.26088

21 January 2018

The analysis of progress curves for enzyme-catalysed reactions by non-linear regression

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.42.26088

21 January 2018

Kinetics of the inhibition of thrombin by hirudin.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.42.26088

21 January 2018

Hirudin and hirudin-based peptides.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.42.26088

21 January 2018

Phenomenological analysis of the clotting curve

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.42.26088

21 January 2018

Effect of thrombomodulin on the kinetics of the interaction of thrombin with substrates and inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.42.26088

21 January 2018

The action of thrombin on peptide p-nitroanilide substrates. Substrate selectivity and examination of hydrolysis under different reaction conditions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.42.26088

21 January 2018

Use of site-directed mutagenesis to investigate the basis for the specificity of hirudin.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.42.26088

21 January 2018

Effect of heparin on the interaction between thrombin and hirudin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.42.26088

21 January 2018

alpha-Thrombin within fibrin clots: inactivation of thrombin by antithrombin-III

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.42.26088

21 January 2018

Clot-bound thrombin is protected from inhibition by heparin-antithrombin III but is susceptible to inactivation by antithrombin III-independent inhibitors

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.42.26088

21 January 2018

Activation of blood coagulation by plaque rupture: mechanisms and prevention

1 reference

https://api.crossref.org/works/10.1074%2FJBC.271.42.26088

21 January 2018

Identifiers

10.1074/JBC.271.42.26088

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8824251%20AND%20SRC:MED&resulttype=core&format=json

19 October 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8824251%20AND%20SRC:MED&resulttype=core&format=json

19 October 2019

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